The mechanism of immunosuppression in patients with brain glioma

V A Frolov; Фролов Виктор Алексеевич; S P Syatkin; Сяткин Сергей Павлович; N Ya Gridina; Гридина Нина Яковлевна; N G Draguntsova; Драгунцова Наталья Геннадиевна; O I Veselova; Веселова Ольга Игоревна; V P Chunikhin; Чунихин Александр Юрьевич; A Yu Maslov; Маслов Владимир Петрович; Yu V Ushenin; Ушенин Юрий Валентинович

The mechanism of immunosuppression in patients with brain glioma

Authors: Frolov VA¹, Syatkin SP¹, Gridina NY.², Draguntsova NG², Veselova OI², Chunikhin VP³, Maslov AY.⁴, Ushenin Y.V⁴
Affiliations:
1. Peoples’ Friendship University of Russia
2. State Institution “Institute of Neurosurgery of the Ukrainian NAMS”
3. Institute of Biochemistry n.a. A.V. Palladin of the Ukrainian NAS
4. Lashkarev Institute of semiconducter physics of the Ukrainian NAS
Issue: No 1 (2014)
Pages: 11-17
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3184

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Abstract

The activity of diamineoxydase and polyamineoxydase which were synthesized by blood cells in the culture medium during the transformation of lymphocytes in the blasts when exposed to various dilutions of phytohemagglutinin have been determined in patients with cerebral gliomas of different degree of malignancy. Under these conditions, the degree of aggregation of blood cells was determined by new highly sensitive method of surface plasmon resonance. Increased activity of diamineoxydase and polyamineoxydase in spinal hernias and decreased activity of these enzymes in malignant gliomas has been found. The regulatory role of these enzymes in the processes of lymphocyte proliferative activity in neurosurgical pathology, including brain gliomas of different degree of malignancy, is suggested.

Keywords

Polyamines, Diamine oxydase, polyamineoxydase, brain malignant gliomas, inflammation, lymphocytes

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

The mechanism of immunosuppression in patients with brain glioma

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Abstract

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About the authors

V A Frolov

S P Syatkin

N Ya Gridina

N G Draguntsova

O I Veselova

V P Chunikhin

A Yu Maslov

Yu V Ushenin

References

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