No 3 (2015)


The blockade of the reinforcing effects of angiotensin-II on hemodynamic parameters in rats with experimental diabetes mellitus

Serova O.N., Kalashnikova E.Y., Elfimov A.I., Lagutina L.V., Torshin V.I.


Diabetes mellitus (DM) causes not only carbohydrate metabolism, but and disorders of the cardiovascular system, resulting in developing hypertension. It is known that in the regulation of hemodynamics the renin-angiotensin system plays an important role, the effector peptide of which is angiotensin II (A-II) causes hypertension and increases the heart rate (HR). In this work we studied the change in systolic blood pressure (SBP) and HR under the action of A-II in rats with experimental autoimmune type 1 DM. Autoimmune diabetes in Wistar rats was induced by injections of streptozotocin. Two weeks after the third injection, SBP and HR were measured in animals. The day before the start of the experiment the blood glucose level was detected. The results showed the absence of hypertensive properties of A-II and its reinforcing effect on HR in rats with autoimmune diabetes, indicating diabetic hyperglycemia as the main factor in the ineffectiveness of the action of A-II on hemodynamic parameters. It can be assumed that the significant increase of blood glucose level in condition of autoimmune diabetes type 1 DM occurs specific desensitization of receptors to A-II in the central and peripheral structures governing the SPB and HR, i.e., the blockade of the physiological action of this peptide.
RUDN Journal of Medicine. 2015;(3):9-13
pages 9-13 views

Medical activity and gynecological morbidity of women of different ages

Shmelev I.A.


The article presents the estimation of medical activity of the interviewed women with and without gynecological diseases. Discusses peculiarities of medical activity depending on the age and level of education of women. Main causes of irregular prenatal visits are determined.
RUDN Journal of Medicine. 2015;(3):14-17
pages 14-17 views

Assessment of risk factors of health losses in the public sector employees

Vvedensky A.I.


The article presents data on risk factors for chronic non-communicable diseases on the results of additional medical examination of persons employed in the public sector (doctors, teachers, social workers) and living in the Ryazan region. According to a sociological survey, it was found more common among workers in the public sector, compared to the general adult population, risk factors such as poor nutrition, high stress levels, lack of concern for their health, tobacco smoking and physical inactivity.
RUDN Journal of Medicine. 2015;(3):18-24
pages 18-24 views

Magnetocardiographic QRS complex in patients with paroxysmal atrial fibrillation and chronic obstructive pulmonary disease

Ivanov G.G., Bulanova N.A., Vostrikov V.A., Dvornikov V.E., Chuiko N.A., Halabi G., Aleksandrova M.R., Maslennikov Y.V., Prinin M.A., Nedaivoda I.V., Kuznetsova S.Y., Gunaeva V.N.


In this study, the analysis of magnetocardiographic (MCG) data for the three groups of patients is given. The first group included 31 healthy volunteers, who had no “history” of a heart disease. The second group included MCG record of 51 patients with chronic obstructive pulmonary disease (COPD). The third group consisted of 31 MCG records for patients with paroxysmal atrial fibrillation (AF). Founded advantages of MCG to potential method provide registration and mapping features of electrophysiological processes in the heart, when the change takes place at the MCG and often absent on ECG.
RUDN Journal of Medicine. 2015;(3):25-39
pages 25-39 views

Evaluation of autonomic nervous system in patients with chronic rhinosinusitis and olfactory disorder

Dyomina E.N., Kastyro I.V., Drozdova G.A.


Studied cardiointervalography of 45 men with chronic rhinosinusitis and impaired olfactory function. In the studied group of patients predominance sympathotony was revealed. It is also shown that the detection of the initial state of the autonomic nervous system plays a role in non-pharmacological treatment of chronic rhinosinusitis with with impaired peripheral olfactory analyzer.
RUDN Journal of Medicine. 2015;(3):40-45
pages 40-45 views

Digital Tomosynthesis in Diagnosis of impalpable Breast Cancer

Grinberg M.V., Harchenko N.V., Kunda M.A., Zapirov M.M., Rozhkova N.I.


