No 1 (2011)

On animal model of an acute hemodynamic overload of the left ventricle (LV) caused by the artificial aortic stenosis, some characteristics of left and right ventricular contractive activity and diastolic function were studied. It was found that a sudden increase in afterload leads to a significant reduction of contractive activity and potential working capacity of both ventricles. LV also suffers from diastolic dysfunction.

The article presents the results of the survey and treatment of 108 patients admitted with the clinical relapse of chronic critical ischemia of lower extremities that arose at different times after the primary reconstructive operations. In a special survey of patients revealed that 40.7% of cases there was an objective reason for the development of postoperative complications and recurrence of critical ischemia. All patients were operated on again in the light of the identified causes, preventive measures taken by the development of complications. Obtained good results - in 78,7% of cases arterial blood flow restored. The optimal method of repeated reconstructive interventions depending on the cause of relapse of chronic critical limb ischemia, developed indications and methods of combined treatment with the development of postoperative complications after the primary reconstructive interventions. It performs the following operations: resection of abdominal aortic aneurysm, aorto-bifemoralnoe prosthetics, multilevel bypass limb, femoral-tibial artery bypass technique «in situ», thrombectomy and autogenous vein anastomosis and profundoplasty.

Aim: to study lymphotropic antibiotics therapy for prevention of postoperative inflammatory complications after the surgery on the major joints. Two groups of patients were involved in this study. In the first group, prophylaxis of infection has been carried out according to traditional scheme including intravenous injections of antibiotics, whereas in the second group antibiotic therapy - through lymphotropic injections. Blood (erythrocytes) analyses had been doing in dynamics - prior to treatment, on the 3rd and 10th days after the operation. Strength of content of malon dialdehyde (MD) and systemic lipids have been measured in the red-cell membrane. Condition of antioxidant protection (AOP) has been evaluated according to the activity of superoxide dismutase (SD), catalase, glutathione peroxidase (GP) and glutathione reductase (GSR) enzymes. It is established that lymphotropic antiobiotic therapy allows to decrease in a greater degree the destructive effect of lipids peroxidation processes, to increase potential capacity of AOP enzymes, to restore barrier-filtration and transportation-drainage function of lymphatic vessels that favorably effects on the processes of reparation and physiological regeneration of damaged tissues.

Peculiarities of changes in free radical oxidation, endogenic intoxication and functional condition of liver were studied in patients with dysfunctional uterine bleeding at treatment with Progesteron and Utrogestan. It is shown that the level of free radical oxidation increases and the activity of antioxidant protection decreases on the background of elevated endogenic intoxication. It is accompanied by decrease of the liver protein synthetical function and increase activity of tracer enzymes - cytolyses markers. Progesteron increases endogenic intoxication and hypoalbuminemia on the background of increased activity of peroxide lipids oxidation in case of initial liver's function disorder. Utrogestan increases hypoalbuminemia on the background of increased activity of tracer enzymes along with decreased intensivity of peroxide lipids oxidation and preservation of depression of antioxidatic protection and endointoxication. These changes are necessary for considering at treatment planning.

The review deals with a problem of rational treatment of cardiovascular patients. There is increased percent of surviving patients after heart operations due to improvement of surgical technique and who require the subsequent dental treatment. To the present day, there are no universal approaches to investigation and management of such patients for outpatient dental practice.

The purpose - comparative investigation of influence of inhibitors hydroxy-methyllglutaril co-enzyme A-reductase - Fluvastatin, Lovastatin and Simvastatin on rheological properties of erythrocytes in patients with arterial hypertension and dyslipidemia. The total number of enrolled patients was 95 and all of them had arterial hypertension 1-2 degrees, risk 3 and dyslipidemia II type (recommendation VNOK, 2007). The average age of patients was 52,4 ± 2,6 yrs. The control group included 26 healthy people of similar age. Patients have been divided into 3 comparable, homogeneous groups according to administration either Fluvastatin or Lovastatin or Simvastatin for 12 months in each group. Administration of Fluvastatin and Lovastatin in patients with arterial hypertension with dyslipidemia within 1 year is capable to reduce activity lipid oxidations of lipids in erythrocyte membranes, its deformation changes and aggregation activity whereas the therapy by Simvastatin allows the erythrocyte activity to reach the values in control group.

