No 4 (2011)

Here the presence of a chronomodulating actions of melatonin via feedsideawards mechanism in vitro as well as, in vivo, in two experimental models was presented. Intriguing process of how this takes place may due to an interacting pineal pituitary-adrenal networks (1). In vivo studies confirmed the role of melatonin in the study on Meth-A-sarcoma in mice and in LOU tumor growth. Melatonin disrupted circadian time structure of in vivo tumor growth on a feedsideawards manner in the case of the immunocytoma growth in female inoculated rats. Low doses disrupted the circadian DNA synthesis of mF-cells. Drug delivery systems must be taken in consideration the role of melatonin feedsideawards involvement during chronomodulated therapy of cancer patients.

In order to recognizing early to reveal early metabolic changes in experimental alcoholic pancreatitis and possibility for their correction. Some parameters of glycolysis and antioxidant protective system of rats' erythrocytes were investigated. It was revealed that experimental pancreatitis associated with progressive tissue hypoxia and antioxidant misbalance. Administration of Tykveol (pumpkin seed oil) prevents metabolic changes.

Group antigens of red blood cells are not only markers of blood groups, but also have different functions: receptor, transport, regulatory, trophic, immune, etc. The human genome has a gene locus ABO, which determines the blood group and regulates synthesis of the corresponding antigens. Genes A and B do not produce antigens directly, and their direct products are enzymes - glycosyltransferases. Transferases are able to attach the respective residues of glucose to the H-antigen galactose, thereby forming antigens A, B or AB. A and B antigens are heterogeneous in their structure and can be manifested in a number of different allotype. The main feature of the ABO system is the presence of natural antibodies to the missing red blood cell's antigen in plasma. In the interaction of antigen with antibody, both compounds exert mutual influence on their own conformation.

Currently diseases of cardiovascular system rank the leading place in the structure of mortality of the population in industrialized countries. The basis of this nosology is atherosclerotic vascular lesions. Active search for the etiological factors, initiating the development of atherosclerosis, leads to new hypotheses. However, today any of declared is not aprioristic. Chronic inflammation supported by persistency of Chlamidia pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, Herpes simplex types 1 and 2 promotes activation of the endothelium, leading to its metabolic parameter changes that influence the lipid metabolism, and thus participates in the development of atherosclerotic lesions.

Work is devoted to research dynamics of parameters of high resolution ECG (HRECG) and heart rate variability (HVR) methods in patients with acute coronary syndrome in determining myocardial electrical instability and disease trend the carried out. The researches have shown that, the HRECG and HRV variables in acute coronary syndrome, patients have various possible changes, which correlate with the severity of the current disease.

2958 patients with inguinal hernias are operated on. There were 2720 (91,95%) males and 238 (8,05%) females. The patient's age was from 18 till 86 years. Relapse of hernia occurred in 409 (17,4%) from 2351 patients after tension hernioplasty. From 2003 till 2010 yy 607 operations with the use mesh endoprosthetics are performed and relapse of hernia was observed in 6 (2,6%) patients. It is proved, that in case of imperfect inguinal ligament the threat of relapse increases in 4,5 times. Method of reconstruction of inguinal ligament in case of recurrent hernias, providing reliable hernioplasty, is developed.

Thymoma is a rare tumor of mediastinum, which incidence is less than 1% of all oncological diseases, and 10-20% of primary mediastinum lesions. Current WHO classification (Masaoka staging and histological tumor type) does not allow to determine the necessity for additional methods of treatment and to predict the further development of disease. The developed individual prognostic system for disease progression probability assessment, based on certain criteria, is a simple and cheap prognostic method in patients with thymoma.

The prognostic value of the expression Ki-67, ММР-9 and collagen IV in urotelial bladder tumors were estimated. The biopsy and surgery samples from 43patients (27males and 16 females) aged from 42 till 87 years (average age 66 ± 1,5 years) who received combined therapy for urotelial tumors were analyzed. It has been found that Ki-67, ММР-9 and collagen IV are important prognostic markers of urotelial invasive bladder carcinoma (BC).

The article deals with the effect of laser acupuncture and Kurantil (Dipyridamole) on uteroplacental hemodynamics in pregnant women with arterial hypertension (AH). Positive effects of laser radiation and Kurantil in the complex treatment of hypertensive pregnant women were proved: normalization of blood flow in uteroplacental complex was observed.

Influence of virus load, the beginning and the regimen of specific antiretroviral (AVR) prophylaxis on expression of destructive and adaptive changes in placental bed structures of the uterus during HIV-associated pregnancy is studied. 61 HIV-infected pregnant women from 17 till 41 years were surveyed. It is proved, that in the placental bed specimens collected during SC in HIV-infected women, the focal chronic deciduitis took place which morphologically correlated with prolonged pre-conceptional persistency of infection. Increasing of the virus load led to elevation of inflammatory cells and destructive changes. With increasing duration of AVR prophylaxis and administration of highly active antiretroviral therapy (HAART) the areas of necrosis and fibrosis were enlarged, atrophic changes in the decidual tissue were observed. Statistical analysis has allowed to find out that virus load, duration and the therapeutic regimen determine severity of destructive processes in uterine placental bad and realization of adaptive reactions that promote the development of placental insufficiency during HIV-associated pregnancy.

In the work, the impact of general air cryotherapy on a water homeostasis in healthy volunteers is estimated. It is revealed that along with the duration of exposure the redistribution of water forms with an increase of associated fraction took place. This character of metabolic processes testifies to adaptive impact of cold stress on rheologic properties of blood.

The results of interviewing of 35 medical workers and 120 patients who applied to the hospitals for identifying the quality and accessibility of provision of health care are presented.

Comparative investigation of effects of diuretic medication Furosemide on the rat renal function was carried out after short-term and long-term keeping the animals under condition of light (subjective day) and darkness (subjective night). It was found that administration of Furosemide has induced more powerful diuretic and natriuretic effects in rats during subjective night. It was assumed that in rats, which are the nocturnal animals, such differences are caused by more expressive renal functional activity at night.

Article presents the results of studies on separation of Zolpidem from biological substrates by methods of extraction chromatography (in a think layer) and UV-spectrophotometry.

The effects of T-activin, the thymus-derived polypeptide, on the content level of monoamines and their metabolites in frontal cerebral cortex, striatum, hypothalamus, nucleus accumbens and hippocampus of rats under emotional stress conditions using HPLC technique have been studied. The substance was shown to reduce the indices of emotional tension and to improve adaptation in stressful conditions at rats that may be the evidence of the anxiolytic action of T-activin. It may be suggested that the positive influence of the thymus polypeptide manifested on the serotonin/norepinehrine balance in favor of the first in hypothalamus and frontal cerebral cortex.

The analysis of clinical progression and treatment of gallstone small bowel obstruction in 44 patients is given. The variants of diagnosis and outcomes of operations are presented.