No 4 (2008)

The soft medicinal forms antiviral and antimicrobic action (a cream and liniment of giporamin and evkalimin 0,5% of concentration) had been elaborated. Research of chronic toxicity of a giporamin cream and evkalimin liniment is lead on rabbits of breed Chinchilla with initial weight of a body 3,2-3,7 kg. Medicinal forms of evkalimin and giporamin put on depilate a site of a leather of a back of rabbits in the size 5 × 5 sm in quantity 2,0 gr. on an animal once in day within 8 weeks. Rabbits of control group received applications placebo a cream and liniment. In chronic experiment during longitudinal skin applications the creme and the liniment are good transferred by animals and don't provocate skin irritation. The elaborated drug forms do also not have ivitant action to the eye mucous. Toxicological research, general toxicological and local irritation action, soft medicinal forms, a cream, a liniment, phytopreparations antimicrobic and anti-inflammatory action, giporamin, evkalimin.

The anatomical structure of parts of the herb of the Hypericum perforatum L., which are absent in the normative documentation, is studied. The influence of solutions of urea and CoSO4 upon accumulation of the sum of flavonoids in the raw material with foliar feeding is examined. Leaves and flowers in the structure of the herb of the Hypericum perforatum are characterized by maximum accumulation of the sum of flavonoids at converting into rutin. Its maintenance in 3-4 times above, than in stalks. For increase of accumulation of the given connections both in leaves and flowers, and in stalks most rational was processing of plants of 2% solution of CO(NH2)2 and solutions CoSO4 in a phase of budding. It has allowed to increase the maintenance of the sum of flavonoids in leaves and flowers on the average by 1,5%, in stalks - on 0,9% in comparison with the control. The general gathering of the sum of flavonoids in leaves and flowers increased in 2,3 times, in stalks - in 9,3 times.

Principles and approaches to a choice by the Russian pharmaceutical companies of the markets for the international activity are considered. Process of a choice of the foreign market includes four stages: 1) factor analysises, 2) determining of criteria of an estimation and actually an estimation by criteria, 3) choice of the most long-range market and an estimation of its potential, 4) estimation of risk.

The article is devoted to problems of organizational designing. Data about organizational structures of pharmacies of Moscow, received by means of questioning are reflected in it. In this article are presented - frequency of occurrence of various divisions of a drugstore, the characteristic of the personnel, problems of coordination of activity on the basis of data about interchangeability of employees of a pharmacy are revealed.

The following have been established through marketing analyses: 1) the share of the product mix of the given group of medications in pharmacy organizations; 3) the basic target categories of physicians who prescribe medications of this group; 4) basic regimens of treatment used as therapy for acid-dependent diseases of the stomach in the group of patients with gastritis and ulcer disease of the stomach; 5) factors that have an effect on physician prescribing of antacid and anti-ulcer medications for hospital patients and outpatients; 6) preferences and factors that shape the demand of end users for drugs of the given group; and 7) a portrait of the consumer of antacid and anti-ulcer medications.

The article concerns some ecological aspects of therapeutic features of speleotherapy. The objective of our study was to investigate the therapeutic activity of speleotherapy for respiratory disorders according to it's ecological aspects. The results of including speleotherapy into the curative and prophylactic complex in the central-chernozyom region showed the decrease of incidence of respiratory pathology in people, who underwent the course of speleotherapy. The obtained data indicated, that speleotherapy was supposed to be used as a component of prophylactics complex in treatment for broncho-respiratory complex.

Antiaggregation activity of first synthesized benzimidazole and xantine derivatives has been studied. Differences in impact of the compounds on blood coagulability have been shown. We have synthesized L-65, on active compound, that suppresses platelet aggregation and has an acetylsalicylate acid-like effect. The results obtained concerning the screening of bioactive substances are promising.

To localize tubercular infection it's necessary to determine tubercular cases before considerable bacterioexcretion and disease processing into chronic forms. Fibrose cavitary disease - is a chronic disease proceeding intermittently during a long period with intervals of remissions.

Diagnostics and treatment of cirrhoses of a hepar are standardized, however in the expert plan at carrying out departmental, non-departmental and forensic medical examinations for the decision of questions on quality and character of the medical care, this is nosology represents the big complexities. It is difficult enough to define positive consequences from rendering assistance, to connect consequences with defects of treatment, whether to define are negative consequences result of treatment or a natural current of process. In work the technology of examination of quality and character of medical aid on the basis of allocation of the defects leading to negative consequences from rendering of medical care is offered. The defects defining negative consequences, are allocated by means of statistical criteria of Kraskel-Uolles and the Mann-Whithney, the importance of each defect was defined on methods of Vald and Kulbak. Set of defects has allowed to allocate such indicator as saved up informative a case, as the arithmetic sum informative the revealed defects. The method of binary logistical regress reveals dependence between indicators saved up informative and consequences of rendering of medical care. The offered technology provides objectivity of an expert estimation and repeatability of examination with experts of other establishments.

The management abilities of the adaptive process at chronic cerebral ischemia is the object of this study. The influence to a level of adaptive abilities at the different stages of chronic cerebral ischemia of complex natural adaptogen and modulate peptide. Natural adaptogen stimulates stress-action systems and realizes the mechanisms of the longtime adaptation. Modulate peptide stimulates stress-limited system, that protects human from exhaustion of the adaptive reserve. The using of stressmodulate therapy is advisable way of therapy.

The retrospective medical charts review of 1146 patients with type II diabetes mellitus was done in outpatients clinics. The minimal attention was observed towards main risk factors, as well of the frequency of diagnostic procedures was insufficient for adequate control of diabetes mellitus and cardiovascular disease. The prognosis of diabetes mellitus could be improved by the aggressive treatment and correction of cardiovascular risk factors implemented by doctors of different specialties.