The optimum preparation conditions (including the degree of the raw materials grinding, ethanol concentration, infusion time, preparation technique) of alcoholic extracts from Euphrasia, Melampyrum, Verbascum herbs providing the maximum yield of biologically active substances have been determined. The technology of dry and liquid Euphrasia extracts, liquid Melampyrum extract, dry Verbascum extract has been developed.

In this study we offer the special point system for evaluation of some changes of the eye in people of different age. Using this special point system, we examined 105 patients from 35 to 91 years old who were divided into 4 groups according to their age. The results showed different sums of points in the groups: I group - the mean sum of points was 36 points; II group -48 points; III group - 85 points; IV group - 97 points consequently. Degenerative changes of the eye's structures were proved by digital instrumental methods.

369 employees of extreme services (males) aged from 18 to 49 years were explored by Y. Strelau's method to assess the properties of higher nervous activity. According to the professional activity, three groups of people are identified whose work is related to the daily extreme conditions. Extended study of peculiarities of worker's nervous system properties of different professional groups in extreme activities was carry out in a sample of employees of the Ministry of Internal Affairs. It is revealed that professional groups carrying out activities in stressful working condition differed high indicators of force of nervous processes and their mobility. Specific parameters of nervous system are determined for different professional groups. The dynamics of nervous system during extreme professional service is revealed.

Dispersive mapping is a new method of the diagnostic electrocardiogram. In the basis of this method is the analysis of low amplitude fluctuations of ECG-signal, existing in norm and pathology. Results of the lead researches have allowed to designate a range of changes the parameters of a dispersion for healthy persons at loading and patients with ACS.

The article presents the data on death rate of rural and urban male population in the Republic of Bashkortostan in the 2008. The standardized indicators demonstrate that death rates from cancer, diseases of blood circulation and respiratory systems were higher among urban men. On the contrary, among rural men the mortality from traumas is considerably above.

Authors analyzed indicators of mortality in the population of Ufa city from 2002 to 2008. A mortality rate for all causes of death has decreased for both men and women, mainly from the external causes and disease of the respiratory system. An increase In the certain age groups: among men aged of 25-29, 30-34 and 65-69 years and among women of 30-34, 35-39 and 45-49 years this rate was increased.

The main feature of reproductive processes in republics of the North Caucasus is the increasing of birth rate. However adverse dynamics of perinatal losses does not allow to estimate unequivocally change, as positive. Despite of some positive tendencies, it is necessary to optimize the maternity obstetric service by creation of perinatal centers in each republic and improvement of quality of medical aid to the female population.

The growth of the old people's population is the reason for the increasing of requirement for the medical and social care and the financial resources. So, it is necessary to find a new organizational forms of rendering of such care. Author analyses the structure of medical and social care to the old people and its new forms as exemplified by one district of Saint-Petersburg. Special attention is paid to such forms, which permit to integrate the medical and the social services (the geriatric social - rehabilitation department, multidisciplinary team for the patients with strike and so on).

The author of the article considers sociological interpretation of success of doctor's professional innovative activity, proves necessity of comprehension of socio-cultural problems of innovations, on the basis of advanced achievements of sociology of medicine, strategy of innovative development of the country.

Experiment on 30 rats with the secondary immunodeficiency is conducted. On the dorsum of the back identical wounds were simulated. Rats were divided on groups, in a control group (a suspension was not used) and on 2 experimental groups (a suspension was used with the different concentrations of EGF). It was revealed that preparation of EGF + hydroxyapatite nanocrystals also has the ability to stimulate regeneration in case of immunodeficiency.

The article presents the results of investigation of the social characteristics of patients in therapeutical department of the municipal and central district hospitals. Influence of social status on appropriateness of hospitalization and suitable alternatives for in-patient care have been investigated.

The membraneous reactions of lipid peroxidation in women with phlebothrombosis of the lower extremities were studied. Increased level of malonic dialdehyde - product of POL, in erythrocytes and decreasing of enzymatic catalase activity in blood were revealed. It was supposed that one of the main causes of phlebothrombosis are destabilization and destruction of erythrocyte membranes due to disorders of POL.

Work is dedicated to description of the possibilities of the new method - dispersion mapping.