No 4 (2011)


Hormone secreted by the pineal gland - melatonin feedsideward involvement in cancer growth

Salvador Sanchez-de la Pena -., Chibisov S.M., Kirichek A.A., Kharlitskaya E.V., Frolov V.A.


Here the presence of a chronomodulating actions of melatonin via feedsideawards mechanism in vitro as well as, in vivo, in two experimental models was presented. Intriguing process of how this takes place may due to an interacting pineal pituitary-adrenal networks (1). In vivo studies confirmed the role of melatonin in the study on Meth-A-sarcoma in mice and in LOU tumor growth. Melatonin disrupted circadian time structure of in vivo tumor growth on a feedsideawards manner in the case of the immunocytoma growth in female inoculated rats. Low doses disrupted the circadian DNA synthesis of mF-cells. Drug delivery systems must be taken in consideration the role of melatonin feedsideawards involvement during chronomodulated therapy of cancer patients.
RUDN Journal of Medicine. 2011;(4):7-15
pages 7-15 views

Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

Torshin V.I., Smirnov V.M., Sveshnikov D.S., Kuchuk A.V., Yurasova I.A.


This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both glossopharyngeal nerves. Mechanical activity of the stomach was recorded during serotonin adipanate infusion to intact animals and on the background of the ongoing actions of cholinergic and adrenergic antagonists. The blockade of adrenergic and cholinergic receptors does not prevent, but contrary, increase stimulatory effect of serotonin. β-adrenergic blockade increases the intensity of observed reactions almost up to 90%. Conclusion: both adrenergic and cholinergic mechanisms provide inhibitory pattern on serotoninergic structures that regulates motor function of the stomach.
RUDN Journal of Medicine. 2011;(4):16-21
pages 16-21 views

Metabolic changes in erythrocytes at experimental alcoholic pancreatitis and their correction

Letounovski А.V., Мiкаshinowich Z.I.


In order to recognizing early to reveal early metabolic changes in experimental alcoholic pancreatitis and possibility for their correction. Some parameters of glycolysis and antioxidant protective system of rats' erythrocytes were investigated. It was revealed that experimental pancreatitis associated with progressive tissue hypoxia and antioxidant misbalance. Administration of Tykveol (pumpkin seed oil) prevents metabolic changes.
RUDN Journal of Medicine. 2011;(4):22-24
pages 22-24 views

Biochemical markers of complicated and unfavorable prognosis in patients with acute coronary syndrome

Tourna A.A., Devichensky B.M.


Prediction of complications and outcomes of myocardial infraction is one of the most actual problems of cardiology for many years. With a wide choice of treatment methods myocardial infarction remains a main task for revealing the high risk patients of development of complications and unfavorable outcomes. Detection of cardio-specific biomarkers for revealing of high risk patients is widely used in the modern cardiological practice for a long time. The laboratory diagnosis of the disease in its early stages permits to identify patients with the acute coronary syndrome, unstable stenocardia and subsequently to predict outcomes of the main disease.
RUDN Journal of Medicine. 2011;(4):25-30
pages 25-30 views

Polymorpnism and multifunctionality of blood group antigens

Ryskina E.A., Chernov N.N., Epifanova A.A., Nefedova N.C.


Group antigens of red blood cells are not only markers of blood groups, but also have different functions: receptor, transport, regulatory, trophic, immune, etc. The human genome has a gene locus ABO, which determines the blood group and regulates synthesis of the corresponding antigens. Genes A and B do not produce antigens directly, and their direct products are enzymes - glycosyltransferases. Transferases are able to attach the respective residues of glucose to the H-antigen galactose, thereby forming antigens A, B or AB. A and B antigens are heterogeneous in their structure and can be manifested in a number of different allotype. The main feature of the ABO system is the presence of natural antibodies to the missing red blood cell's antigen in plasma. In the interaction of antigen with antibody, both compounds exert mutual influence on their own conformation.
RUDN Journal of Medicine. 2011;(4):31-36
pages 31-36 views

Expression of apoptosis receptors on the cells in patients with herpes infections

Kharaeva Z.F., Shevchenko А.А.


