No 3 (2010)

In the present message preliminary results of the data of monitoring of parameters ECG dispersion map with the subsequent analysis of the characteristic of flicker-noise (1/f) are submitted. The given inspections of 47 patients have been included in research with a acuter coronary syndrom, surveyed in 1-3 day of disease (middle age - 54,5 ± 8,6 years) which are executed 91 monitoring by duration from 20 up to 90 minutes. At the visual analysis are revealed periodic low amplitude oscillations of values of an index of microalternations from a long wave from 2-5 till 6-15 minutes. Character and a degree of change of microalternations is new diagnostic area of attributes of ECG-diagnostics reflecting the electrophysiological status and «stock» compensatores resources of a myocardium It is shown, that there is a certain dependence of the characteristic 1/f from weight of current of disease, and flicker-noise - has prospect of use as a method possibiliti forecasting.

In this work the data of results of 259 patients observation with large intestine's polyps who had been treated in the Municipal clinical hospital № 2 in Nalchik during last 5 years are given. All mentioned patients underwent to endoscopic polypectomy. The patients were from 5 to 82 years old. All in all 535 neoplasms were removed. All removed neoplasms were extracted and sent for histological analysis except for 83 small neoplasms with the diameter less then 0,4 cm. These polyps are removed by electrocoagulation. The largest numbers of 452 extracted polyps were different types of adenomas. 28 of them were malignant. 12 patients with invasion of cancer cells into the submucosal layer were sent for surgical treatment. The other 16 patients had no invasion of cancer cells into the submucosal layer. Endoscopic polypectomy was evaluated as radical operation. There were no complications. All patients were discharged from the hospital in 2-7 days after operation. There were no recidives during 3-5 years.

The study of clinical effectiveness of synthetic somatostatin analogues in prophylaxis of bleeding from esophageal varices was conducted. There were 129 patients (mean age 45,2 ± 16,3) with previous or continuous bleeding from oesophageal varices included in the study, 65 of whom received synthetic somatostatin analogues (sandostatin and octreotide) therapy. Synthetic somatostatin analogues were administered as intravenous bolus injection in 100 μg dose, followed by continuous intravenous infusion at a rate of 25 μg/h for 2 days. From day 3, medication was given subcutaneously, 300 μg per day for another 3 days. The pressure in the portal system was measured with endoscopic tensometry in order to assess the effectiveness of somatostatin analogues. There was a tendency for portal pressure to decrease with a mean value being 33%. Synthetic somatostatin analogues are effective means of therapeutic haemostasis, preventing the recurrence of bleeding from oesophageal varices with haemostatic effect being above 85%.

The degree of tumor differentiation was a strong prognostic indicator for evaluation of disease-free survival of patients and to evaluate tumor-specific survival and mortality. In this 5-year disease-free survival in patients with highly differentiated (2-5 points) and poorly differentiated (7 points and 8-10 points) tumors differed in 1,5 times. Tumor-specific survival in patients with the IG > 8 was 66%, whereas with the IG < 8, this figure was 90%.

This work is about investigation of condition of intraocular pressure (IOP) after intravitreous injection of medicine avastine into eyeball with normal hydrodynamic. Injections were made for treatment of neovascular chorioretinal membrane plainly. The medicine was injected intravitreously in volume 0,05 ml with a special needle 30 gauge. IOP was measured by special surgical ophthalmotonometer of own construction. Measuring of IOP were made before injection, and also 30 seconds, 3 and 5 minutes after injection. Just after injection we discovered that IOP rose to 65 mm of hydrargerum. 5 minutes after IOP dropped down to 27 mm. Patients didn't have any pains or other unpleasant feelings in the eyeball although the IOP was very high at the moment.

Diprospan (betametason disodium phosphate plus betametason dipropionat) endonasal injection efficiency rating was carried out. Diprospan postoperative endonasal injection methodolody is described. In this research we compared nasal mucosa renewal in two patient groups. At first group (25 patients) we used endonasal Diprospan injection after operation, in second group (25 patients) - we didn't. Postoperative Diprospan endonasal injection makes mucosa recovery process faster.

The effect of plasmapheresis is studied at placentary insufficiency at 60 women after IVF with placenta isufficiency. The age of investigated women was from 26 to 42 years, average 34,6 ± 4,2 years. Among which 30 pregnant treated traditionally, 30 pregnant were treated by plasmapheresis and in combination with traditionally. Plasmapheresis (PA) performed discontinuous way. Eksfuziyu blood produced by cubital vein puncture into plastic bags «Gemafon 500» with anticoagulant-preservative glyugitsir. The amount of disposable eksfuzii of 450-500 ml of blood. In general, conducted 3 courses of treatment, at intervals of 3-4 days, under the dynamic performance of clinical and laboratory data. The result of our investigation showed that plasmapheresis and in combination with traditionally, permits to improve the indications of fetoplacental system and promotes favorable perinatal outcome and pregnancy, labors complication reduced. Researches have shown that plasmapheresis, considerably improves a fetus condition to what the, of USI, Doppler ultrasound and perinatal effects testifies. Improvement of maternal and perinatal outcomes is noted. Plasmapheresis is a prospective method of treatment allowing to, decrease medicinal loading on maternal and fetal organisms, to improve uterine- and feto-placental circulation, to lower an incidence of complications of pregnancy and delivery.

The correlation was investigated between the level of cell proliferation and the intensity of claudin-1 expression in oral Leukoplakia with different grade of cell neoplastic transformation (according to WHO classification 2005, - SIN - Squamous Intraepithelial Neoplasia) and in oral Squamous cell carcinoma. Claudin-1 expression and cell proliferation were assessed using immunohistochemistry in different epithelial layers of oral mucosa. The inverse correlation was revealed between the level of cell proliferation and the intensity of claudin-1 expression in oral Leukoplakia and oral Squamous cell carcinoma.