Purpose . To compare the diagnostic performance of digital breast tomosynthesis (DBT) and digital mammography (DM) for breast cancers. Materials and Methods . The study included fifty-seven patients with histologically verified breast cancer. Given the subjective evaluation of the benefits of technology for tomosynthesis imaging of pathological signs characteristic of breast cancer (tumour, focal asymmetry, restructuring or microcalcifications). The data obtained on the base of DM and additional DBT information were assessed according to BI-RADS scale (force BI-RADS). The interdependence between the categories according to BI-RADS scale and the nature of the radiological manifestations of breast cancer was determined using Chi-square (c 2) test. Results . A total of 59 breast cancers were reviewed, including 17 (28.8%) mass lesions, 12 (20.3%) focal asymmetry/density, 6 (10.2%) restructuring, 23 (39.0%) calcifications, and 1 (1.7%) intracystic tumor. Mammography with DBT was more informative to visualize 58.8% of the lesions, 83,3% of focal asymmetry, 94.4% of violations architectonics and only 11.6% of the signs of microcalcifications. When making conclusion on BI-RADS scale, in 84.4% of cases category of findings was increased from 0 (when performing DM) to 4 or 5 (when performing DBT). Category opinions 4A on the scale of BI-RADS in the implementation of DM in 27.3% of cases was increased after evaluation of the images of the DBT, a symptom of malignancy in this category were mainly detected microcalcifications. Significant interdependence ( p < 0,001) between BI-RADS category and pathological radiographic signs was noted. Conclusion . DBT allows to obtain more accurate visual information about mass formation, focal asymmetry, violation of the architectonics and improves the diagnostic efficacy of mammography.
RUDN Journal of Medicine. 2015;(3):46-60
pages 46-60 views

Clinical and anatomical substantiation of application of modular femoral neck components in primary total hip arthroplasty

Ptitsyn K.A., Epstein A.A., Kopylov A.A., Belyak E.A., Kubashev A.A., Prizov A.P., Abdulkhabirov M.A., Lazko F.L.


The article presents the results of primary total hip arthroplasty in 108 patients using modular systems necks femoral components. In our study, straight modular necks were used in 56.5% of cases, angled modular necks - in 43.5 %, which shows the possibility of using modular neck in all patients, especially in severe cases.
RUDN Journal of Medicine. 2015;(3):61-66
pages 61-66 views

Prediction of prostate cancer by the general discriminant analysis models

Kostin A.A., Asratov A.T., Kulchenko N.G., Tolkachev A.O.


The study presents a retrospective analysis of risk factors for prostate cancer in 122 men. First, a comparative analysis of many factors: age, weight, bad habits, levels of testosterone and of prostate-specific antigen (PSA), comorbidities, blood group, RH factor, manual rectal investigation, the results of the prostate ultrasound was conducted. Next, using general models of discriminant analysis, five of the most significant risk factors for prostate cancer were identified: inflammatory diseases of the kidneys and bladder, increased PSA blood test, blood group, overweight patient. Applied discriminant equation containing the five most informative features, allows up to 97.5% to predict the likelihood of developing prostate cancer.
RUDN Journal of Medicine. 2015;(3):67-74
pages 67-74 views

Production of growth factors in benign and malignant prostatic diseases

Kostin A.A., Andriukhin M.I., Babichenko I.I., Pul’bere S.A., Motin P.I., Tal’berg P.I.


Iimmunohistochemical study of localization of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 and cells proliferative activity by Ki-67 protein has been carried out in benign prostatic hyperplasia (BPH) and adenocarcinoma (AC) of different grades by the Gleason score. A moderate positive correlation between the Gleason score and cell proliferation Ki-67 index ( rs = 0,674) and a moderate negative correlation with the level of such score and expression of matrix metalloproteinase-9 ( rs = -0,660) were detected. A weak significant negative correlation exists also between the level of proliferative activity of secretory cells and the expression of MMP-9 by tumor cell ( rs = -0,369). A significant decrease of the MMP-9 and TIMP-1 levels in the AC of different gradations have been found. The invasive properties of tumor cells, which are expressed in the destruction of collagen IV of basement membrane and connective tissue stroma of the prostate, associated with an imbalance between MMP-9 and protein blocking this enzyme - TIMP-1, expression of which decreases in AC compared to BPH.
RUDN Journal of Medicine. 2015;(3):75-83
pages 75-83 views

Complex diagnosis of parietal formations of the thoracic cavity

Glagolev N.A.


