RUDN Journal of MedicineRUDN Journal of Medicine2313-02452313-0261Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)3132Research ArticleProperties of the left ventricular myocardium structure in experimental acute diphtheria intoxicationKorshunovaA JuDepartment of General Pathology and Pathological Physiologyannakorsh@gmail.comBlagonravovM LDepartment of General Pathology and Pathological Physiologyblagonravov_ml@pfur.ruFrolovV ADepartment of General Pathology and Pathological Physiologyvictorfro@rambler.ruAzovaM MDepartment of Biology and General Geneticsazovam@mail.ruPeoples’ Friendship University of Russia150320143212507092016Copyright © 2014,2014Diphtheria is considered to be vaccine-preventable disease due to organized immunization programmes. However there are still endemic regions of diphtheria, whence reports of mortal cases are coming. Most of deaths are caused by cardiotoxic effect of diphtheria toxin. Structural changes of left ventricular myocardium were investigated on a model of acute diffuse diphtheria intoxication. It was found that the most significant inflammatory signs manifest on the 5 th day of the experiment which is confirmed by profound infiltrative-degenerative changes of the myocardium.myocardiumleft ventriclediphtheria intoxicationмиокардлевый желудочекдифтерийная интоксикация