Expressions of CD95 receptors on the leukocytes in patients with HSV-1,2 infection as well as on the cervical cells was decreased (р < 0,05). No significant changes of expression of CD95 receptor in patients with cytomegalovirus were revealed.
RUDN Journal of Medicine. 2011;(4):37-39
pages 37-39 views

Viral and bacterial infections and coronary atherosclerosis

Minevich U.V., Burmistrov V.G., Prokopenko V.D.


Currently diseases of cardiovascular system rank the leading place in the structure of mortality of the population in industrialized countries. The basis of this nosology is atherosclerotic vascular lesions. Active search for the etiological factors, initiating the development of atherosclerosis, leads to new hypotheses. However, today any of declared is not aprioristic. Chronic inflammation supported by persistency of Chlamidia pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, Herpes simplex types 1 and 2 promotes activation of the endothelium, leading to its metabolic parameter changes that influence the lipid metabolism, and thus participates in the development of atherosclerotic lesions.
RUDN Journal of Medicine. 2011;(4):40-43
pages 40-43 views

CASPASE-3 and CASPASE-8 activity in right ventricular myocardial cells in experimental arterial hypertension

Azova M.M., Blagonravov M.L., Frolov V.A.


Caspase-3 and caspase-8 activity in right ventricular myocardial cells of rabbits with experimental arterial hypertension (AH) was investigated. Caspase-3 activity significantly increased at 2 and 4 weeks after modeling of AH. Obtained data demonstrated increased apoptosis in right ventricular myocardial cells in experimental arterial hypertension. Absence of significant increasing of caspase-8 activity indicates the predominance of intrinsic apoptogenic signals.
RUDN Journal of Medicine. 2011;(4):44-47
pages 44-47 views

The use of high resolution ECG and Heart rate variability methods in diagnosing of myocardial electrical instability in patients with acute coronary syndrome

Maha M., Ahmed Elgaili Ahmed -., Dvornikov V.E., Aleksandrova M.R., Kuznetsova S.Y., Agafoshina E.V., Ivanov G.G.


Work is devoted to research dynamics of parameters of high resolution ECG (HRECG) and heart rate variability (HVR) methods in patients with acute coronary syndrome in determining myocardial electrical instability and disease trend the carried out. The researches have shown that, the HRECG and HRV variables in acute coronary syndrome, patients have various possible changes, which correlate with the severity of the current disease.
RUDN Journal of Medicine. 2011;(4):48-57
pages 48-57 views

Function of rosella formed limphocytes and citokines in patient with chronic obstructive pulmonary disease

Pavlenko V.I., Naryshkina S.V.


The article is devoted to the peculiarities of cytokines (IL) affects on the kinetics of rosella formed lymphocytes (RFL) in 38 patients with chronic obstructive pulmonary disease (COPD). It is established that proinflammatory IL has depressiveу affect on rosella formed capacity of lymphocytes and promotes the development of immunodeficient condition.
RUDN Journal of Medicine. 2011;(4):58-60
pages 58-60 views

Surgical treatment of recurrent inguinal hernias

Mizaushev B.A., Kumishev A.N.


2958 patients with inguinal hernias are operated on. There were 2720 (91,95%) males and 238 (8,05%) females. The patient's age was from 18 till 86 years. Relapse of hernia occurred in 409 (17,4%) from 2351 patients after tension hernioplasty. From 2003 till 2010 yy 607 operations with the use mesh endoprosthetics are performed and relapse of hernia was observed in 6 (2,6%) patients. It is proved, that in case of imperfect inguinal ligament the threat of relapse increases in 4,5 times. Method of reconstruction of inguinal ligament in case of recurrent hernias, providing reliable hernioplasty, is developed.
RUDN Journal of Medicine. 2011;(4):61-64
pages 61-64 views

Short-term results of surgical treatment of retroperitoneal tumours

Kharchenko V.P., Chhikvadze V.D., Abdullaeva A.A., Sdvizhkov A.M.


