RUDN Journal of MedicineRUDN Journal of Medicine2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3258Аbout typical responses of the damaged heartFrolovV AКафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russiavictorfro@rambler.ruBilibinD PКафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russiavictorfro@rambler.ruBlagonravovM LКафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russiavictorfro@rambler.ruDrozdovaG AКафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russiavictorfro@rambler.ruChibisovS MКафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russiavictorfro@rambler.ruPeoples' Friendship University of Russia15032011381107092016Copyright © 2011,2011On the basis of experimental research we described nine typical (nonspecific) responses of the damaged heart which are initially protective and adaptive but are able to have a pathogenetic character under some certain conditions. These typical responses are as follows: shortening of the effective refractory period of the myocardium, cardiomyocyte mitochondrion swelling, activation of lysosomal apparatus, initial intensification of lipolysis, hypertrophy of cardiac muscle, formation of collagen muffs around blood vessels due to intoxication, functional deafferentation of the heart, changes in the intensity of cardiomyocyte apoptosis, rearrangement of cardiac chronostructure. The represented results can be used as a basis to elaborate some new effective methods of prophilaxis and treatment of heart diseases caused by different etiological factors.hearttypical responsesapoptosisbiorhythmsсердцетиповые реакцииапоптозбиоритмы