No 3 (2011)

Carotid glomectomy is an adequate method for studying the functional role of peripheral chemoreceptors in the regulation of body functions. After glomectomy in animals the blood glucose level increases, respiratory rate decreases, oxygen consumption and carbon footprint signs of anaemia develops. The results suggest the possibility of physiological correction of the level of glycemia and gas exchange in animals during periodic action of hypoxia, hypo- or hyperthermia after glomectomy.

This work executed on a model of endothelial monolayer in vitro, is devoted to the study of mechanisms leading to endothelial barrier dysfunction. The dysfunction inductor, thrombin, acts on endothelial cells through a specific receptor, triggering cascades of intracellular reactions (including cytoskeletal reorganization) resulting to increased of endothelial permeability. Thrombin-receptor interaction leads to dissociation of heterotrimeric G-protein subunits (Gi, Gq and G12/13), each of which is potentially capable to handle one or more possible ways of dysfunction development. In the present study we analyzed the role of Gi protein in the occurrence of cytoskeletal disturbances that lead to barrier dysfunction. According to our results, it can be assumed that the activity of Gi protein does not directly affect on the endothelial barrier properties.

The article deals with the testing of phytoestrogens containing in plants endemic to Chile. This research confirms that phytoextract has the similar effect upon the target-tissues like estradiol. It was detected, that this substance inhibits the stimulating action of estradiol over the population of lactobacillus in vagina.

The concept-formats of the automated network resource for degree candidates and their supervisors is discussed. The system helps to design the experiment, collect and analyze data. It can be used for motivation of candidates during preparation of scientific thesis.

In this thesis conceptual model of adaptation (kinesis) syndromes of traumatic stress situation was proposed including information models of acute (traumatic) and chronic (sports or professional) overloaded and acute (premorbid) and chronic (senile) hypokinesis adaptation syndromes, which allow to prognoses the stage of traumatic disease and acute hypokinesia at molecular, cellular, organic and organism levels.

The article presents the use of hirudoreflexotherapy, acupuncture, magnitorexlexotherapy in medical rehabilitation of elderly patients. It is noticed that hirudoreflexotherapy it is the most effective method in patients with an arterial hypertension of 1 degree, magnitoreflexotherapy - in patients with an arterial hypertension of 2 degrees.

Chronic hepatitis С - one of the most widespread bloodborne infections in the world, which represents an important problem as one of the frequent causes of disability of young patients and indications to liver transplantation. One of the less studied, but extremely actual problems is eventual influence of the lipid exchange disturbances on the results of combined antiviral therapy. Influence of hypercholesterinemia on chronic HCV-infection and results of antiviral therapy are not studied enough and have certain scientific and practical value. 144 adults (> 18 years) with HCV-infection, who have passed their first course of antiviral therapy with PegIFNα-2b and ribavirin were surveyed. Low degree of fibrosis (measured by elastography, Fibroscan) or its absence was revealed in 77 patients while 67 patients had the significant fibrosis. Basal level of general cholesterol significantly did not differ in both groups. The level of general cholesterol was significantly above in convalescents despite of liver fibrosis degree. Patients with low fibrosis had significantly high level of general cholesterol in case of sustained viral response (SVR). Contrary in group of patients with the significant fibrosis the similar relations did not detected. Therefore, the baseline hypercholesterinemia is positive, irrespective of fibrosis degree, predictor of SVR.

Three follow-up single-stage standardized examinations for revealing of ischemic heart disease (IHD) were conducted among males at the age 50-59 with tuberculosis in 1972, 1998, 2011 years. The results of studies are conformed that prevalence of IHD among males with tuberculosis is not changed during this period and remained on relatively high level from 21.0-31.9%. Practically every 5th male with tuberculosis has clinical signs of IHD that could be considered as a support of necessity of joint simultaneous treatment of tuberculosis and IHD.

The article deals with the results of psychological and psychiatric analysis of age regression in patients with latent schizophrenia along with depersonalization, infantilism and social phobia. Clinical and social features of the phenomenon, internal psychological picture of the impairment of age self-consciousness (age regression) as a variant of auto-allopsychic depersonalization are discussed.

This article is dedicated to the problem of interaction between the nervous, the endocrine and immune systems based on the literature review and the author's data. Meanwhile, thymus is considered to be not only from the viewpoint of performance of the immune system, but also as the endocrine glandular making neuroimmunoendocrine interactions possible. Tactivine being a polypeptide thymus medicine impacts not only on the immune system but also displays detoxicating, mnemotropic and stress-protecting effects.

The work is based on the analysis of complex examination and treatment of 39 patients with chronic capitate pancreatitis. All patients with symptoms of obstructive jaundice underwent endoscopic intervention. In 10 (25.6%) cases pancreaticoduodenal resection (PDR) was performed, in 3 (7.7%) patients pancreaticojeunostomia (PJS) was imposed. Resection of the pancreatic head (RPH) was performed in 10 (25.6%) cases. Specific complications occurred only after the PDR and the PJS. The high level of mortality was registered after the PDR - 20%. Length of hospital stay was significantly lower after RPH. The quality of life in 28 (71.8%) patients in the late postoperative period was evaluated by the SF-36 Health Status Survey Questionnaire. The best results were registered in the patients who underwent RPH.

Surgical treatment of 53 patients with various pathologies of the soft tissues of the maxillofacial region using the radio wave surgery was performed. Clinical data indicate a high efficiency of radio wave surgery in the treatment of patients with soft tissue tumors of the face and oral cavity.

The Department of eye diseases and ophthalmology of Peoples' Friendship University of Russian has devised a method of the interlamellar circular, tunnel and sectoral keratoplasty for surgical correction of myopia and astigmatism of high degrees. In this article we have analyzed the results of our method. In total 140 operations were performed on 99 patients with follow-up period up to 13 years. 443 alloimplants were transplanted into the layers of the cornea and in 96.83% of cases (429 implants) transparent engraftment of the implants was achieved. Interlamellar keratoplasty is applied for correction of high myopia from 8.5 diopters up to 17.0 diopters; simple, complex myopic and mixed astigmatism from 3.5 diopters up to 9.5 diopters. The significant advantages of the interlamellar keratoplasty are: small trauma, lack of deep incisions of the cornea, the intact optical center of the cornea 6,0 mm, controllability of the refractive effect by replacing of alloimplants or their complete removal, if it is necessary, without any consequences for cornea.

Results of the research on reversal by Neostigmine and suggamadex of neuromuscular block, induced by amino steroid myo-relaxants during emergency surgical interventions. Importance of the neuromuscular monitoring during Anesthesia is discussed.

At the present time more dentists realize that to conduct only artistic restoration of the teeth, even by the most modern соmposition material, it is not yet enough. It is necessary not to have only an objective information on morphologies teeth, but also about functional condition of teeth gnathology apparatus We designed computer program on recovering the morphological teeth features, algorithm of action, describing the way of the reconstruction teeth соmposition materials acoording to modern computer program and reducing the time of modeling at increasing of efficiency and quality to aesthetic restoration. The teeth restoration by author's computer program may be done as by direct as well by indirect technology.

The article concerns about subperiosteal implantation on mandibula. This method is the alternative one in treatment of edentulous patients. Indications, stages of treatment and complications are introduced.

The changes in NIR spectra of substances resulting from the processes of natural aging were investigated. The method of discriminant analysis was used for statistical evaluation of differences between two groups of spectra - for initial and aged substances. The values obtained for the spectral range of each substance can limit the possible dispersion of the samples arisen during their aging.