No 2 (2010)

Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.

Protective and normalizing mildronate action on the level of non enzyme kation proteins in the neurophils and contents of kateholamins in erythrocytes were revealed on the experimental model of the emotional-pain stress. The findings of numerous investigations demonstrate that positive effects of mildronate were connected not only with its metabolism-modifying action but with accumulated holinolike metabolites of karnitine and normalizing influence on the central parts of neuro-endocrine systems, which ensure its use with the aim of increasing of adaptation to the outer environmental factors as well at to the prolonged phycho-emotional overstrain.

Electrophysical properties of multicomponent heterogeneous systems containing polar liquid phase and electrically active inclusions are investigated while the study of human blood. It was found that the examined biological system has electret properties which are related to accumulation of interphase charges in the presence of inner electric field. Special attention is paid to the analysis of change of structure of water component in plasma near the interfaces. The existence of low-temperature current maximums whose dynamics is the same for all groups of blood and high-temperature current maximums which characterize individual properties of the biofluid in the range of temperatures (20-220) °C has been established. For the first time electrophysical parameters that describe physical properties of human blood thoroughly are determined.

Findings of the sensory-motor asymmetry investigation are presented in the paper. Four groups of students differentiated on the basis of the dominant hemispheric activation and dominance of the acoustic, visual and motor analyzers are studied, psychophysiological and electrophysiological peculiarities in the examined groups being determined. The individual lateral profile is established to influence the successful language mastering. Results obtained during the investigation point to the close correlations between functional hemispheric asymmetry, types of the higher nervous activity and students' academic achievement.

The effect of plasmapheresis is studied at placentary insufficiency at 120 women after IVF with placenta isufficiency. The age of investigated women was from 26 to 41 years, average 33,4 ± 4,6 years. Among which 60 pregnant treated traditionally, 60 pregnant were treated by plasmapheresis and traditionally. Plasmapheresis (PA) performed discontinuous way. In general, conducted 3 courses of treatment, at intervals of 3-4 days, under the dynamic performance of clinical and laboratory data. The results of our investigation showed that plasmapheresis and in combination with traditionally permits to improve the indications of fetoplacental system and promotes favorable perinatal outcome and pregnancy, labors complication reduced. Researches have shown that plasmapheresis, considerably improves a fetus condition to what the, of USI, Doppler ultrasound and perinatal effects testifies. Improvement of maternal - and perinatal outcomes is noted. Plasmapheresis is a prospective method of treatment allowing to, decrease medicinal loading on maternal and fetal organisms, to improve uterine- and feto-placental circulation, to lower an incidence of complications of pregnancy and delivery.

In this article clinical indexes of the dynamics of mineral bone density according to both densitometry and marker of resorption as well as bone formation and steroid blood hormons in patients in postovarioectomy are analysed. These patients state was complicated by cancer of the corpus and colli uterus after etiopathogenetic treatment including total husterectomy, radiation therapy and polychemotherapy. According the results of the comparative analysis in patients with postvarioectomic syndrome developed after surgical treatment for benign internal genitalia diseases we may make the conclusion on pathogenetic role of postovarioectomic syndrome in the development of bone disturbances in female patients which underwent total hysterectomy and special therapy.

The article presents a comparative analysis of standard echocardiography and tissue Doppler method Rings atrioventricular valves in patients with chronic heart failure with a view to early diagnosis of functional disorders of the myocardium. It is shown that, in connection with the ability to detect myocardial dysfunction in the earlier periods of chronic heart failure and the possibility of dynamic observation of patients during therapy, appropriate complement adopt routine echocardiography by tissue Doppler.

To study possibilities of improving of blood pressure (BP) control using the DENS device in patients with arterial hypertension stages I-II. Placebo-controlled study of antihypertensive effect of diaDENS-cardio in 60 patients with arterial hypertension taking regular antihypertensive therapy. Measurements of BP were performed by self BP control and 24 hours monitoring of BP. According to results of both self BP control (123,4 ± 5,4 vs 144,9 ± 7,4 мм рт.ст., p < 0,05) and 24 hours monitoring of BP (125,8 ± 4,9 vs 147,1 ± 11,7 mm Hg, p < 0,05) decrease in systolic BP in groups using device diaDENS-cardio was observed. Decrease in BP in patients using device diaDENS-cardio resulted in reduced doses of ACE (enalapril 7,8 ± 5,7 vs 19,7 ± 10,2 mg/days, p < 0,01) and beta-blockers doses (metoprolol 40,8 ± 19,1 vs 75,8 ± 35,6 mg/days, p < 0,05) for optimum BP control. Using of active device diaDENS-cardio in patients with arterial hypertension helps to attain targeted BP values with lower drug doses.

The Article presents the stages of rendering restoratory medicine medical aid. It proposes the procedure of in-patient as well out-patient and polyclinic treatment of individuals with risk factors and patients and the requirements for sending patients for restoratory treatment and medical rehabilitation. The Article proves that the enlargement of rehabilitation and restoratory treatment complex individual programs medical institutions network would make it possible to decrease the term of incapacity for work with acute diseases, disability, especially, among able-bodied population.

The use of conduit in the radical correction of complex congenital heart disease (CCHD), such as pulmonary atresia, ventricle septal defect (II type) with origin of left pulmonary artery from ascending aorta, is the operation of choice in the presence of anomalous origin of coronary arteries at anterior wall of right ventricular outflow tract (RVOFT).

524 patients with incarcerated wall hernias were studied. Postoperative complication rate was 19,9%, mortality rate was 8,6%. Recurrence rate was 18,6%. It depends on intraabdominal pressure and function of the external respiration. Tension-free repair appears to be safe, and is proving to be effective as it decreases intraabdominal pressure, complications, recurrences, and mortality rate.