Combined toxicity of Na                  2EDTA and D                  2O

T N Burdeinaya; Бурдейная Татьяна Николаевна; O Y Zrelov; Зрелов Олег Юрьевич; T V Maksimova; Максимова Татьяна Владимировна; M A Morozova; Морозова Мария Андреевна; G I Mtei; Мтеи Гасто Игнас; E V Uspenskaya; Успенская Елена Валерьевна; T V Pleteneva; Плетенева Татьяна Вадимовна; A V Syroeshkin; Сыроешкин Антон Владимирович

Combined toxicity of Na 2EDTA and D 2O

Authors: Burdeinaya TN¹, Zrelov OY², Maksimova TV², Morozova MA², Mtei GI², Uspenskaya EV², Pleteneva TV², Syroeshkin AV³
Affiliations:
1. ZAO “Legkaya voda”
2. Peoples’ Friendship University of Russia
3. Institute of Applied Geophysics
Issue: No 2 (2013)
Pages: 5-9
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3239

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Abstract

Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabilizers, fillers, etc.). Combined biological activity of stabilizer/antioxidant — disodium ethylenediaminetetraacetate (Na 2EDTA) — and water with different ratios of hydrogen isotopes (D / H) was studied on biological models of Spirotox. It was found that with the growth of deuterium/protium ratio in water the toxicity of Na 2EDTA increased.

Keywords

Spirotox, excipients, biopharmaceutical analysis, heavy water, Spirotox

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Combined toxicity of Na 2EDTA and D 2O

Full Text

Abstract

Keywords

About the authors

T N Burdeinaya

O Y Zrelov

T V Maksimova

M A Morozova

G I Mtei

E V Uspenskaya

T V Pleteneva

A V Syroeshkin

References

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