Retroperitoneal tumours arre rare and compose 0,01-0,3% of all tumours types. The basic method of retroperitoneal tumour treatment is surgical resection which is carried out in 43-95% of patients. In this study we present analysis of surgical treatment of 104 patients with retroperitoneal tumours. Complited resection was made in 87 patients (83,7%); partial surgical resection - in 7 patients (6,7%), explorative laparotomyes have been executed in 8 patients (7,7%), symptomatic operations - 2 patients (1,9%). Operability percentage - 88,1%. Resectobility - 90,3%. Level of an intraoperation and postoperation complications was 29,8% and hospital lethality - 4,2%. Analysis of surgical treatment direct resultstestifies to high indicators of operability of patients with retroperitoneal tumours resectobility. Surgical treatment of retroperitoneal tumours isn't accompanied with high frequency of postoperative complications and lethality.
RUDN Journal of Medicine. 2011;(4):65-69
pages 65-69 views

Criteria for 5 years survival prognosis in patients with thymus tumors

Kolesnikov P.G., Goncharov S.V., Yadikov O.A., Chkhikvadze V.D.


Thymoma is a rare tumor of mediastinum, which incidence is less than 1% of all oncological diseases, and 10-20% of primary mediastinum lesions. Current WHO classification (Masaoka staging and histological tumor type) does not allow to determine the necessity for additional methods of treatment and to predict the further development of disease. The developed individual prognostic system for disease progression probability assessment, based on certain criteria, is a simple and cheap prognostic method in patients with thymoma.
RUDN Journal of Medicine. 2011;(4):70-75
pages 70-75 views

Conservative treatment of complications after integrated therapy of bladder cancer

Kaprin A.D., Ivanov S.A., Garmash S.V., Shestakov A.V.


Aim: to evaluate efficacy of systemic and local ozone therapy for correction of radiation complications after complex therapy of bladder cancer. Materials & methods: 25 patients with bladder cancer at the stage T2-Т3аN0M0 treated in FSI Russian Scientific Rentgenradiology Centre (from 2003 to 2008) were included in the study. The first group (12 patients) for the treatment of late complications received complex therapy for 3 months, the second group (13 patients) - standard symptomatic therapy. Results: the control study in 12 months showed a significant decline of total score of IPSS and QoL in the first group in comparison with the second one (17.5 ± 5.2 vs 23.5 ± 6 and 3.1 ± 1.1 vs 3.8 ± 1.5, respectively). Conclusions: for prevention and correction of radiotherapy complications of bladder cancer it is necessary to use additional methods of treatment including ozone therapy and pharmacotherapy which permit to improve the quality of patient's life.
RUDN Journal of Medicine. 2011;(4):76-79
pages 76-79 views

Diagnostic and prognostic importance of Ki-67, MMP-9 and collagen iv immunohistochemical markers in bladder tumors

Avdoshin V.P., Kotelnikova E.V., Babichenko I.I.


The prognostic value of the expression Ki-67, ММР-9 and collagen IV in urotelial bladder tumors were estimated. The biopsy and surgery samples from 43patients (27males and 16 females) aged from 42 till 87 years (average age 66 ± 1,5 years) who received combined therapy for urotelial tumors were analyzed. It has been found that Ki-67, ММР-9 and collagen IV are important prognostic markers of urotelial invasive bladder carcinoma (BC).
RUDN Journal of Medicine. 2011;(4):80-86
pages 80-86 views

Significance of the focal brain lesion in development of vestibular and acoustical disturbances in patients with multiple sclerosis

Kirichenko I.M., Popaduk V.I., Dayhes N.A., Alekseeva N.S., Arzumanyan N.S., Klochkov A.M.


We have examined 72 patients aged from 18 till 62 with cerebral and cerebrospinal multiple sclerosis (MS) form. All patients have been underwent оtoneurologiс examination, electronystagmography (ENG), caloric tests, pure-tone audiometry, high frequency audiometry up to 20 kHz, impedance audiometry, auditory brainstem responses (ABR), magnetic resonance imaging (MRI). 59 patients had pathologically changed in MRI demyelination lesion in the brainstem. Demyelinization of the brainstem affects acoustical and vestibular function in patients with multiple sclerosis. Pathological changes of pure-tone audiometry, high frequency audiometry, acoustic reflexes and ABR may be regarded as subclinical signs of demyelinization of the cochleovestibular analyzer.
RUDN Journal of Medicine. 2011;(4):87-93
pages 87-93 views

Correction of uteroplacental circulation in pregnant women with arterial hypertension

Kuzminа O.A., Peshev L.P.