The work is devoted to computed tomography (CT) and ultrasound (US) diagnosis of the thoracic cavity diseases, which highlights many of the issues in the literature clearly or not covered at all. Advances in the CT and US technologies have demanded reconsideration of the scientific data about value of these methods in diagnostics of diseases of lungs and pleurae. Now US is widely used in the diagnosis of diseases of the organs and tissues of the abdominal cavity, retroperitoneal space, pelvic organs, cardiovascular system and is insufficiently used for the study of pathological changes of lungs and pleura. The analysis of possibilities of US and CT in diagnosis of parietal thoracic cavity formations and indications for ultrasound are presented, the US technique as well as US semiotics of revealed pathological changes are described. Implementation into clinical practice of modern methods of diagnosis increases the chance of early detection of the disease when it is still possible to use the radical methods of treatment
RUDN Journal of Medicine. 2015;(3):84-97
pages 84-97 views

Juvenile ankylosing spondylitis: the criteria approach

Volkov M.Y., Kantemirova M.G., Brilkova T.V., Glazyrina A.A., Rogatkin P.S., Ovsyannikov D.Y.


Juvenile ankylosing spondylitis (UAC) is a chronic progressive disease characterized by nonspecific clinical picture at the onset and late spine involvement. The article presents a clinical case of UAC progressed with migratory pain syndrome after an upper respiratory tract infection, early-onset spine lesions and ineffective therapy by non-steroidal anti-inflammatory drugs in patient of 11 years old. The criteria approach to the diagnosis of UAC is discussed.
RUDN Journal of Medicine. 2015;(3):98-106
pages 98-106 views

Functional disorders of the upper gastrointestinal tract in premature infants: pathogenetic aspects of the development of microaspiration gastric contents

Bryksina E.Y., Bryksin V.S.


The article gives the detailed characteristics of the anatomo-functional features of the gastrointestinal tract of newborns and highlights the most important pathological factors promoting development of functional pathology of the upper gastrointestinal tract in the neonatal period. Pathogenetic mechanisms of development of microaspiration of gastric contents, and the nature of influence of microaspiration gastric contents on the bronchopulmonary system in newborns are presented.
RUDN Journal of Medicine. 2015;(3):107-116
pages 107-116 views

Repeated caesarean section in modern obstetrics. Are there decreasing reserves?

Gumeniuk E.G., Kormakova T.L., Karpechenko A.V., Marabjan L.M.


The analysis of the problem of сaesarean section (CS) in modern obstetrics is performed. Analysed 156 cases of repeated CS. Indications for the first and repeated operation, postoperative complications are studied. Discussed possible reserves to reduce the incidence of the first and repeat caesarean section.
RUDN Journal of Medicine. 2015;(3):117-122
pages 117-122 views

Myotonometry of patients with transverse incisor occlusion

Bogaevskaya O.U., Peshkin V.I.


Studied the tone of masticator muscles in patients of 13-15 years with transversal incisor occlusion. All patients were divided into two groups, depending on the dental occlusion: 1 st - physiological; 2 nd - distal. Based on these data the performance features of the contractility of the masticator muscles, depending on a type of occlusion of the posterior teeth are defined.
RUDN Journal of Medicine. 2015;(3):123-126
pages 123-126 views

A case of severe anorexia nervosa in medical worker

Bryukhin A.E., Artemieva M.S., Fedyai S.O., Suleymanov R.A., Grigorieva J.V.


The article discusses the features of eating disorders among health care workers. Discovered that eating disorders may increase awareness of this category of persons about the properties of diuretics, laxatives, anorectics, as well as about medical procedures, leading to body weight loss.
RUDN Journal of Medicine. 2015;(3):127-130
pages 127-130 views

Participation of students in research of blood microcirculation at the department of human anatomy

Gurova O.A.


The Department of human anatomy PFUR under the guidance of head of Department Professor V.I. Kozlov for many years conducted research of blood microcirculation. Students actively participate in scientific research. Within the problem of adaptation of students to educational stress studies of microcirculation of blood and heart rate variability in students of 1 st and 2 nd courses in the dynamics of the school day, week and year. Increased tension of regulatory mechanisms observed in the teaching periods: at the beginning of the study after the holidays, in winter session during the week - on Wednesdays and during the school day - in 14-16 hours. These peculiarities of the functioning of the cardiovascular system of students should be considered in making out schedule.
RUDN Journal of Medicine. 2015;(3):131-138
pages 131-138 views

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RUDN Journal of Medicine. 2015;(3):139-144
pages 139-144 views

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