Expression of intermediate filaments and cell cycle regulators in bladder tumors

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Abstract

Intermediate filament (CK20) and cell cycle regulators (P53, Ki-67) were evaluated by immunohistochemical technique in 32 samples of bladder tumors (Ta - 8, T1-2G1-2 - 20, T1G3 - 3 and T2G3 - 1). Research has shown that intensity of P53 staining allow to defined the grade of tumor cells. Pathological type of CK20 distribution in cells and its high proliferative index (Ki-67) permit to reveal invasive urothelial tumors.

About the authors

I A Shalavin

People's Friendship University of Russia

Кафедра патологической анатомииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

I I Babichenko

People's Friendship University of Russia

Кафедра патологической анатомииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

S A Osipov

Central Clinical Hospital of the Russian Academy of Sciences

Отделения урологии и патологической анатомии; ЦКБ РАН; Central Clinical Hospital of the Russian Academy of Sciences

M V Samoylov

Central Clinical Hospital of the Russian Academy of Sciences

Отделения урологии и патологической анатомии; ЦКБ РАН; Central Clinical Hospital of the Russian Academy of Sciences

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Copyright (c) 2008 Шалавин И.А., Бабиченко И.И., Осипов С.А., Самойлов М.В.

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