Biological factors of alcoholic liver disease progression

P P Ogurtsov; Огурцов Павел Петрович; T S Polikarpova; Поликарпова Татьяна Сергеевна; I V Garmash; Гармаш Ирина Владимировна; O S Arisheva; Аришева Оьга Сергеевна; А E Guschin; Гущин Александр Евгеньевич; E V Tarasenko; Тарасенко Екатерина Владимировна; G I Myandina; Мяндина Галина Ивановна

Biological factors of alcoholic liver disease progression

Authors: Ogurtsov PP¹, Polikarpova TS¹, Garmash IV¹, Arisheva OS¹, Guschin АE¹, Tarasenko EV¹, Myandina GI¹
Affiliations:
1. Peoples Friendship University of Russia
Issue: No 3 (2012)
Pages: 26-30
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3609
Retraction date: 21.02.2018
Retraction reasons description:
The reason: duplicate publication (Journal of Scientific Articles Health and Education in the XXI Century. 2012. V. 14. No. 2. P. 140-141).

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Abstract

Aim: to detect the genetic factors predisposing alcoholic liver lesion. The main candidate genes of high risk are isoforms of adh and aldh genes which are responsible for different level of alcohol metabolism and oxidation of ethanol and acetaldehyde. Our results demonstrated that allelic variant adh2-2 is observed more frequently in patients with alcoholic liver damage than in population (16% vs. 7%; p < 0,05).
The polymorphism t174m of angiotensinogen gene AGT was investigated as one of the risk factor of alcoholic liver lesion. The allelic variant m of angiotensinogen gene AGT is more frequent (15.8%) in patients with alcoholic liver cirrhosis and alcohol abuse without cirrhosis (n = 98) than in population (6.7%, n = 52; p = 0.04). The highest frequency of allele m was in a group with alcoholic liver cirrhosis (17.3%; p = 0.058). Our data provides the evidence that polymorphism t174m of AGT gene does not influence the progression (clinical picture) of alcoholic liver cirrhosis, except the level of GGT, which is increased in patients with homozygous genotype tt.

Keywords

alcoholic liver cirrhosis, alcoholdehydrogenase, polymorphism adh2, polymorphism t174m, angiotensinogen gene AGT, the renin-angiotensin system

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Biological factors of alcoholic liver disease progression

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About the authors

P P Ogurtsov

T S Polikarpova

I V Garmash

O S Arisheva

А E Guschin

E V Tarasenko

G I Myandina

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