No 2 (2013)

The paper deals with study of locating, content and composition of fatty oil in Siberian Dogwood’s fruits, pericarp and seed.

The results of a study on the use of pharmacoeconomic analysis to justify the rational choice of drug therapy and costs of the program activities for the prevention and treatment of diseases are presented. A comparative analysis of the cost of treatment of liposomal and the traditional forms of doxorubicin was conducted. Justified costs (in terms of drug provision) for realization of the program of prevention and treatment of diseases related to iodine deficiency in children in the Republic of Karachay-Cherkessia (KChR) for 2010—2015, based on the use of «default values» of expenses, received in the result of pharmacoeconomic analysis and prognosis of the disease.

The term “Transactional expenses” (TE) is a key concept in the modern institutional theory. These expenses are inevitable in the interaction of economic entities, and their value determines the effectiveness of this interaction. A classification of transaction expenses and based on their analysis the method of calculation of the optimum size of pharmacy networks is developed. The formulas and coefficients of TE information search, selection of TE, TE opportunism in antacid and antiulcer medications market were offered and calculated.

The data received from investigation of the relationship between the body weight and vital capacity of lungs of the Russian and foreign students of PFUR, who are studying in different courses. We identified their body height and weight, vital capacity of lungs and evaluated sickness rate. Analysis of the results shows that, there is a close relationship between the body weight and vital capacity of lungs in all tested individuals. However, for equal body weight, the Russian students have a greater vital capacity of lungs (average 500 ml) than the foreign ones. It revealed that during one-year adaptation to training in the University the body weight of the majority of students is increased. In Russian students with the increasing of body weight the vital capacity of lungs also elevates but in foreign students — decreases.

Objective: to study the efficacy of external cardiosynchronized muscular counterpulsation (CMC) in patients with different variants of acute heart failure. The study included the examination results of 62 patients with acute heart failure, which undergo two variants (two groups) of therapy: 1) only the standard drug therapy (diuretics, nitrates, etc .) and 2) in the case of its inefficacy over 12 hours, combination of the drug therapy with the CMC sessions over 7 days. The clinical assessment of the patients under examination characterized the group with the standard therapy as less severe. In 64% of the group 2 patients, a significant improvement in the form of improvement in the fluid balance indices was noted during the combined therapy.

Objective: to study vegetative balance at patients with brain tumors located in posterior and medium cranial fossas undergone neurosurgical operations. The analysis of cardiac rhythm variability, orthostatic test and Kerdo index were used as integrative markers of activity of vegetative nervous system. 68 patients from 17 to 71 years old were enrolled. The patients were divided into two groups depending on tumor localization. All 68 (100%) patients underwent orthostatic test using “Valenta” diagnostic system, the vegetative Kerdo index was calculated three times (before operation, after an introduction narcosis and after extubation). Daily variability of cardiac rhythm was investigated in 34 (50%) patients. The statistical analysis of results of the tests in two investigated groups had been carried out. Results: according to indicators of Kerdo index, before operation the activity of parasympathetic nervous systems dominated in patients with tumor localization both in posterior and medium cranial fossa. At calculations of Kerdo index after an introduction narcosis and after extubation the distinct tendency to a eutonia condition had been recorded. Analysis of active orthostatic test showed that in the most of the patients the minimum load (transition from a prone position in vertical standing) signs of sympatotonia prevailed. The depression of cardiac rhythm variability depended on tumor localization. More often essential decreasing of cardiac rhythm variability observed in patients with posterior fossa tumors.

Aim: to study the prognostic value of biomarkers (urine neutrophil gelatinase-associated lipocalin (uNGAL), urine interleukin-18 (uIL-18), serum cystatin C (sCysC), serum N-terminal prohormone of brain natriuretic peptide (sNT-proBNP) depending on the acute kidney injury (AKI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). 58 patients with NSTE-ACS were examined. Patients with NSTE-ACS and early AKI had higher sCysC, sNT-proBNP, uNGAL and uIL-18 levels than the patients without AKI. No relationship between biomarkers and in-hospital mortality was revealed in patients with cardiorenal syndrome (CRS). AKI — acute kidney injury NSTE-ACS — non-ST-elevation acute coronary syndrome CRS — cardiorenal syndrome NT-proBNP — N-terminal prohormone of Brain Natriuretic Peptide IL-18 — interleukin-18 NGAL — neutrophil gelatinase-associated lipocalin

HIV incidence is growing and becoming a threat to national security. The age structure is dominated by a person younger than 30 years (70.8%). There is an increase rate of HIV infection detection among pregnant women and an increasing number of children born by HIV-infected mothers. If the issues of specific prevention (preventive vaccinations), do not create any problems, the remaining questions of medical prevention are still unsolved to this day.