No 2 (2012)


Diet and lifestyle guidelines for prevention of cardiovascular disease and diabetes amog elderly persons

Singh R.B., Chibisov S.M., Frolov V.A., Shastun S.A.


Elderly subjects have unique nutrient needs with revised recommended dietary reference intakes based on age, sex, ethnicity and special vulnerability to compromised nutrient status. The food intake tends to decrease with advancing age due to decreased physical activity and metabolic rate. However vitamin; A, E, C, B vitamins and beta-carotine and minerals magnesium, calcium, selenium, chromium, zinc and copper as well as w-3 fatty acids needs either remain constant or increase. Omega-3 fatty acid, calcium, vitamin D and magnesium and antioxidant intakes are inversely associated with ageing and other complications like cardiovascular diseases, diabetes and dementia as well as cancers. It is pertinent to advise to eat 400 g/day of fruits, vegetables and nuts and another 400 g/day of whole grains in conjunction with 25-40 g/day of canola oil or mustered oil, depending upon energy requirement, for prevention of cardiovascular disease and type 2 diabetes mellitus.
RUDN Journal of Medicine. 2012;(2):7-12
pages 7-12 views

Visualization of amplitude-phase relationships in entrainment processes

Katinas G.S., Cornélissen G., Schwartzkopff O., Halberg F., Chibisov S.M., Shastun S.A., Dvornikov V.E., Frolov V.A.


In the present research the visualization of amplitude-phase relationships in entrainment processes is based on the expression serial time sections [3] allow tracing the behavior of different parameters of any rhythmical component of spectrum during a time which includes spans before, during and after any synchronizing (desynchronizing) event. There is a simple and noninvasive method for acquiring information on the visualization of amplitude-phase relationships. The method used the mathematical and graphic analysis simultaneously visualization the dynamics of amplitude, its statistical significance and acrophase in entrainment processes, the three modifications of serial sections was elaborated: procedure of adding logarithms of P-values-matrices, plotting 2D image and 3D image. As examples for illustration serial section method, automatic measurements of blood pressure (BP), both systolic (S) and diastolic (D), and heart rate (HR) were used. Five flights from Minneapolis (USA) to Saint-Petersburg (Russia) crossing 9 time zones and 4 flights in the opposite direction were performed during that time (during the second return flight, no measurements were taken). The simultaneous drop in amplitude and the rapid shift in acrophase associated with West-to-East flights, and more gradual changes for East-to-the-West flights led to the hypothesis that the rapid entrainment is performed by collapse of the rhythm at a singularity time point. Application of the present method has allowed the authors to carry out visualised dynamic chronobiological the control parameters of cardiovascular system. The method has higher diagnostic value in comparison with well-known procedures of an estimation of chronomedicine.
RUDN Journal of Medicine. 2012;(2):13-22
pages 13-22 views

The polymorphism c677t of the gene MTHFR correlates with the complications of the coronary heart disease and arterial hypertension for the patients with dislipidaemia

Myandina G.I., Kasapova E.N., Zotova T.U., Frolov V.A.


The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments.
RUDN Journal of Medicine. 2012;(2):23-27
pages 23-27 views

Air ions and human environment

Pleteneva T.V., Maksimova T.V., Khodorovich N.A., Syroeshkin A.V.


Conformity to hygienic air ion formula of working offices, classrooms and chemistry laboratory in which the work with volatile organic solvents are conducted, as well as to a city apartment and a country house is investigated. Concentration of air ions was measured using the counter «Sapphire 3М». Parameters of the air ionization: concentration of ions of both charges (N and N-, ions/cm3) and unipolarity coefficient (K = N/N-) were evaluated. The quantity of air ions did not correspond to sanitary and hygienic standards in all areas except of a country house. Additional artificial air ionization and ventilation in classrooms and chemistry laboratories offered to use.
RUDN Journal of Medicine. 2012;(2):28-34
pages 28-34 views

Opportunistic infections: algorithms of the diagnostic and of evaluation of predisposition to emerge

Volina E.G.


Hereby are provided the algorithms of evaluation of predisposition to emerge and ethyological diagnostic of the opportunistic infections.
RUDN Journal of Medicine. 2012;(2):35-39
pages 35-39 views

Blood preserving technology in cardiac surgery

Tarichko Y.V., Dobrovolsky S.R., Veretnik G.I., Dandarova Z.B., Faybuschevich A.G., Romaschov F.N.


