No 1 (2014)

The article presents the physiological justification of individual prenosological control, which aims to assess the dynamic adaptation risks to predict adaptation disorders. Disease development is preceded at first by the prenosological and then by premorbid conditions. Definitely, these states in healthy people are the object of prenosological control. The heart rate variability analysis was used, which allows using mathematical models and probabilistic approach to estimate the probabilities of different functional states: physiological norm, prenosological and premorbid conditions and adaptation breakdowns. Four groups of individuals with low, medium, high and very high risk of disadaptation were classified at investigation of 120 healthy subjects under long-term medical and environmental research project “Mars-500”. Representative examples of the functional state of annual dynamics show that at very high risk of adaptation of practically healthy people in autumn and spring there are signs of premorbid state. Results of individual prenosological control in a group of volunteers - scientific workers, have shown that even normal daily loads cause a transition to prenosological state. Presented data confirm the viability of the further development of individual prenosological control systems.

The paper presents an analysis of effectiveness of antiviral therapy for chronic hepatitis C in HIV-infected patients, factors affecting the achievement of sustained virologic response are revealed.

This report presents preliminary results of the analysis of the circadian monitoring factors of dispersion mapping (DM). Analyzed daily ECG monitoring in healthy individuals in a free life activity (I group), the data obtained during the research program "Mars-500" in 6 healthy men (2 group), in patients with hypertension (3 group) and IHD with episode of ventricular arrhythmia I-II class on Launu (4 group). For analysis areas by duration in 15-20 minutes from each hour «were cut". Study of the circadian factors of ECG-signal microalternations is a new diagnostic approach to the analysis of electrophisiological status and diagnostic test of the revealing of the myocardium lesions. DM method can be used to obtain new data on electrophysiological features of the myocardium during the day and the diagnosis of myocardium electrical heterogenicity.

The article describes nonspecific prevention methods of postoperative complications after treatment of hip and tibial fractures at the patients of old age, associated with development of fat embolism, thromboembolism and pulmonary disorders. The most effective of them are early and strong fixation of fragments of the broken bone, activization of the patient and early prevention of pathological changes in blood circulation and breath systems. A number of the devices providing qualitative preventive measures and giving differently directed effect is offered.

The aim of this study was to determine of TRF1, MMP-7, FLT-1, KDR and VEGF mRNA expression levels obtained from prostate biopsies samples of patients with benign prostatic hyperplasia, prostate cancer and healthy men without prostate pathology. It was demonstrated that detection of TRF1, FLT-1, KDR and MMP-7 expression levels correlations and TRF1/MMP-7 index was criteria of different way for different prostate neoplasm diagnostics.

By analyzing survey data, found that in the subjective assessment of the quality and effectiveness of specialized ENT care to patients with diseases of the nose and paranasal sinuses, the majority of respondents fully satisfied with assistance provided. Revealed that the most highly they estimate medical staff and less - organizing medical care.

Dengue fever (DF) is a common cause of arboviral infections in South America, belonging to the genus Flavivirus. Only in Fortaleza, the 5 th most populated city in Brazil, in the year of 2011 over 110 cases of dengue fever by day were being registered [3]. DF is only rarely considered as a cause of acute liver failure [4], while this particular case involves three different systems, being the reason why it called our attention. 50 year old, male, conscious, presents to São José Hospital of Infectious Diseases with classic dengue fever symptoms, being the day of his admission the 9 th since the first symptoms erupted. Other causes for acute hepatic failure like acute viral hepatitis, leptospirosis, malaria, Reyes syndrome were ruled out, had the patient already been tested for dengue IgM in a local hospital. Complained of a pain in his abdomen, simple thorax radiography showed an enlarged cardiac area. His ECG reinforced the cardiac enzymes’ results, showing a clear alteration in ventricular repolarization. Patient progressed with shock, cardiac insufficiency and ischemic hepatitis. With treatment for the multiple conditions he made a significant clinical and biochemical improvement. He was discharged after 33 days of hospital stay.