Mammaglobin mRNA expression as early breast cancer marker

V Konstantinovich Bojenko; Боженко Владимир Константинович; V Alekseevich Solodky; Солодкий Владимир Алексеевич; N Vladimirovna Kharchenko; Харченко Наталья Владимировна; I Dmitrievich Trotsenko; Троценко Иван Дмитриевич; D Yur'evich Trofimov; Трофимов Дмитрий Юрьевич; E Aleksandrovna Kudinova; Кудинова Елена Александровна; E Fedorovna Vaskevich; Васкевич Елена Федоровна; O V Burmenskaya; Бурменская Ольга Владимировна

Mammaglobin mRNA expression as early breast cancer marker

Authors: Bojenko VK.¹, Solodky VA.¹, Kharchenko NV.², Trotsenko ID.², Trofimov DY.³, Kudinova EA.¹, Vaskevich EF.¹, Burmenskaya OV⁴
Affiliations:
1. Scientific Center of Roentgenoradiology of RAMS
2. People’s Friendship University of Russia
3. “DNA Technology”
4. Research Center for Obstetrics, Gynecology and Perinatology
Issue: No 2 (2013)
Pages: 71-77
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3249

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Abstract

Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.

Keywords

breast cancer, tumor progression, hMAM expression, mammaglobin, uteroglobin

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Mammaglobin mRNA expression as early breast cancer marker

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About the authors

V Konstantinovich Bojenko

V Alekseevich Solodky

N Vladimirovna Kharchenko

I Dmitrievich Trotsenko

D Yur'evich Trofimov

E Aleksandrovna Kudinova

E Fedorovna Vaskevich

O V Burmenskaya

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