Interaction between people is a cornerstone of being human. Despite huge developments in languages and communicative skills, interaction often fails, which causes problems and costs in everyday life and work. An inability to conduct dialogue also produces conflicts between groups of people, states and religions. Therefore, there are good reasons to claim that miscommunication and failures in interaction are among the most serious problems in the world. Researchers from different fields - linguistics, sociology, anthropology, psychology, brain research, philosophy - have tried to tackle this complex phenomenon. Their method-driven approaches enrich our understanding of the features of interaction in many ways. However, what is lacking is an understanding of the very essence of interaction, which needs a more holistic, phenomenon-driven approach. The aim of this paper is to show that the only way to reach this goal is multidisciplinarity, that is, using the results and methods of different fields of research. This is not an easy goal and task because the way of thinking and doing research varies greatly discipline-wise. A further obstacle is the researchers’ training, which, as a rule, focuses on the tradition of only one field of research. The Multidimensional Model of Interaction provides a good framework for a more holistic approach to interaction by viewing the complex phenomenon from different angles. The model includes various phases of the process of interaction, beginning with the choice of the topic by the speaker and ending with identification of the reference by the recipient, as well as the mental worlds of the interlocutors (knowledge, attitudes, values, emotional state etc.), recipient design (accommodation of speech) and external circumstances.