The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthsis velocity in test-systems from tissues with high proliferation

S P Siatkin; Сяткин Сергей Павлович; Т Т Berezov; Березов Т Т; T V Fedoronchuk; Федорончук Т В; N Yа Gridina; Гридина Н Я; E A Neborakh; Неборак Е А; N A Shevkhun; Шевкун Н А; N A Sokueva; Сокуева Н А; E V Ustinova; Устинова Е В; R I Sokuev; Сокуев Р И

The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthsis velocity in test-systems from tissues with high proliferation

Authors: Siatkin SP¹, Berezov ТТ¹, Fedoronchuk TV¹, Gridina NY.¹, Neborakh EA¹, Shevkhun NA¹, Sokueva NA¹, Ustinova EV¹, Sokuev RI¹
Affiliations:
1. Russian Peoples' Friendship University
Issue: No 3 (2010)
Pages: 9-14
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3500

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Abstract

The aliphatic (amino)- and (oxy)-derivatives of polyamines effect on the rate of polyamines (Putrescine, Spermidine and Spermine) synthesis in cell-free test-systems from rat's regenerating liver and Hepatoma tissues was examined. The common known inhibitors of polyamines synthesis were also used for the analysis. The research data confirm that cell-free model systems function adequately to applied tests. The effectiveness of anti-proliferate action of chemical compounds was valued by the inhibition degree of Putrescine and polyamines synthesis. In addition, the coefficient of ratio Spermidine (moles)/ Spermine (moles) and the value of total Polyamines pool after 1 h of test-systems incubation with chemical compound were calculated. From the tested compounds 1-aminooxy-3-aminopropan (I), S-(5'-desoxyadenosile)-S-methyl-β-thioethyl-hydroxylamine (IV) and ethylenediamine (V) did satisfied the requirements to a considerable degree.

Keywords

polyamines, Putrescine, Spermidine, Spermine, oxidative deamination, Difluoromethylornithine, Ornithine decarboxylase

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Vol 29, No 1 (2025)

The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthsis velocity in test-systems from tissues with high proliferation

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Abstract

Keywords

About the authors

S P Siatkin

Т Т Berezov

T V Fedoronchuk

N Yа Gridina

E A Neborakh

N A Shevkhun

N A Sokueva

E V Ustinova

R I Sokuev

References

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