Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C

L I Nikolaeva; Николаева Людмила Ивановна; Е I Sамоkhvalov; Самохвалов Евгений Иванович; S V Al'khovskiy; Альховский Сергей Владимирович; A V Kolotvin; Колотвин Андрей Васильевич; L М Samokhodskaya; Самоходская Лариса Михайловна; V V Makashova; Макашова Вера Васильевна; A К Тokmalaev; Токмалаев Анатолий Карпович

Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C

Authors: Nikolaeva LI¹, Sамоkhvalov ЕI¹, Al'khovskiy SV¹, Kolotvin AV², Samokhodskaya LМ², Makashova VV³, Тokmalaev AК⁴
Affiliations:
1. D.I. Ivanovsky institute of virology
2. М.V. Lomonosov Moscow State University
3. Central institute of epidemiology
4. Peoples' Friendship University of Russia
Issue: No 2 (2012)
Pages: 81-88
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3115
ID: 3115

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Abstract

Aim: to determine influence of genetic polymorphisms of hepatitis C virus and single nucleotide polymorphisms (SNPs) of patients with chronic hepatitis C on achieving sustained virological response (SVR) to antiviral therapy. One hundred blood samples of eastern-Slavonic patients with different response to the therapy were analyzed. It was determined, that among SNPs of 7 human genes only allelic variants of IL-1β, IL-28B, TGF-β1 and viral genotypes can influence on probability to achieve SVR.

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chronic hepatitis C, virological response, genome, polymorphisms, genotypes

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Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C

Full Text

Abstract

Keywords

About the authors

References

Supplementary files