No 3 (2012)


Cytodenic characteristics of patients with brain tumors under treatment by verapamilum and ketamine in vitro

Fedoronchuk T.V., Syatkin S.P., Frolov V.A., Gridina N.Y., Boltina I.V.


There are results of analyzing of cytogenetic characteristics of patients with brain tumors under treatment by Verapamilum and Ketamine in vitro. Under the Verapamilum action it was shown sure decreasing of the chromosome aberrations frequencies just like decreasing of the aneuploid and polyploid cells quantity in patient's malignant tumors. It also was shown the substantial reduction in aneuploid cells number among tests of patients with malignant tumors under Ketamine exposure. Patients with benign or malignant tumors had the very lowest magnitudes of multyaberratic cells amount and of the extent of aberratic cell injury under the Verapamilum influence.
RUDN Journal of Medicine. 2012;(3):5-11
pages 5-11 views

Influence of thymic peptides preparation (t-activin) on anxiety level in rats

Novoseletskaya A.V., Inozemtsev A.N., Kiseleva N.M., Arion V.Y.


Influence of T-activin on anxiety level in rats in the Porsolt test and the tail suspension test has been studied. Positive effect of thymic polypeptides resulted in the reduction of immobility and in the increase of escape-related activity.
RUDN Journal of Medicine. 2012;(3):12-15
pages 12-15 views

Experimental model for the study of biologically determinated interactions in implant-bone contact

Shtansky D.V., Selezneva I.I., Babichenko I.I., Arkhipov A.V., Grigoryan A.S.


Aim: a) to develop the method for surface modification of polytetrafluoroethylene (PTFE) by applying a nanostructured metallic or ceramic coating, b) to study the possibility of using this obtained structures with different coatings as an experimental model for analysis of the fine interactions in the contact implant-tissue zone. The study demonstrates that the surface modification of PTFE by magnetron sputtering of nano-Ti and Ti-Ca-P-C-O-N leads to increased integration potential of materials. Data obtained indicate that the designed constructions can be successfully used as an experimental model for studying the interactions of implant - tissue interface elements of periimplant area.
RUDN Journal of Medicine. 2012;(3):16-21
pages 16-21 views

Effect of zinc nanoparticles on bacterial cells

Babushkina I.V., Chebotareva E.G., Elbudu М., Orlov S.B., Borodulina E.V., Borodulin V.B.


Antibacterial activity of nanoparticles of zinc on the clinical strains poliantibiotic resistent bacteria isolated from trauma- and orthopedic patients with purulent complications was studied. Bactericidal activity against strains of Staphylococcus aureus is shown.
RUDN Journal of Medicine. 2012;(3):22-25
pages 22-25 views

Biological factors of alcoholic liver disease progression

Ogurtsov P.P., Polikarpova T.S., Garmash I.V., Arisheva O.S., Guschin А.E., Tarasenko E.V., Myandina G.I.


Aim: to detect the genetic factors predisposing alcoholic liver lesion. The main candidate genes of high risk are isoforms of adh and aldh genes which are responsible for different level of alcohol metabolism and oxidation of ethanol and acetaldehyde. Our results demonstrated that allelic variant adh2-2 is observed more frequently in patients with alcoholic liver damage than in population (16% vs. 7%; p < 0,05). The polymorphism t174m of angiotensinogen gene AGT was investigated as one of the risk factor of alcoholic liver lesion. The allelic variant m of angiotensinogen gene AGT is more frequent (15.8%) in patients with alcoholic liver cirrhosis and alcohol abuse without cirrhosis (n = 98) than in population (6.7%, n = 52; p = 0.04). The highest frequency of allele m was in a group with alcoholic liver cirrhosis (17.3%; p = 0.058). Our data provides the evidence that polymorphism t174m of AGT gene does not influence the progression (clinical picture) of alcoholic liver cirrhosis, except the level of GGT, which is increased in patients with homozygous genotype tt.
RUDN Journal of Medicine. 2012;(3):26-30
pages 26-30 views

Immunological aspects of the development of hypertension and renal dysfunction in patients with chronic diseases of joints

Safronenko A.V., Harseeva G.G., Vystavkina E.A., Demidovа A.A., Demidov I.A.