According to the program of blooding surgery 297 patients were operated with coronary heart disease, acquired and congenital cardiac diseases and others. The introduction of principles of bloodless surgery is favoured by not only risk from donor transfusion, but also by the results of the reserchers dealing with the body's adaptation to acute anemia. The present study was undertaken to make a scientific-and-practical assessment of actual own blood funds and their introduction in order to decrease or refuse to use donor blood at cardiac surgery under extracorporeal circulation. Own blood saving methods, such as acute normovolemic hemodilution, washed autoerythrocytic reinfusion, autoplasma reinfusion, become affective in reducing hemorrhage after extracorporeal circulation. This method is safe, simple in organization, and permitted to avoid allogeneic blood transfusion and its complications.
RUDN Journal of Medicine. 2012;(2):40-44
pages 40-44 views

Functional activity of platelets in allotransplantation of the hypothalamic-pituitary-gonadal axis

Kirpatovskiy I.D., Smirnova E.D., Kaitova Z.S.


The research representsthe investigation and implementation in the clinic immunosupressive therapy after allotransplantation of the hypothalamic-pituitary-gonadal axis. Patients received immunosupressive therapy (prednisolone, choriogonin, heparin, a local X-ray irradiation) after organ transplantation. Immunosuppressants were cancelled stepwise. The results showed that the basical immunosupressive therapy provides stable acceptance of allotransplants of the hypothalamic-pituitary-gonadal axis.
RUDN Journal of Medicine. 2012;(2):45-48
pages 45-48 views

The microsurgical formation of lymphnode-veinose anastomoses at lymphatic edema of extremities

Kirpatovskiy I.D., Smirnova E.D., Titarov D.L.


The original method using for anastomosis formation between lymphatic node's subcapsular sinus and nearlying subcutaneous vein allows to cure or to achieve constant prevention of soft tissue lymphatic edema progress at extremities.
RUDN Journal of Medicine. 2012;(2):49-51
pages 49-51 views

Permanent cardiostimulation ih the general surgery

Tarichko Y.V., Baranovich V.Y., Dobrovol'sky S.R., Maximkin D.A., Veretnik G.I., Faybuschevich A.G., Dandarova Z.B., Romaschov F.N.


Paper is devoted to the safety rules during surgical interventions on patients with permanent pacemaker. Data of 123 operated patients with intraoperative pacemaker instability were analyzed; possible causes of these complications were discussed. The use of monopolar electrocoagulation proved to be the most frequent cause of pacemaker failure. Strong correlation between rhythm failure and duration of the single electrocautery exposure was revealed.
RUDN Journal of Medicine. 2012;(2):52-55
pages 52-55 views

Discoid meniscus

Batygin G.G.


In 1934 Finder announced about 25 cases of discoid external intraarticuler cartilages of genus. Normally the menisci have a mesodermal development and differentiate from mesenchimal cells. In the aetiology of discoid meniscus are presented several theories. Discoid meniscus can be a disturbtion purpose for the patient. The frequency of discoid meniscus if high in the Asia. In some cases needs the operative treatment of discoid meniscus.
RUDN Journal of Medicine. 2012;(2):56-60
pages 56-60 views

The impact of perioperative oral supplementation with immunomodulating diets on postoperative period in patients with major gastrointestinal surgery

Panova N.G., Shestopalov А.Е., Butrov А.V., Stets V.V., Polovnikov S.G., Ziryanov V.A.


Perioperative administration is an important period for nutritional status management. The aim of the study was to assess the impact of perioperative oral immunomodulating diets supplementation in 41 patients after elective major gastrointestinal surgery. Perioperative oral immunomodulating diets supplementation with glutamine and Ω-3 fatty acids during 5 days before surgery enchanced the immune status of the patients,reduced the duration of ICU and hospital stay, and decreased the incidence of postoperative infectious complications.
RUDN Journal of Medicine. 2012;(2):61-68
pages 61-68 views

Perioperative prevention of cardiovascular complications in patients with atherosclerotic lesions of the infrarenal aorta

Neimark M.I., Berezhnoi D.A., Kiselyov R.V.


The study involved 237 patients aged 54 to 69 years who underwent aorto-bifemoral bypass surgery due to the atherosclerosis of aorta and its branches. Depending on a method of the anesthesia, patients were divided into 3 groups: in 1st group NLA was used, in the 2nd - epidural anesthesia at ThXII-LI with mechanical ventilation and in the 3rd - thoracic epidural anesthesia at ThX-ThXI with mechanical ventilation. The patient groups were representative. The most high and stable rates of coronary blood flow and central hemodynamics were in patients with thoracic epidural anesthesia (ThX-ThXI) with mechanical ventilation, due to the small doses of local anesthetic combined with a narcotic analgesic. Blockade of the sympathetic trunk has provided the most high and stable parameters of coronary flow, stroke output index and cardiac output fraction compared with other groups of patients.
RUDN Journal of Medicine. 2012;(2):69-75
pages 69-75 views

Influence of COPD on the development of renal disease and identification of nature of kidney with specific markers

Trishina V.V., Bychkova L.V., Fedorenko M.G., Politidis R.R., Bilibina S.V., Amanboev A.Z.


