Regulation of neurogenesis and cerebral angiogenesis by cell protein proteolysis products

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Abstract


Brain development is a unique process characterized by mechanisms defined as neuroplasticity (synaptogenesis, synapse elimination, neurogenesis, and cerebral angiogenesis). Numerous neurodevelopmental disorders brain damage, and aging are manifested by neurological deficits that are caused by aberrant neuroplasticity. The presence of stem and progenitor cells in neurogenic niches of the brain is responsible for the formation of new neurons capable of integrating into preexisting synaptic assemblies. The determining factors for the cells within the neurogenic niche are the activity of the vascular scaffold and the availability of active regulatory molecules that establish the optimal microenvironment. It has been found that regulated intramembrane proteolysis plays an important role in the control of neurogenesis in brain neurogenic niches. Molecules generated by the activity of specific proteases can stimulate or suppress the activity of neural stem and progenitor cells, their proliferation and differentiation, migration and integration of newly formed neurons into synaptic networks. Local neoangiogenesis supports the processes of neurogenesis in neurogenic niches, which is guaranteed by the multivalent action of peptides formed from transmembrane proteins. Identification of new molecules regulating the neuroplasticity (neurogenesis and angiogenesis). i. e. enzymes, substrates, and products of intramembrane proteolysis, will ensure the development of protocols for detecting the neuroplasticity markers and targets for efficient pharmacological modulation.


About the authors

E. A. Teplyashina

Krasnoyarsk State Medical University

Author for correspondence.
Email: elenateplyashina@mail.ru
ORCID iD: 0000-0001-7544-3779
Krasnoyarsk, Russian Federation

Y. K. Komleva

Krasnoyarsk State Medical University

Email: elenateplyashina@mail.ru
ORCID iD: 0000-0001-5742-8356
Krasnoyarsk, Russian Federation

E. V. Lychkovskaya

Krasnoyarsk State Medical University

Email: elenateplyashina@mail.ru
ORCID iD: 0000-0002-4017-1125
Krasnoyarsk, Russian Federation

A. S. Deikhina

Krasnoyarsk State Medical University

Email: elenateplyashina@mail.ru
Krasnoyarsk, Russian Federation

A. B. Salmina

Krasnoyarsk State Medical University

Email: elenateplyashina@mail.ru
ORCID iD: 0000-0003-4012-6348
Krasnoyarsk, Russian Federation

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