Аbout typical responses of the damaged heart

V A Frolov; Фролов Виктор Алексеевич; D P Bilibin; Билибин Дмитрий Петрович; M L Blagonravov; Благонравов Михаил Львовович; G A Drozdova; Дроздова Галина Алексеевна; S M Chibisov; Чибисов Сергей Михайлович

Аbout typical responses of the damaged heart

Authors: Frolov VA¹, Bilibin DP¹, Blagonravov ML¹, Drozdova GA¹, Chibisov SM¹
Affiliations:
1. Peoples' Friendship University of Russia
Issue: No 3 (2011)
Pages: 8-11
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3258

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Abstract

On the basis of experimental research we described nine typical (nonspecific) responses of the damaged heart which are initially protective and adaptive but are able to have a pathogenetic character under some certain conditions. These typical responses are as follows: shortening of the effective refractory period of the myocardium, cardiomyocyte mitochondrion swelling, activation of lysosomal apparatus, initial intensification of lipolysis, hypertrophy of cardiac muscle, formation of collagen muffs around blood vessels due to intoxication, functional deafferentation of the heart, changes in the intensity of cardiomyocyte apoptosis, rearrangement of cardiac chronostructure. The represented results can be used as a basis to elaborate some new effective methods of prophilaxis and treatment of heart diseases caused by different etiological factors.

Keywords

heart, typical responses, apoptosis, biorhythms

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Vol 28, No 4 (2024): ONCOLOGY

Аbout typical responses of the damaged heart

Full Text

Abstract

Keywords

About the authors

V A Frolov

D P Bilibin

M L Blagonravov

G A Drozdova

S M Chibisov

References

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