It is still not quite clear how chronic obstructive pulmonary disease (COPD) affects the urinary system. The investigation of renal disease as systemic manifestation of COPD is still relevant.
RUDN Journal of Medicine. 2012;(2):76-80
pages 76-80 views

Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C

Nikolaeva L.I., Sамоkhvalov Е.I., Al'khovskiy S.V., Kolotvin A.V., Samokhodskaya L.М., Makashova V.V., Тokmalaev A.К.


Aim: to determine influence of genetic polymorphisms of hepatitis C virus and single nucleotide polymorphisms (SNPs) of patients with chronic hepatitis C on achieving sustained virological response (SVR) to antiviral therapy. One hundred blood samples of eastern-Slavonic patients with different response to the therapy were analyzed. It was determined, that among SNPs of 7 human genes only allelic variants of IL-1β, IL-28B, TGF-β1 and viral genotypes can influence on probability to achieve SVR.
RUDN Journal of Medicine. 2012;(2):81-88
pages 81-88 views

Assessment of endothelial function in children and adolescents with arterial hypertension by high-resolution ultrasound

Petrenko T.E.


In 72 children and adolescents with arterial hypertension I-II st. after reactive hyperemia using high resolution ultrasound lower rates of increase in the diameter of the brachial artery (BA) and peak blood flow velocity were detected compared to the normotensive control group of children that may be regarded as the depletion of vasodilatation. In children and adolescents with hypertension during occlusion test а more significant decrease of the diameter of BA was revealed, indicating the functional arteriolar hypertonicity, as well as the possible remodeling of arterial vessels. These results should be interpreted as increased tone of BA in children and adolescents with hypertension.
RUDN Journal of Medicine. 2012;(2):89-93
pages 89-93 views

AGE-specificity in acute pain syndrome measurement in otorhinolaryngology

Popadyuk V.I., Kastyro I.V., Chuluunbaatar S., Drozdova G.A.


In this study, 133 patients were divided by age into three groups. First group: from 17 to 29 years old; second group: from 30 to 49 years old; and third group: from 50 to 75 years old. Pain intensity of patients was measured by means of a Visual Analogue Scale (VAS), of a Numeric Rating Scale (NRS) and of a Verbal Lightning Scale (LS). All three scales could be used in measurement of pain of patients of the first group whereas NRS is preferable for the second group and LS - for the third group.
RUDN Journal of Medicine. 2012;(2):94-99
pages 94-99 views

Clinical efficacy and safety of Ceraxon® for treatment of primary open-angle glaucoma

Frolov M.A., Gonchar P.A., Barashkov V.I., Kumar V., Morozova N.S., Frolov A.M., Kazakova K.A.


35 patients with primary open-angle glaucoma (POAG) with unstabilized clinical course and normalized intraocular pressure were treated. All patients were divided into subgroups: 8 patients - with the Ist stage of POAG, 12 - with the IInd and 15 with stage III-IV. Patients were examined with clinical-ophthalmologic and instrumental methods. After the treatment by CERAXON® an improvement of visual functions were noted, accompanied by significant positive dynamics of perimetric and morphometric characteristics: average light sensitivity and defect, dispersion, average thickness of retinal nerve fiber layer. During the treatment by CERAXON® there wasn't any case of side effects, demanding drug withdrawal or change of therapeutic regimen.
RUDN Journal of Medicine. 2012;(2):100-103
pages 100-103 views

The influence of efferent-quantum methods on the immunity in patients with psoriasis

Baityakov V.V., Filimonkova N.N.


Aim: to study the influence of plasmapheresis, ultraviolet blood irradiation and their combination on the immunity indices. 142 patients with the progressive stage of extensive psoriasis from the age of 18 to 67 have been investigated. Indices of phagocytosis, cellular and humoral immunity have been studied in dynamics. Elevated levels of immunoglobulin M and A, circulating immune complexes, an imbalance of T-cell immunity as well as increasing neutrophil activity level of protection were revealed. The inclusion of the efferent-quantum methods in the complex treatment of psoriasis contributes to the normalization of T-lymphocyte subpopulations and the absorptive activity of neutrophils, reducing the CEC, immunoglobulin M and A. Better immunological efficacy noted when plasmapheresis and plasmapheresis were used in combination with ultraviolet blood irradiation.
RUDN Journal of Medicine. 2012;(2):104-110
pages 104-110 views

Assessmentof psychological rehabilitation of patients with the increased vomitting reflex during dental examination

Strelkov N.N., Nabatchikova L.P., Mitin N.E.


