No 3 (2012)

There are results of analyzing of cytogenetic characteristics of patients with brain tumors under treatment by Verapamilum and Ketamine in vitro. Under the Verapamilum action it was shown sure decreasing of the chromosome aberrations frequencies just like decreasing of the aneuploid and polyploid cells quantity in patient's malignant tumors. It also was shown the substantial reduction in aneuploid cells number among tests of patients with malignant tumors under Ketamine exposure. Patients with benign or malignant tumors had the very lowest magnitudes of multyaberratic cells amount and of the extent of aberratic cell injury under the Verapamilum influence.

Aim: a) to develop the method for surface modification of polytetrafluoroethylene (PTFE) by applying a nanostructured metallic or ceramic coating, b) to study the possibility of using this obtained structures with different coatings as an experimental model for analysis of the fine interactions in the contact implant-tissue zone. The study demonstrates that the surface modification of PTFE by magnetron sputtering of nano-Ti and Ti-Ca-P-C-O-N leads to increased integration potential of materials. Data obtained indicate that the designed constructions can be successfully used as an experimental model for studying the interactions of implant - tissue interface elements of periimplant area.

Aim: to detect the genetic factors predisposing alcoholic liver lesion. The main candidate genes of high risk are isoforms of adh and aldh genes which are responsible for different level of alcohol metabolism and oxidation of ethanol and acetaldehyde. Our results demonstrated that allelic variant adh2-2 is observed more frequently in patients with alcoholic liver damage than in population (16% vs. 7%; p < 0,05). The polymorphism t174m of angiotensinogen gene AGT was investigated as one of the risk factor of alcoholic liver lesion. The allelic variant m of angiotensinogen gene AGT is more frequent (15.8%) in patients with alcoholic liver cirrhosis and alcohol abuse without cirrhosis (n = 98) than in population (6.7%, n = 52; p = 0.04). The highest frequency of allele m was in a group with alcoholic liver cirrhosis (17.3%; p = 0.058). Our data provides the evidence that polymorphism t174m of AGT gene does not influence the progression (clinical picture) of alcoholic liver cirrhosis, except the level of GGT, which is increased in patients with homozygous genotype tt.

50 patients with early manifestations of tick-borne borreliosis (Lyme-disease) with localized stage and mild and moderate clinical course were examined. It is established that early clinical and laboratory diagnostics and also timely prescription of antibiotics could to prevent the development of relapses and late complications.

The study studied the participation of toxoplasma gondii in the formation of antiphospholipid antibodies in pregnant women. The results showed that previous infection with toxoplasma gondii might lead to development antiphospholipid antibodies, which in turn might predispose to infertility, and abortion.

The article presents comparative results of total knee arthroplasty of two groups of patients for gonarthrosis 3-4 stage perfomed by standart and minimally invasive midvastus approaches (30 knee joints in each group). Advantages and differences of these methods are discussed. Early and late postoperative outcomes are analyzed. Minimally invasive midvastus approach for total knee arthroplasty reduces duration of rehabilitation of the patients with gonarthrosis and improves its results, especially in early postoperative period.

Teeth not exposed to chewing forces have a capacity for physiological tooth movement or tooth migration. The erupting tooth will erupt until it reaches occlusal contact and the final positioning of the teeth depends on the equilibrium between forces e. g. forces from the occlusion, tongue, lips and eruption. Therefore, overeruption is accommodation process. There are several methods to treat the disease: the intrusion by means of orthodontics appliances, selective alveolar corticotomy for intruding overerupted teeth, prosthetic crowns, tooth extraction. Surgical or orthodontic therapy may be inconvenient and they are not always as effective as desired. Available prosthetic options for restoration of occlusion include selective root canal treatment with invasive tooth reduction to reconstruct the occlusal plane and make enough places for porcelain fused to metal crowns. The alternative treatment was proposed by department of prosthodontics of Peoples' Friendship University of Russia. The only destroyed tooth is restored by ceramo-composite pinlay, thus making no changes in occlusion line. The indications for this method: orthodontic therapy is not effective, no blockage of jaw motions, no pathologic changes in temporomandibular joints.

The diastolic function of the the left and right ventricles in adolescents with constitutional-exogenous obesity (CEO) and in healthy adolescents was studied. Diastolic dysfunction of the E/A ≤ 1,5 of the both ventricles was revealed: the left ventricle - 23.2% and the right ventricle - 20.9%.

The methodology of obtaining micropreparations of propolis was developed, pollen spectrum 13 samples from different regions was studied. Frequency of pollen types in the samples of propolis was analyzed.

An algorithm of computer diagnostic rules clusterization is presented. It supports a possibility of rules interpretation as specialist's knowledge expansion tool.