Аbout typical responses of the damaged heart

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Abstract


On the basis of experimental research we described nine typical (nonspecific) responses of the damaged heart which are initially protective and adaptive but are able to have a pathogenetic character under some certain conditions. These typical responses are as follows: shortening of the effective refractory period of the myocardium, cardiomyocyte mitochondrion swelling, activation of lysosomal apparatus, initial intensification of lipolysis, hypertrophy of cardiac muscle, formation of collagen muffs around blood vessels due to intoxication, functional deafferentation of the heart, changes in the intensity of cardiomyocyte apoptosis, rearrangement of cardiac chronostructure. The represented results can be used as a basis to elaborate some new effective methods of prophilaxis and treatment of heart diseases caused by different etiological factors.

V A Frolov

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

D P Bilibin

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

M L Blagonravov

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

G A Drozdova

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

S M Chibisov

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

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Copyright (c) 2011 Фролов В.А., Билибин Д.П., Благонравов М.Л., Дроздова Г.А., Чибисов С.М.

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