Role of intercellular adhesion molecules in the development of the endometrial neoplasias

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Abstract

In article the processes of intercellular adhesion in unchanged proliferating endometrium, hyperplasia and adenocarcinoma are surveyed. Expression E-kadherin, β-katenin and claudin-1 at different stages of epithelial neoplastic transformation of endometrium by immunohistochemical method had been estimated. The role of key proteins Wnt-signaling pathway and Claudine-1 in the development of malignant transformation of glandular cells of endometrium was established.

About the authors

E E Shelokova

People's Friendship University of Russia

Email: babichenko@med.rudn.ru
Кафедра патологической анатомии; Российский университет дружбы народов; People's Friendship University of Russia

V A Kovyazin

People's Friendship University of Russia

Email: babichenko@med.rudn.ru
Кафедра патологической анатомии; Российский университет дружбы народов; People's Friendship University of Russia

I I Babichenko

People's Friendship University of Russia

Email: babichenko@med.rudn.ru
Кафедра патологической анатомии; Российский университет дружбы народов; People's Friendship University of Russia

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Copyright (c) 2011 Щелокова Е.Е., Ковязин В.А., Бабиченко И.И.

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