Polymorpnism and multifunctionality of blood group antigens

E A Ryskina; Рыскина Е А; N N Chernov; Чернов Николай Николаевич; A A Epifanova; Епифанова А А; N C Nefedova; Нефедова Н С

Polymorpnism and multifunctionality of blood group antigens

Authors: Ryskina EA¹, Chernov NN¹, Epifanova AA², Nefedova NC²
Affiliations:
1. Peoples' Friendship University of Russia
2. State Medical University of Samara
Issue: No 4 (2011)
Pages: 31-36
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3556

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Abstract

Group antigens of red blood cells are not only markers of blood groups, but also have different functions: receptor, transport, regulatory, trophic, immune, etc. The human genome has a gene locus ABO, which determines the blood group and regulates synthesis of the corresponding antigens. Genes A and B do not produce antigens directly, and their direct products are enzymes - glycosyltransferases. Transferases are able to attach the respective residues of glucose to the H-antigen galactose, thereby forming antigens A, B or AB. A and B antigens are heterogeneous in their structure and can be manifested in a number of different allotype. The main feature of the ABO system is the presence of natural antibodies to the missing red blood cell's antigen in plasma. In the interaction of antigen with antibody, both compounds exert mutual influence on their own conformation.

Keywords

ABO blood group, antigen, antibody, glycosyltransferases

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Polymorpnism and multifunctionality of blood group antigens

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Abstract

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About the authors

E A Ryskina

N N Chernov

A A Epifanova

N C Nefedova

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