Toxicological studying of soft medicinal forms antiviral and antimicrobic actio

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Abstract

The soft medicinal forms antiviral and antimicrobic action (a cream and liniment of giporamin and evkalimin 0,5% of concentration) had been elaborated. Research of chronic toxicity of a giporamin cream and evkalimin liniment is lead on rabbits of breed Chinchilla with initial weight of a body 3,2-3,7 kg. Medicinal forms of evkalimin and giporamin put on depilate a site of a leather of a back of rabbits in the size 5 × 5 sm in quantity 2,0 gr. on an animal once in day within 8 weeks. Rabbits of control group received applications placebo a cream and liniment.
In chronic experiment during longitudinal skin applications the creme and the liniment are good transferred by animals and don't provocate skin irritation. The elaborated drug forms do also not have ivitant action to the eye mucous.
Toxicological research, general toxicological and local irritation action, soft medicinal forms, a cream, a liniment, phytopreparations antimicrobic and anti-inflammatory action, giporamin, evkalimin.

About the authors

O A Semkina

Peoples' Friendship University of Russia

Кафедра общей фармацевтической и биомедицинской технологииМедицинский факультет; Российский университет дружбы народов; Peoples' Friendship University of Russia

M A Dzhavakhian

Russian Institute of Drugs and Aromatic Plants VILAR

Russian Institute of Drugs and Aromatic Plants VILAR

L V Krepkova

Russian Institute of Drugs and Aromatic Plants VILAR

Russian Institute of Drugs and Aromatic Plants VILAR

V V Bortnikova

Russian Institute of Drugs and Aromatic Plants VILAR

Russian Institute of Drugs and Aromatic Plants VILAR

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Copyright (c) 2008 Сёмкина О.А., Джавахян М.А., Крепкова Л.В., Бортникова В.В.

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