Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

V I Torshin; Торшин Владимир Иванович; V M Smirnov; Смирнов В М; D S Sveshnikov; Свешников Д С; A V Kuchuk; Кучук А В; I A Yurasova; Юрасова И А

Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

Authors: Torshin VI¹, Smirnov VM², Sveshnikov DS², Kuchuk AV², Yurasova IA²
Affiliations:
1. Russian Peoples' Friendship University
2. Russian State Medical University
Issue: No 4 (2011)
Pages: 16-21
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3553

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Abstract

This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both glossopharyngeal nerves. Mechanical activity of the stomach was recorded during serotonin adipanate infusion to intact animals and on the background of the ongoing actions of cholinergic and adrenergic antagonists. The blockade of adrenergic and cholinergic receptors does not prevent, but contrary, increase stimulatory effect of serotonin. β-adrenergic blockade increases the intensity of observed reactions almost up to 90%. Conclusion: both adrenergic and cholinergic mechanisms provide inhibitory pattern on serotoninergic structures that regulates motor function of the stomach.

Keywords

serotoninergic structures, serotonin, stomach, adrenergic, cholinergic receptors

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

Full Text

Abstract

Keywords

About the authors

V I Torshin

V M Smirnov

D S Sveshnikov

A V Kuchuk

I A Yurasova

References

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