Results of anxiety level investigation before and after orthopedic dental treatment of patients with the increased vomiting reflex are presented in this study. The aim: to asses positive experience influence of orthodontic treatment on the psychological status of a dental patient having the increased vomiting reflex level. Clinical stages of the proper orthopedic treatment allow them to feel fully human, adapted to the society and to have the prophylactic effect for the next dental procedures.
RUDN Journal of Medicine. 2012;(2):111-115
pages 111-115 views

Diagnosis aggregation aspirin resistance in patients after myocardial infarction in the secondary prevention of thrombotic complications

Ogurtsov P.P., Kochetov A.G., Lyang O.V., Politidis R.R., Djappuev A.D.


The use of acetylsalicylic acid as antiaggregant is the standard antithrombotic therapy for secondary prevention in patients with myocardial infarction. But the methods of monitoring and analysis of cause of variable efficiency of this therapy is not currently specified. The purpose of this study was to evaluate platelet aggregation activity in patients with myocardial infarction and analysis of the causes of aggregation aspirin resistance. We examined 79 patients after myocardial infarction receiving aspirin. Presented the characteristics of aggregation curves corresponding to an effective antiplatelet therapy. It was revealed that the development of aggregation aspirin resistance depends on the presence of concomitant diseases, as well as receiving beta-blockers and diuretics, and does not depend on the concentration of platelets and acetylsalicylic acid in the blood.
RUDN Journal of Medicine. 2012;(2):116-121
pages 116-121 views

Standardization of turbidimetric method study rating of platelet aggregation activity

Kochetov A.G., Lyang O.V., Politidis R.R., Ogurtsov P.P., Djappuev A.D.


Investigation of platelet aggregation is great importance in diagnostics of hemostasis, as well as in evaluating the effectiveness of antiplatelet therapy. The aim of this study was to standardize the most common currently turbidimetric method of platelet aggregation studies using different inducers of aggregation and their concentrations. Were examined 38 healthy donors. Represented by the standard types and calculated reference characteristics of the curves of aggregation for the laser aggregometry.
RUDN Journal of Medicine. 2012;(2):122-128
pages 122-128 views

Analysis of domiciliary deaths of urban population

Irzhanov J.A., Chibisov S.M., Shastun S.A.


The study presents the results of the analysis of domiciliary deaths of the population of a municipal polyclinic in Ufa in the dynamics between 2001 and 2010. The differences in the structure of mortality to the cause of death and sex between working-age population and pensioners were revealed. In ten years increased mortality from digestive system diseases (2,1 times) and malignant tumors (11,5%) was registered. For 2010 the mean age of the dead by months, days and time of death was detected. The obtained results were used as a basis for administrative decision making.
RUDN Journal of Medicine. 2012;(2):129-132
pages 129-132 views

Free-radical oxidation and antioxidant protection in periodontitis

Elbekyan K.S., Karakov K.G., Markarova G.W.


Based on the studies the marked suppression of inflammatory processes in the periodontium by melaksenom - a synthetic analogue of epiphyseal melatonin was revealed and its topical application to obtain better therapeutical action in HGP was proved.
RUDN Journal of Medicine. 2012;(2):133-136
pages 133-136 views

Antibacterial effects of copper nanoparticles on clinical strains

Babushkina I.V., Chebotareva E.G., Borodulin V.B., Sakkala М., Borodulina E.V.


Manifested antibacterial action of copper nanoparticles on polyantibioticoresistant clinical strains of bacteria in the concentrations 0,001-1 mg/ml and in different temporary expositions has been determined. High antibacterial activity of copper nanoparticles has been revealed.
RUDN Journal of Medicine. 2012;(2):137-139
pages 137-139 views

The effect of raman-laser irradiation on erythrocytes of rats

Poludnyakova L.V., Arslanova D.R., Abakumova T.V., Voronova O.S., Gening T.P., Belozerova L.A., Kurkov A.S.


The effect of RAMAN-laser irradiation on erythrocytes of rats was investigated. It was established that laser irradiation with doses used increases lipid peroxidation in membranes of red blood cells and stimulates the activity of cellular antioxidant enzymes.
RUDN Journal of Medicine. 2012;(2):140-142
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RUDN Journal of Medicine. 2012;(2):147-152
pages 147-152 views

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