No 1 (2012)

This study is dedicated to serotoninergic structures of the colon. Experiments were performed in 35 Chinchilla rabbits under general anesthesia, mechanical ventilation, bilateral vagotomy. Mechanical and electrical activity of the ascending colon was recorded during electrical stimulation of the peripheral part of the right n. vagi in intact animals and after serotonin adipate injection. It was found that serotonin potentiates vagal effects of the colon, but without effect on duration of reaction. Concluded that the serotoninergic structures of the colon are able to control the parasympathetic portion of the autonomic nervous system.

The hormonal and immune status of the macroorganism affects adhesive capacity of host's cells. In the present study we managed to confirm this postulate demonstrating that clinical isolates of Candida albicans species are increasing their adhesive activity to vaginal epithelial cells during the highest concentration of estrogen. This property in equal degrees characteristic of both C. albicans cells types, isolated from women with symptomatic or asymptomatic vaginal candidosis.

Поддержка: США. Национальный Институт Здоровья(GM-13981)(FH), Миннесотский Технологический Институт(GC, FH) На протяжении нескольких десятилетий было проведено хронобиологическое мониторирование сердечно-сосудистых, психофизиологических, эндокринных и других показателей, включая температуру ядра. Полученные показатели обладают широким спектром периодов, некоторые из которых имеют аналогичные показатели с земными, межпланетарными и солнечными ритмами. Было проведено картирование циркасептальных, цирканнуальных ритмов изучаемых параметров. Установлено, что имеется определенная степень синхронизации ритмов, которая затухает при отсутствии или уменьшении активности окружающей среды и возрастает с активацией этой среды. Аналогичная направленность показателей была выявлена для периодичности ритмов террористических атак и крупных землетрясений. Синхронизация(копериодизм) циклов биосферы с циклами гидросферы, атмосферы, ионосферы и т.д. обосновывает создание междисциплинарного термина хроносфера («хронос» - время, «сфера» - земной шар). Изучение хроносферы позволяет избежать последствий природных катаклизмов, а хронобиологическое мониторирование сердечно-сосудистой системы является значительно более эффективным способом предупреждения заболеваний по сравнению с обычной системой медицинского наблюдения.

The work is devoted to investigation of functional characteristics of β-adrenoreceptors in the aged patients with exacerbation of chronic obstructive bronchitis. On the base of obtained data the administration of m-cholinolytics for bronchodilatation is proved.

The state of haemodynamics and blood circulation energy supply was investigated in patients with uncomplicated moderate flu in 44 patients aged from 51 to 60 years by tetrapolar thoracic rheography The emergence of a small release syndrome, decreased contractility and mechanical activity of the heart, the transition to the energetically more economical type of blood circulation regulation were identified, what can be considered as compensatory adaptive reaction in hypocirculation. However, developing compensation is imperfect, as accompanied by an increased energy cost of performed work. These violations persist for a long time, and can serve as risk factors for complications and diseases of the cardiovascular system.

The comparative analysis of the influence of various methods of anaesthesiological assistance on some parameters of mother's haemodynamics for patients with hypertension has been performed. The parameters of central haemodynamics by noninvasive bioimpedance technology have been assessed in 40 patients. They were divide into two groups: 20 - group with sevofluran anaesthesia, 20 - group with spinal anaesthesia. Our results indicate that spinal anaesthesia gives more favorable changes of haemodynamics parameters versus sevoflurane anaesthesia. There were significant difference in Apgar scores at 1 min and no differences at 5 min in general and spinal groups.

The work is based on the analysis of treatment of 162 patients with gastric polyps. A comparative analysis of electrosurgical and radio-wave methods of polypectomy was performed. The both methods of excision of gastric polyps were equally effective, and radio-wave polypectomy was accompanied by less number of complications. The results of long-term follow up propose a lower rate of recurrent polyps after radio-wave polypectomy.

In this study, efficacy of a Visual Analogue Scale (VAS), of a Numeric Rating Scale (NRS) and of a Lightning Scale (LS) proposed by authors in measurement of pain of ENT patients were compared. Following correlation coefficients were obtained: R = 0.8011 (VAS vs. LS), R = 0.8317 (NRS vs. LS), R = 0.8395 (VAS vs. NRS). Lightning Scale can be suggested for urgent ENT for diagnosing and selection of analgesic.

In this article the results of using laser-fluorescent diagnostics (LFD) method in patients with purulent diseases are demonstrated. LFD allows making an adequate assessment of the patient's rehabilitation process on the amplitude-spectral objective characteristics; to define dates of convalescence, to reveal complications and to correct an option of drug therapy in time. Such technology permits to prevent complications and reduce the time of treatment for 2-15 days (depends on severity of disease).

Cases of 120 patients were analyzed retrospectively. Early (to 4 days) and late (after 5 days) tracheostomy were compared. No differences in occurrence of ventilator-associated pneumonia, in duration of mechanical ventilation and length of hospital stay between the groups were revealed. Length of intensive care unit stay was less and there was a higher rate of good recovery in the early tracheostomy group.

The theoretical analysis of issues related to designing a virtual morphological workshop, showed the necessity to set some principles for its development. In this work the structural organization of the virtual laboratory and five principles of software development are described.

Role of the immune system in patients with primary syphilis continues to be relevant according to high incidence of disease in Russia and poorly studied this question. Comprehensive study of all indicators of phagocytosis in the immune status in case of primary syphilis in available scientific literature was not found. Thereby, the study of immune reactivity of the macroorganism with different variants of syphilis is an important problem which solution may contribute to the development of prognostic criteria of this disease.

Action of copper nanoparticles on the properties of the cell cultures: HеLа, Х563 (myeloma of mice) and newly released bone-marrow cells from the patients with multiple myeloma was studied. The percentage of the lost cells of the cultures, dystrophic changes in cells were estimated. The results of investigation showed the opportunity of induction of cytotoxic and antiproliferative processes by copper nanoparticles in vitro.