The cluster analysis of 12 metropolitan areas of Republic Bashkortostan by illnesses of urinogenital system (Ministry of Railways) is conducted. It is allocated three typological groups on the general disease of adult population of illnesses of Ministry of Railways.

The complex method of biomedical, clinical and mathematical techniques and calculations helped to work out an algorithm of functional tooth axis construction. The obtained data and mathematical models contribute to effective artificial occlusal tooth surface construction in such a way that the occlusal load vector was directed along the abutment tooth axis. These methods improve quality of orthopaedic treatment and ameliorate dental prostheses adaptation.

The task of our investigation was estimation the risk criterias for repeating myocardial infarction at patients with metabolic syndrome. Lipid and lipoprotein metabolism was affected at patients with repeating myocardial infarction and characterized by II b type on Fridricson dys lipidemia formation. The main diagnostically important parameter is both estimation of cholesterol in LDLP and oxidative modification of lipoproteins.

The present study is devoted to validation of method HPLC determination of zolpidem in biological liquids.

Determination of the number of platelets in HIV-infected people who applied in the Samara Regional Center for Prevention and Control of AIDS and infectious diseases. Thrombocytopenia was detected in 79%, severe in 23,1%. It was recorded at any stage of HIV infection and correlated with the level of CD4 lymphocytes. 45 patients was performed sternal puncture. Morphological evaluation of bone marrow showed changes in 87% of HIV-infected The most common violation was the low content or absence of megakaryocytes in bone marrow (72,5%).

Thrombocytopenia is a serious complication of HCV infection and often the first sign of this disease. The main role in the development of thrombocytopenia in HCV belongs to hypersplenism and activity of inflammatory process in the liver. Complex treatment of patients with secondary thrombocytopenia can, in some measure, to improve prognosis, reduce bleeding in patients with HCV.

It is proved that in the course of normal pregnancy parameters of regional gemodinamic have changed. We cannot use tipical of parameters of regional gemodinamic for state value condition during pregnancy. Parameters of regional gemodinamic were determined for normal pregnancy. The obtained data of an objective estimation of prognostic and diagnostic characteristics which is necessary for taking into account in planning of complex actions at all stages of medical observation.

The clinical observation of cases of atrial flutter in the newborn. Ineffective drug therapy (kordaron a saturation dose of 15 mg/kg/day and digoxin 0,03 mg/kg/day) has identified the need for electric pulse cardioversion.

Presentation of very rare clinical observation - perforation of the small intestines resulting to peritonitis as result of usage of focused ultrasound ablation method in the treatment of uterine myoma.

Among 224 examined children with tubulointerstitial nephritis (TIN). Mathematical modeling of the kidney function condition was carried out by the method of a SMA. The impairment of the kidney function in all patients occurred due to its tubular component that manifested itself in the impaired function of proximal and distal tubule. The SMA has confirmed the primary impairment of tubular functions. The designed weight factors and integral parameters reflected the tubular dysfunction.

This work is devoted possibilities to use the intraoperative photodynamic therapy in treatment of nоn-small lung cancer. Studied the problem of calculate light-doses necessary for inactivation tumor-cells in pleural cavities.

The article is devoted to the problems of the Medical professional liability insurance in Russia. Medical organizations or government are responsible for medical professional liability insurance.

The evaluation of ophthalmic diseases incidence and ocular appendicular apparatus, refraction impairment in urban population of the Novgorod region has been carried out. The tendencies of high ocular diseases incidence as well as spreading of myopia in the region, especially in children and teenagers have been considered.

There was investigated the possibility of using the service Web 2.0 while carrying out a distance course on pharmaceutical chemistry. The methodology of holding Internet seminar was described, the results were analysed.

Angiotensin II receptor blockers are highly effective and safe drugs that reduce the activity of RAAS. Valsartan is a quality, efficient antihypertensive drug with good tolerability. The effectiveness of valsartan is a combination of hemodynamic, neurohumoral, and metabolic effects, providing a positive outlook and steadfast nephroprotective. Combining a good tolerability, ease of use and lack of significant side effects, valsartan can rightly be considered the drug of first choice for treating such patients.

62 patients with arterial hypertension, stage II and III and ischemic heart disease, stenocardia II-III functional classes were divided into 4 groups. The 1st group received traditional therapy (TT): nitrates, β-adrenoblockers, ACE inhibitors, antiagregants, diuretics. The 2nd group obtained melaxen, the 3rd group - mebicar, the 4th group - eltacin on the background of TT. All patients registered arterial blood pressure and HR in the morning and evening. Correlation analysis was done between hemodynamic data and weather factors. These factors were obtained from server «Weather Russia» (meteoinfospace.ru). In TT there were revealed 64 correlations. Influence of temperature of air, atmosphere pressure, dew point on patients hemodynamics was statistically significant, especially on pulse in TT. Including melaxen decreased number of correlations till 35. Influence of temperature reduced. Dew points, direction and velocity of wind did not influence on hemodynamics. Mebicar produced 62 correlations between weather factors and hemodynamics. But influence of weather factors decreased on pulse substantionaly. Eltacin reduced number of correlations till 44. Relative numidity, cloudly were not influenced on hemodynamics.

The paper analyzes the controversial issue of electromagnetic radiation is extremely high frequency range in clinical practice. The authors draw on their fifteen years of experience with this type of radiation, emphasize the outstanding issues concerning the parameters and dosage effects of EHF EMR, which are determined by the capabilities of adaptive-compensatory reactions of the organism.