The importance of pharmacogenetic research for optimization of antihypertensive treatment

O V Shevchenko; Шевченко Ольга Валерьевна; E N Bychkov; Бычков Евгений Николаевич; O M Posnenkova; Посненкова Ольга Михайловна; P Ya Dovgalevsky; Довгалевский Павел Яковлевич; S I Bogoslovskaya; Богословская Светлана Ивановна; A A Svistunov; Свистунов Андрей Алексеевич

The importance of pharmacogenetic research for optimization of antihypertensive treatment

Authors: Shevchenko OV¹, Bychkov EN¹, Posnenkova OM², Dovgalevsky PY.², Bogoslovskaya SI¹, Svistunov AA³
Affiliations:
1. Saratov State Medical University n.a. V.I. Razumovsky
2. Saratov Research Institute of Cardiology
3. Research Institute of PharmacyFirst Moscow State Medical University n.a. M.I. Sechenov
Issue: No 3 (2012)
Pages: 95-100
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3622

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Abstract

As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.

Keywords

antihypertensive treatment, cytochrome P450, pharmacogenetics, biochips

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Vol 29, No 1 (2025)

The importance of pharmacogenetic research for optimization of antihypertensive treatment

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Abstract

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About the authors

O V Shevchenko

E N Bychkov

O M Posnenkova

P Ya Dovgalevsky

S I Bogoslovskaya

A A Svistunov

References

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