No 1 (2009)

The effectiveness of different probiotic Acilact versions was investigated using animal models. The high protective activity of heat treated Acilact version was demonstrated in the experiments on mice which had suffered the combined radiation and thermic injuries. The effectiveness of medicinal cosmetic cream prepared from the Acilact supernatant was tested on rabbits and monkeys. The experiments on rabbits showed that the inflammatory foci caused by the intracutaneous injection of Staphylococcus culture were repaired more rapidly than in the control group. The cream had a positive impact on the burn and wound healing after traumatic injuries in monkeys.

This article focuses on the necessity of use Intraoperative Transesophageal Echocardiography (IOTEE) in valve replacement surgery. The authors present comparative estimation of IOTEE and the method of visual surgical revision in the intraoperative detection of paravalvular leaks.

In task present 2 case intraoperative left ventricular rupture, an AMI, not indeterminate on clinic. This case was present of new pathogenic mechanism of left ventricular rupture.

25 patients with advanced diffuse pulmonary emphysema underwent 27 operations from 2000 to 2008. Our data show that for some patients with homogenous emphysema unilateral lung volume reduction surgery can improve spirometric and symptomatic signs, life quality and therapy effectiveness.

In this article the analyses of different ways of endoscopic hemostasis is given. The most perspective variant to the authors weuw is the combined one, what is proved by the large clinical material.

Results showed that patients who received intravenosus laser irradiation of blood and low intensive laser irradiation in addition to tradicional treatment showed reduction of inflammatory process. It occurs due to influence on patogenetic steps of acute pyelonephritisd and confirmed by data ortained at laboratory, мicrobiological, instrumental rentaenological and VS-methods of examination.

Work is devoted to complex studying of electrophysiological parameters of a myocardium according to new methods of an electrocardiogram of diagnostics and intensity of free radical oxidation processes at patients with acuter coronary syndrome. The analysis of the remote results (lethal and repeated hospitalization) and their communication with parameters of an electrocardiogram of the high resolution and dispersive mapping in the period of aggravation IHD, comparable with the clinical data of speed of displays of disease before hospitalization is carried out. It is investigated prognostics value of a parameter free radical oxidations.

Protective and normalizing mildronate action on the level of non enzyme kation proteins in the neurophils and contents of kateholamins in erythrocytes were revealed on the experimental model of the emotional-pain stress. The findings of numerous investigations demonstrate that positive effects of mildronate were connected not only with its metabolism-modifying action but with accumulated holinolike metabolites of karnitine and normalizing influence on the central parts of neuro-endocrine systems, which ensure its use with the aim of increasing of adaptation to the outer environmental factors as well at to the prolonged phycho-emotional overstrain.

In article results of scientific researches of employees of a course of restorative medicine are presented possibilities hirudotherapy in correcting of neuropsychological frustration at patients of polycythemia vera without use of medicaments.

Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at least 2 isoforms. COX-2 has been suggested to be the isoform primarily responsible for synthesis of prostaglandins (PGs) in the context of inflammation. Thus, selective inhibitors of COX-2 were developed with the aim that they would be as effective as traditional nonsteroidal antiinflammatory drugs (NSAIDs) but would not be as damaging to the gastrointestinal tract by virtue of not inhibiting the primarily COX-1-dependent PG synthesis in those tissues. To investigate whether selective COX 2 inhibitors would play a role in a model of inflammation. The received results testify to ability of COX 2 inhibitors to increase adhesion and modulation of apoptosis and PMN free oxygen radicals production. The drugs' effect on PMN free oxygen radicals production, apoptosis and adhesion may constitute an additional mechanism of their activity. These data characterize the potential mechanism to explain effects immunomodulatory agents of pathway and therapy for inflammation, cardiovascular diseases and bronchial asthma; beta-adrenergic receptors are functionally coupled to signalling cascades in human neutrophils These results clearly confirmed that COX-2 plays a critical role in the development of the inflammatory response by altering key components of the inflammatory cascade. Therefore, selective inhibitor of COX-2 such as celecoxib, offers a therapeutic approach for the management of various inflammatory diseases.

In article are considered questions of a state of health of the pupils trained at schools of new type. The data of complex researches of same children has shown that for five years at schools with profound studying of foreign languages the tendency to reduction of percent of pupils with the first group of health is marked. Creation of system of health protection of schoolboys in educational institutions; working out of new technologies of carrying out of preventive maintenance taking into account differentiation of medical monitoring depending on degree of risk of formation of infringements of health will allow to keep health of pupils.

In article are given the ekologo-hygienic characteristic of subjects of the Central federal district of the Russian Federation and the disease analysis on the basic classes of illnesses of children living in territories with various degree of pollution. The consumer approach to the natural resources, unreasoned development of manufactures without ecological consequences have led to occurrence of dangerous regions of the country and separate zones with intense ecological conditions, and, hence, to deterioration of health of people and that is the most dangerous, - children.