RUDN Journal of MedicineRUDN Journal of Medicine2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3249Research ArticleMammaglobin mRNA expression as early breast cancer markerBojenkoV Konstantinovichvbojenko@mail.ruSolodkyV Alekseevich-KharchenkoN VladimirovnaDepartment of oncology and radiologynkharchenko@mail.ruTrotsenkoI DmitrievichDepartment of oncology and radiologytrotsenkoivan@mail.ruTrofimovD Yur'evichdtrofimov@mail.ruKudinovaE Aleksandrovnaekudinova@mail.ruVaskevichE Fedorovnaevaskevich@mail.ruBurmenskayaO Vburmenskaya@mail.ruScientific Center of Roentgenoradiology of RAMSPeople’s Friendship University of Russia“DNA Technology”Research Center for Obstetrics, Gynecology and Perinatology150220132717707092016Copyright © 2013,2013Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.breast cancertumor progressionhMAM expressionmammaglobinuteroglobinрак молочной железыопухолевая прогрессияэкспрессия мРНКмаммаглобинутероглобин