No 2 (2011)

It's necessary to make an effective performance of research work in the conditions of a modern science research automation. This aspect is not realized as full as it need in the Russian medical high schools. Most actual questions of medical education process are introduction and active use of these research automation tools. To solve this problem it is necessary to design some new principles and algorithms of working with them.

Work is devoted to research dynamics of parameters of high resolution ECG (HRECG) and heart rate variability (HVR) methods in patients with acute coronary syndrome in determining myocardial electrical instability and disease trend the carried out. The researches have shown that, the HRECG and HRV variables in acute coronary syndrome, patients have various possible changes, which correlate with the severity of the current disease.

The problem of kidneys lesion remains actual nowadays. The article deals with the literature review on systemic manifestations of chronic obstructive pulmonary disease (COPD), as exemplified by urinary system involvement.

Chronic virus lesions of a liver are one of the principal causes of a growing mortality in the Russian Federation and other countries from a cirrhosis and a hepatocellular carcinoma. At the present day one of the most significant prognostic factors of decreasing efficacy of therapy HCV-infection is insulin resistance (IR). 114 patients, who were treated with Peginterferonα-2b plus Ribavirin within 2008-2010 yrs., were prospectively studied. Patients with IR, but with the normal carbohydrate metabolism (n = 59) have been divided into 2 groups: the 1st group (n = 22) was prescribed combination of Peginterferonα-2b (1,5 mcg/kg per week) and Ribavirin (15 mg/kg per day) + Metformin (20 mg/kg/per day), with their informed consent, the 2nd group (control) - Peginterferonα-2b (1,5 mcg/kg per week) plus Ribavirin (15 mg/kg per day) (n = 37). Thus, IR is specific feature of HCV, irrespective of presence or absence of adiposity. IR is revealed in 37% of patients with normal body weight. Besides the improvement of way of life, diet observance, medical correction of IR in patients on interferon therapy is necessary. Correction of IR by Metformin is reasonable, beginning from value of HOMA-IR ≥ 2, at any genotype HCV, and considerably improves results of Peginterferon α-2b plus Ribavirin therapy, especially in patients with low or normal body weight. Metformin as the third component of Peginterferon α-2b plus Ribavirin therapy is safe and effective. Medical correction of IR is a new aim in treatment of hepatitis C.

We present data on concentrations of serum and follicular fluid hormones in IVF cycles in relation to the number of punctured follicles. Circulating periovulatory estradiol levels correlated positively with the number of punctured follicles. We observed significant decrease in circulating AMH concentrations in periovulatory period compared to baseline levels. Estradiol and progesterone concentrations in follicular fluid did not correlate with the number of follicles or serum levels of these hormones. AMH and inhibin B in follicular fluid were higher in patients with greater number of punctured follicles.

The indexes of cellular and humoral immunity in patients with the cervical ectopies and in pregnant with chronic tonsillitis were studied. Universal and specific compensatory-protective immune responses have been revealed for each nosologic form of pathology. Rational prescription of the natural immunomodulators for treatment of pregnancy complications was recommended.

Long-term outcomes of endodontic treatment of chronic forms of a top periodontitis using FAD method for medicamentous processing root canals are presented in this article. The article presents the study of efficiency of photoactivated disinfection method concerning three species of microorganisms, resistant to traditional endodontic antiseptic processing. Microbiological research has shown high efficacy of FAD method.

In the article the urgency of the development of the algorithms of the pathogenetic dental caries therapy, presenting the same-name protocols is substantiated. The working out principles of protocols for the pathogenetic therapy of the dental caries are presented.

Aim: to study the efficacy of autotransfusion of ozone modified erythrocyte suspension in the complex therapy of extensive psoriasis. 118 patients with progressive stage of extensive psoriasis from the age of 18 to 66 have been investigated. Clinical picture, some indices of coagulogram, protein metabolism, lipid peroxidation and antioxidant protection processes in blood plasma have been studied in dynamics. Inclusion of ozonetherapy in the complex treatment of psoriasis contributed to the more rapid and complete positive dynamics of skin process, decreasing of seromucoid and С-reactive protein level, correction of some impaired coagulogram indices, normalization of the lipid peroxidation process level. The use of plasmapheresis with autotransfusion of ozone modified erythrocyte suspension appears to be the most effective. The tolerability of the procedures was good.

The work is devoted to studying of the functional state of the autonomic nervous system (ANS) of HIV infected patients. Heart rate variability, frequency and severity of vegetative manifestations. were studied in 103 HIV-positive patients. The control group consisted of 23 healthy persons. Obtained data revealed changes of the functional state of ANS along with development of hypersympathicotonia and increasing of frequency and severity of vegetative manifestations as the HIV-infection progressed.