The article deals with the effect of laser acupuncture and Kurantil (Dipyridamole) on uteroplacental hemodynamics in pregnant women with arterial hypertension (AH). Positive effects of laser radiation and Kurantil in the complex treatment of hypertensive pregnant women were proved: normalization of blood flow in uteroplacental complex was observed.
RUDN Journal of Medicine. 2011;(4):94-97
pages 94-97 views

Improvement of quality of life in women with cervical pathology by developing the treatment methods

Murakov S.V., Ivanov U.A., Veredchenko A.V., Popkov S.A., Pustovalov D.A., Fisenko V.V.


The article deals with highly effective technique in the treatment of persistent chronic endocervitsitis after plastic surgery. It shows the relationship between the pro-inflammatory cytokines of cervical mucus and the nature of the inflammatory process of endocervix in case of cervix deformation. This article describes reliable prognostic criteria for the development of chronic persistent cervicitis after plastic surgery.
RUDN Journal of Medicine. 2011;(4):98-102
pages 98-102 views

Clinical and morphological features of hiv-associated pregnancy

Rymashevsky A.N., Opruzhenkov A.V., Terekhina L.A., Kovaleva E.A., Voronova O.V.


Influence of virus load, the beginning and the regimen of specific antiretroviral (AVR) prophylaxis on expression of destructive and adaptive changes in placental bed structures of the uterus during HIV-associated pregnancy is studied. 61 HIV-infected pregnant women from 17 till 41 years were surveyed. It is proved, that in the placental bed specimens collected during SC in HIV-infected women, the focal chronic deciduitis took place which morphologically correlated with prolonged pre-conceptional persistency of infection. Increasing of the virus load led to elevation of inflammatory cells and destructive changes. With increasing duration of AVR prophylaxis and administration of highly active antiretroviral therapy (HAART) the areas of necrosis and fibrosis were enlarged, atrophic changes in the decidual tissue were observed. Statistical analysis has allowed to find out that virus load, duration and the therapeutic regimen determine severity of destructive processes in uterine placental bad and realization of adaptive reactions that promote the development of placental insufficiency during HIV-associated pregnancy.
RUDN Journal of Medicine. 2011;(4):103-108
pages 103-108 views

Change of the functional tooth pulp condition and paradontal tissues under controlled chewingactivity

Beglyuk D.A., Shevchenko D.P.


On the basis of clinical and physiological researches reographic indicators of tooth pulp and paradontal tissues under fixed dentures in patients of different age groups with partial secondary adentia under controlled chewing activity are presented. The analysis of obtained data allows to work out recommendations for planning of orthopedic treatment of partial adentia, the time of replacement of fixed orthopedic devices.
RUDN Journal of Medicine. 2011;(4):109-113
pages 109-113 views

Change of different forms of water of blood after general air cryotherapy

Hodarev N.V., Zhinko M.N., Evtushenko B.E., Solonchenko Y.Y., Olempieva Е.V.


In the work, the impact of general air cryotherapy on a water homeostasis in healthy volunteers is estimated. It is revealed that along with the duration of exposure the redistribution of water forms with an increase of associated fraction took place. This character of metabolic processes testifies to adaptive impact of cold stress on rheologic properties of blood.
RUDN Journal of Medicine. 2011;(4):114-116
pages 114-116 views

Markers of individual sensitivty to the environment pollutants

Prokhorov N.I., Smirnov S.V.


This work is devoted to investigation of markers of occupational respiratory allergens of chemical or biological nature as specific indicators of individual sensitivity of the working population employed in hazardous industry.
RUDN Journal of Medicine. 2011;(4):117-119
pages 117-119 views

Improvement of primary branch of public health care

Popov A.V., Shtunder O.Y.


The results of interviewing of 35 medical workers and 120 patients who applied to the hospitals for identifying the quality and accessibility of provision of health care are presented.
RUDN Journal of Medicine. 2011;(4):120-122
pages 120-122 views

Assessment of the environmental risk factors in the pathology of the thyroid gland (on the example of the moscow agglomeration)

Rustembekova S.A.


