No 3 (2014)

Heat balance of homoiothermic animals allows significant physiological deviation from the preset settings “set point” centers of hypothalamic regulation despite of the difficult-organised system of its maintenance. In other words, the warm-blooded organism normally has thermal heterogeneity. With the development of pathological states, accompanied by fever and increasing of body temperature, temperature heterogeneity is changing. The origin of these changes is rarely the subject of special studies, because the algorithm of the diagnosis is usually considered as an assessment of basal temperature in one department thermal “center” only. However, the increase of the temperature of the brain in patients with cerebral accidents does not always correspond to the changes in basal body temperature, which can lead to the underestimation of local hyperthermia of the brain in traditional thermomonitoring. Anatomical, functional and metabolic features create the special conditions of maintenance of the cerebral temperature balance in comparison with the conditions of regulation of temperature of the heat “center”.

Work is devoted to the most difficult poisoning with complications in the form of rhythm and conduction disorders. 128 patients with acute poisoning with cardiotoxic substances, admitted to the toxicological center, were investigated. The first group included 52 patients who took medications suppressing the automaticity and conduction of the heart and leading to the most severe disturbances of rhythm and conduction: cardiac glycosides - 8, b-adrenoblocators - 8, verapamil - 6 and clonidine - 30 patients. The second group of 23 patients with the poisoning by the water and spirit tincture of hellebore providing a reflex effect on the chemoreceptors and cause more light violations of rhythm and conduction disturbances. The third group of 25 patients with trycyclyc antidepressants (TADs) having a cholynolytyc effect and inducing stimulating of automatism and excitability of the heart. The fourth group (28 patients) included phosphororganic insecticides (PHOI) with antycholynesteraze action suppressing the heart automatism and conductivity. Violations of rhythm and conductivity of the heart in case of poisoning with cardiotoxic substances often manifested in the form of bradyarrhythmias. The exception is a tricyclic antidepressant poisoning. In somatogenic phase of acute poisoning with cardiotoxic substances with a favorable outcome rhythm and cardiac conduction disturbances disappeared, indicating their functional character.

Studied clinical features of paranoid schizophrenia in patients with diabetes mellitus, since the clinical picture and the mutual impact of these diseases on each other have not been studied sufficiently and now there is a need for optimization of methods of pharmacotherapy and development of a new model of medical care to this group of patients. This problem is especially actual taking into account the wide use of atypical antipsychotics, which may contribute to the development of diabetes, in addition, according to the literature, schizophrenia often (8,8-18%) combined with diabetes.

Benign prostatic hyperplasia is the most frequent disease among middle and old aged men. The purpose of our study is to assess the efficiency of diagnosis of benign prostatic hyperplasia (BPH) without complications and with urine retention. Transrectal sonography was performed in 77 patients with BPH. The estimation of blood flow in patients of main group performed with transrectal ultrasound with Doppler. The speed of blood flow measured in subcapsular and paraurethral arteries with estimation of diameter and speed of vein drain in the paraprostatic veins. Transrectal sonography showed the changes in the prostatic blood-flow especially in case of urine retention. Transrectal ultrsonography playys an important role in the evaluation of the prostatic blood-flow.

Presents the results of the use of Bivalirudin in actual practice in patients with acute coronary syndrome during percutaneous coronary intervention (PCI). Demonstrated high efficiency of Bivalirudin in the amount of bleeding occurring in the postoperative period and adverse cardiovascular complications.

The work is devoted to reproductive losses of children born with body weight up to 2500 g according to WHO criteria for 2012-2013. Changes in registration of births promoted growth of preterm infants that led to the increase in their contribution to the volume of reproductive losses.

Purpose: to develop preventive measures and reasonable therapy of pathological processes in the cervix uteri based on detection of methylation of tumor suppressor genes and groups at high-risk of cancer among patients of reproductive age with benign and premalignant cervical processes. Effectiveness of complex pathogenetic treatment of the cervix uteri has been evaluated in 127 women of reproductive age with benign and premalignant cervical processes before and after the combined treatment with a pharmaceutical composition containing active substance epigallocatechin-3-gallate (EGCG). Shown that pharmaceutical composition containing EGCG contributes demethylation of the tumor suppressor genes that confirm powerful oncoprotector action in treating precancerous lesions. One year after the complex combined therapy (including surgery) with pharmaceutical composition containing EGCG, recurrent cervical pathological processes have not been detected in patients with benign lesions, CIN I and CIN II.

The article presents the results of an anonymous survey of 850 citizens of the Orenburg region wishing to volunteer for military service under contract in the Armed Forces of Russia. Found that persons aged 19-25 years (72%) who have graduated from specialized secondary schools or 11 classes of secondary schools prevailed. At the time of entering on military service under the contract 78,6% of respondents were unemployed and only 47,5% of respondents answered positively to the question “the military service under the contract - it’s my calling”.