The article is devoted to the study of the role of inflammation in the vascular lesions and visceral development in rheumatoid arthritis as autoimmunnom disease with a pronounced inflammatory component. Found that common markers of inflammation and proinflammatory cytokines in patients with elevated pathogenetic played a role in rheumatoid raising blood pressure and chronic kidney disease.
RUDN Journal of Medicine. 2012;(3):31-36
pages 31-36 views

Clinico-laboratory characteristics of early manifestation of tick-borne borreliosis (Lyme-disease)

Popova S.P., Bezborodov N.G., Polovinkina N.А., Golub V.P., Barisheva I.V., Voznesensky S.L.


50 patients with early manifestations of tick-borne borreliosis (Lyme-disease) with localized stage and mild and moderate clinical course were examined. It is established that early clinical and laboratory diagnostics and also timely prescription of antibiotics could to prevent the development of relapses and late complications.
RUDN Journal of Medicine. 2012;(3):37-42
pages 37-42 views

To the question of the prevention of severe pre-eclampsia in pregnant women with metabolic syndrome

Savel'eva I.V., Barinov S.V.


In article identified the main risk factors for pre-eclampsia in case of metabolic syndrome (MS) in pregnant women, shows the role of maternal antibodies to insulin in the forecast of development of pre-eclampsia and outlined the main ways of correction of the revealed violations. Presents algorithms for medical action aimed at the prevention of severe pre-eclampsia in patients with MS.
RUDN Journal of Medicine. 2012;(3):43-47
pages 43-47 views

The possible role of toxoplasmosis in the development of antiphospholipid antibodies in pregnancy-related complications

Bayati Ali Hattem Hussein -., Zainab Abdulhussain Hamed -.


The study studied the participation of toxoplasma gondii in the formation of antiphospholipid antibodies in pregnant women. The results showed that previous infection with toxoplasma gondii might lead to development antiphospholipid antibodies, which in turn might predispose to infertility, and abortion.
RUDN Journal of Medicine. 2012;(3):48-51
pages 48-51 views

Microbic spectrum of the vagina and myomatous knot at sick of the hysteromyoma

Rymashevsky A.Н., Nikitin E.S., Svirava E.G., Samsonov A.E., Naboka J.L.


22 patients of genital age with a hysteromyoma, not receiving antibacterial and a hormonetherapy in the preoperative period are surveyed. To the given group of patients operation with organ conservation is executed. To all patients bacteriological research of a vaginal microflora and a biological material taken of myomatous knots is conducted. At all women with a hysteromyoma were observed dysbiotic disturbances of a microflora of a vagina, in the form of concentration depression of lacto- bacterius and bifidobacteria and сoncentration augmentation of peptokokkus. At 9% of patients in myomatous knot growth of microorganisms is not taped. In 91% of cases myomatous knots are inseminated not clostridial anaerobic bacteria. Among the microorganisms allocated in myomatous knot the most part have made peptostreptokokkus. The conclusion. By results of the received data it is possible to assume that hysteromyoma presence is bound to dissemination not clostridial anaerobic bacteria.
RUDN Journal of Medicine. 2012;(3):52-57
pages 52-57 views

Evaluation of a knee-joint functional rehabilitation after total knee arthroplasty by standart and miniinvasive midvastus approaches

Prizov A.P., Lazko F.L., Kanaev A.S., Lomtatidze E.S.


The article presents comparative results of total knee arthroplasty of two groups of patients for gonarthrosis 3-4 stage perfomed by standart and minimally invasive midvastus approaches (30 knee joints in each group). Advantages and differences of these methods are discussed. Early and late postoperative outcomes are analyzed. Minimally invasive midvastus approach for total knee arthroplasty reduces duration of rehabilitation of the patients with gonarthrosis and improves its results, especially in early postoperative period.
RUDN Journal of Medicine. 2012;(3):58-65
pages 58-65 views

Registers of hip arthroplasty

Zagorodniy N.V., Lomtatidze E.S., Batygin G.G.


At the end of the XX and at the beginning of the XXI century the number of hip joint arthroplasty gained more than 1 million per year only for low friction hip prosthesis. To analyze all the structure of hip arthroplasty complications and to check revision arthroplasty the register of hip arthroplasty was introduced in Europe. In 1979 the Swedish scientist Peter Herberts initiated the first register in history of hip and knee arthroplasty. The arthroplasty register of scientific institute of travmatology and orthopedics of R.R. Vreden works as a local program of documentation and analysis. To create the national register of hip arthroplasty in Russia, financial, administrative and technological issues needs to get sufficient respect.
RUDN Journal of Medicine. 2012;(3):66-71
pages 66-71 views

Alternative treatment of over-erupted teeth

Kaplan M.Z., Romanоva O.V., Belorus S.A., Prokopyev V.V.