The role of environmental factors in the development of the thyroid gland's pathology is analyzed. 156 patients of 16-82-year-old living in Moscow have been surveyed. The analysis of an ecological condition of the city has helped to define the areas with the raised incidence rate of the thyroid gland's diseases. On an example of the Moscow agglomeration, the urgency of improvement of ecological and geochemical estimation of area pollution and search of new bio-indicators is shown. Territories with an optimum condition for human vital activity are revealed.
RUDN Journal of Medicine. 2011;(4):123-127
pages 123-127 views

Renal effect differences of furosemide in rats during subjective day and subjective night

Zvereva A.Y.


Comparative investigation of effects of diuretic medication Furosemide on the rat renal function was carried out after short-term and long-term keeping the animals under condition of light (subjective day) and darkness (subjective night). It was found that administration of Furosemide has induced more powerful diuretic and natriuretic effects in rats during subjective night. It was assumed that in rats, which are the nocturnal animals, such differences are caused by more expressive renal functional activity at night.
RUDN Journal of Medicine. 2011;(4):128-130
pages 128-130 views

Hypoglycemic activity of pectoinuline with taurine

Zyablitseva N.S., Kompantsev V.A., Kisieva M.T., Belousova A.L., Vasilenko Y.K.


Influence of Pectoinuline, received by aqueous-enzymatic method from tubers of Jerusalem artichoke, and its combinations with Taurine on blood glucose level in animals after administration course and animals with alloxan diabetes was investigated. Glucose level after administration of Pectoinuline without Taurine and with Taurine at healthy animals significantly has not changed, there was only a tendency to decreasing of glucose level in blood. In animals with alloxan diabetes administration of Pectoinuline with Taurine reduces glucose level to the greatest degree.
RUDN Journal of Medicine. 2011;(4):131-134
pages 131-134 views

Isolation of zolpidem from biological substrats

Khomov Y.A., Egorova E.I., Dayeh M.


Article presents the results of studies on separation of Zolpidem from biological substrates by methods of extraction chromatography (in a think layer) and UV-spectrophotometry.
RUDN Journal of Medicine. 2011;(4):135-138
pages 135-138 views

Wound healing properties of ointments with different copper nanoparticles containing

Rakhmetova A.A., Bogoslovskaya O.A., Ganzhigaeva A.N., Mbasha M.J., Olkhovskaya I.P., Glushchenko N.N.


Wound healing activity of ointments on the methylcellulose base containing various concentrations of copper nanoparticles is presented. It was found that the optimal effect on healing process has the ointment containing 0,002% of copper nanoparticles.
RUDN Journal of Medicine. 2011;(4):139-142
pages 139-142 views

The mechanism of action of thymus-derived polypeptide (t-activin) in experimental emotional stress model: a neurochemical study

Kiseleva N.M., Novoseletskaya A.V., Inozemtsev A.N., Kudrin V.S., Klodt P.M., Narkevich V.B., Zimina I.V., Arion V.Y.


The effects of T-activin, the thymus-derived polypeptide, on the content level of monoamines and their metabolites in frontal cerebral cortex, striatum, hypothalamus, nucleus accumbens and hippocampus of rats under emotional stress conditions using HPLC technique have been studied. The substance was shown to reduce the indices of emotional tension and to improve adaptation in stressful conditions at rats that may be the evidence of the anxiolytic action of T-activin. It may be suggested that the positive influence of the thymus polypeptide manifested on the serotonin/norepinehrine balance in favor of the first in hypothalamus and frontal cerebral cortex.
RUDN Journal of Medicine. 2011;(4):143-148
pages 143-148 views

Our experience of surgical treatment of calculous obstructive jaundice

Majorov M.M.


The analysis of efficacy and safety of different biliary decompression methods in patients with cholelithiasis complicated by obstructive jaundice is described.
RUDN Journal of Medicine. 2011;(4):149-151
pages 149-151 views

Clinical features of small bowel biliary ileus

Ogorodnikov V.A.


The analysis of clinical progression and treatment of gallstone small bowel obstruction in 44 patients is given. The variants of diagnosis and outcomes of operations are presented.
RUDN Journal of Medicine. 2011;(4):152-153
pages 152-153 views

Our authors

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RUDN Journal of Medicine. 2011;(4):154-160
pages 154-160 views

Pravila oformleniya i podgotovki stateyv Vestnik RUDN, seriya «Meditsina»

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RUDN Journal of Medicine. 2011;(4):161-163
pages 161-163 views

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