Hormone secreted by the pineal gland - melatonin feedsideward involvement in cancer growth

- Salvador Sanchez-de la Pena; Сальвадор Санчес де ла Пена -; S M Chibisov; Чибисов Сергей Михайлович; A A Kirichek; Киричек Андрей Андреевич; E V Kharlitskaya; Харлицкая Елена Валентиновна; V A Frolov; Фролов Виктор Алексеевич

Hormone secreted by the pineal gland - melatonin feedsideward involvement in cancer growth

Authors: Salvador Sanchez-de la Pena -¹, Chibisov SM², Kirichek AA², Kharlitskaya EV², Frolov VA²
Affiliations:
1. Chronomics Research Center-Escuela Nacional de Homeopatía-IPN
2. Peoples' Friendship University of Russia
Issue: No 4 (2011)
Pages: 7-15
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3552

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Abstract

Here the presence of a chronomodulating actions of melatonin via feedsideawards mechanism in vitro as well as, in vivo, in two experimental models was presented. Intriguing process of how this takes place may due to an interacting pineal pituitary-adrenal networks (1). In vivo studies confirmed the role of melatonin in the study on Meth-A-sarcoma in mice and in LOU tumor growth. Melatonin disrupted circadian time structure of in vivo tumor growth on a feedsideawards manner in the case of the immunocytoma growth in female inoculated rats. Low doses disrupted the circadian DNA synthesis of mF-cells. Drug delivery systems must be taken in consideration the role of melatonin feedsideawards involvement during chronomodulated therapy of cancer patients.

Keywords

melatonin, feedsideward, chronomodulating actions, pineal pituitary-adrenal networks, LOU tumor, circadian DNA synthesis

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Vol 28, No 4 (2024): ONCOLOGY

Hormone secreted by the pineal gland - melatonin feedsideward involvement in cancer growth

Full Text

Abstract

Keywords

About the authors

- Salvador Sanchez-de la Pena

S M Chibisov

A A Kirichek

E V Kharlitskaya

V A Frolov

References

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