Teeth not exposed to chewing forces have a capacity for physiological tooth movement or tooth migration. The erupting tooth will erupt until it reaches occlusal contact and the final positioning of the teeth depends on the equilibrium between forces e. g. forces from the occlusion, tongue, lips and eruption. Therefore, overeruption is accommodation process. There are several methods to treat the disease: the intrusion by means of orthodontics appliances, selective alveolar corticotomy for intruding overerupted teeth, prosthetic crowns, tooth extraction. Surgical or orthodontic therapy may be inconvenient and they are not always as effective as desired. Available prosthetic options for restoration of occlusion include selective root canal treatment with invasive tooth reduction to reconstruct the occlusal plane and make enough places for porcelain fused to metal crowns. The alternative treatment was proposed by department of prosthodontics of Peoples' Friendship University of Russia. The only destroyed tooth is restored by ceramo-composite pinlay, thus making no changes in occlusion line. The indications for this method: orthodontic therapy is not effective, no blockage of jaw motions, no pathologic changes in temporomandibular joints.
RUDN Journal of Medicine. 2012;(3):72-75
pages 72-75 views

Аmino acids in serum and cerebrospinal fluid of children with Kanner syndrome

Gorina A.S., Kolesnichenko L.S., Mikhnovich V.I.


Levels of amino acids in serum and cerebrospinal fluid (CSF) were measured in children with Kanner syndrome. Serum aspartate, taurine and glutamine were increased whereas β-alanine, methionine and glycine decreased. In CSF, aspartate, glutamine, GABA, taurine and arginine increased and methionine decreased. Majority of changes in serum were parallel to the changes in CSF, but the changes in serum were more pronounced than in CSF. Together with the deficit in methionine, β-alanine and glycine, obtained data suggest intensification of transportation of glutamine, aspartate and taurine into CSF through blood-brain barrier. Changes in the concentrations of neurotransmitter amino acids (aspartate, taurine) may indicate an imbalance of excitatory and inhibitory mediators in brain.
RUDN Journal of Medicine. 2012;(3):76-82
pages 76-82 views

Characteristics of intracardiac hemodynamics in adolescents with constitutional-exogenous obesity before and after rehabilitation

Miroshnichenko O.M.


The diastolic function of the the left and right ventricles in adolescents with constitutional-exogenous obesity (CEO) and in healthy adolescents was studied. Diastolic dysfunction of the E/A ≤ 1,5 of the both ventricles was revealed: the left ventricle - 23.2% and the right ventricle - 20.9%.
RUDN Journal of Medicine. 2012;(3):83-85
pages 83-85 views

The study of acute toxicity and anabolic activity of oil of corn gern

Samoryadova A.B.


The work is dedicated to the pharmacological research of acute toxicity and anabolic action of oil of corn germs. It is established that oil of corn germs is referred to the virtually non-toxic preparations and has anabolic effects.
RUDN Journal of Medicine. 2012;(3):86-88
pages 86-88 views

Development of pollen morphology analysis techniques in propolis

Babaeva E.J., Danilina E.A., Vandishev V.V., Severova E.E.


The methodology of obtaining micropreparations of propolis was developed, pollen spectrum 13 samples from different regions was studied. Frequency of pollen types in the samples of propolis was analyzed.
RUDN Journal of Medicine. 2012;(3):89-94
pages 89-94 views

The importance of pharmacogenetic research for optimization of antihypertensive treatment

Shevchenko O.V., Bychkov E.N., Posnenkova O.M., Dovgalevsky P.Y., Bogoslovskaya S.I., Svistunov A.A.


As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.
RUDN Journal of Medicine. 2012;(3):95-100
pages 95-100 views

The role of computer diagnostic analysis in for improvement of medical knowledge

Sarookhanov B.A.


An algorithm of computer diagnostic rules clusterization is presented. It supports a possibility of rules interpretation as specialist's knowledge expansion tool.
RUDN Journal of Medicine. 2012;(3):101-105
pages 101-105 views

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RUDN Journal of Medicine. 2012;(3):106-111
pages 106-111 views

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