No S5 (2013)


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Perinatal outcomes and preterm birth risk

Orazmuradov A.A., Lukaev A.A., Knyazev S.A., Shiskin E.A., Apresyan S.V., Vatagina M.A., Kirienko A.F., Nurmiradova Z.K.


Questions about the method of delivery in incomplete pregnancy always remained and would remain relevant. One of the main causes of perinatal mortality in preterm infants is a generic injuries, largely due to inadequate maintenance of preterm birth. Selection of the optimum tactics of perinatal risk factors — the most important reserve for improving the health status of newborns.
RUDN Journal of Medicine. 2013;(S5):10-15
pages 10-15 views

Indicators endointoxication and kidney function in pregnant women with portal hypertension

Britvina K.V., Vasilyeva Z.V., Kitsenko E.A., Mitichkin A.E., Apresyan S.V.


This article discusses the results of studies azotovydelitelnoy and filtration function of the kidneys, as well as indicators of endogenous intoxication in pregnant women with portal hypertension and baby on the content of middle molecules in the blood, urine and amniotic fluid.
RUDN Journal of Medicine. 2013;(S5):16-21
pages 16-21 views

Risk factor of recurrent fetal growth with restiction

Nikolaeva M.G.


The case-control study was designed to determine prevalence and risk factors of fetal growth restriction (FGR) in 588 women. Two hundred fifty three factors were analyzed. It’s shown, that FGR history 6.1-fold increases the risk of FGR in consecutive pregnancy (OR 6.1; CI 95% 3.7—10.0; p < 0.001). Main FGR risk factors are obesity (OR 7.6; CI 95% 2.0—29.2; p = 0.037), more than two cases of early pregnancy loss in history (OR 3.2; CI 95% 1.9—9.2; p = 0.037), chronic endometritis (OR 4.1; CI 95% 1.6—10.6; p = 0.006).
RUDN Journal of Medicine. 2013;(S5):22-27
pages 22-27 views

IVF performance and complications of I trimester of pregnancy the extent IVF in women with latent iron deficiency

Samykina O.V.


We studied early pregnancy complications in pregnancies following in vitro fertilization. The trial included 140 women who were divided into groups according to the presence of latent iron deficiency. In patients with latent iron deficiency frequency of threatened miscarriage and early reproductive loss, as well as the frequency of bacterial vaginosis was significantly higher. In addition, the clinical pregnancy rate was significantly lower in women with latent iron deficiency.
RUDN Journal of Medicine. 2013;(S5):28-33
pages 28-33 views

Clinical features of early pregnancy and magnesium content of the blood serum and erythrocytes in women with undifferentiated connective tissue dysplasia

Nikiphorova N.V., Kerimkulova N.V.


A prospective study found that early pregnancy in women with undifferentiated connective tissue dysplasia is characterized by a higher frequency of complications. А significantly lower magnesium content in erythrocytes of pregnant women with dysplasia was determined. The decrease of magnesium in red blood cells in women with dysplasia less than 1.65 mmol/L can be used as a predictor of the risk of retrohorial hematoma.
RUDN Journal of Medicine. 2013;(S5):34-38
pages 34-38 views

Gestational weight galns in the first trimesrter and risk of pathological birth weight deviations

Nikiforovsky N.K., Pokusaeva V.N.


The cohort study of 467 pregnant women. Analysis has indicated impact of body weight gains in the first trimester on antenatal fetal growth. Low body weight gain or weight loss in early pregnancy were associated with increased risk of small for gestational age. And on the contrary, a fast weight gain with accumulation of a fatty component was associated with the subsequent macrosomia.
RUDN Journal of Medicine. 2013;(S5):39-43
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3D Doppler ultrasound of placental blood flow in the prediction of a missed miscarriage

Fomina M.P.


Reduced placental vasculature was revealed using 3D Doppler ultrasound at 8—14 weeks' gestation in 25 women who had missed miscarriages in 2—6 weeks. The values of placental vascularization index below 10,8% and vascularization flow index less than 3,6 at 8—14 weeks' gestation are predictors of missed miscarriages and early placental insufficiency.
RUDN Journal of Medicine. 2013;(S5):44-50
pages 44-50 views

Will missed abortion repeat again? Programme of action

Dimitrova V.I., Dimitrova D.A., Slusareva O.A.


Developed algorithm of the preventive treatment and rehabilitation procedures to manage missed abortion has decreased risk of having repeated missed abortion in 3/ 4 of the patients.
RUDN Journal of Medicine. 2013;(S5):51-54
pages 51-54 views

Markers of oxidative modification of proteins in the non-developing pregnacy

Tishkova O.G., Dikareva L.V., Teplij D.L.


Prospective analysis of 60 cases with non-developing and normal pregnancy, clinical, biochemical, transvaginal sonography, statistical, histopathological.
RUDN Journal of Medicine. 2013;(S5):55-60
pages 55-60 views

The value of endothelial dysfunction markers in the pathogenesis of morphological and functional changes of chorion in women with previous reproductive loss

Pobedinskaya O.S., Ajeni Daniel Olusola -., Ordiianc I.M.


The value of the markers of endothelial dysfunction in the pathogenesis of morphofunctional changes chorion in women with early reproductive losses. The principal causes of intravascular cytotrophoblast invasion insufficiency are: reduction of NOs level and E-celektine level in serum samples and a rise in Endothelin-1 levels, which correlates with the changes of circulating population of platelets — depressed numbers of platelets at rest, rising of quantity of degenerated platelets which leads to a low vascular resistance in the uterine, spiral and radial arteries. Definition of markers of endothelial dysfunctions, changes in parameters of the morpho-functional states of platelets, increase in the quantity of degenerated platelets and ultrasonic estimation of the blood flow in the uterine, spiral and radial arteries may serve as prognostic criteria to determine the end result of early pregnancy losses.
RUDN Journal of Medicine. 2013;(S5):61-65
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Microbial colonization and nosocomial infections in preterm infants in the neurosurgical hospital

Narogan M.V., Vorona L.D., Petraki V.L., Prokopev G.G., Simernitskiy B.P., Zaharova N.I., Malyutina L.V., Beketovskiy V.Y.


Work is devoted to studying of microbial colonization and infection associated with health care in preterm infants with severe intraventricular hemorrhage (IVH) to evaluate the formation of antibiotic-resistant strains and the choice of treatment. In preterm with IVH complicated by progressive hydrocephalus revealed different variations of the colonization of hospital microorganisms, which changed over hospital treatment. The main microorganisms, which colonized mucosa of oropharynx, respiratory tract and intestines, were Gram negative bacteria multiresistant to antibiotics. In patients receiving long-term antibiotic therapy (1,5 months or more), despite the use of antifungal drugs, appeared fungal flora; in 15% of cases — types of Candida non-albicans. The cause of nosocomial ventriculitis in infants with post-hemorrhagic hydrocephalus in 70% had Gram positive organisms, in 30% — combined bacterial and fungal infection. When choosing a treatment strategy for these children must take into account the results of microbiological studies and antibiogram.
RUDN Journal of Medicine. 2013;(S5):66-72
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Predicting risk of congenital malformations the fetus at the planning stage of pregnancy and early prenatal period

Marapov D.I., Gilmanov A.A., Khasanov A.A.


The authors constructed a model by the method of binary logistic regression, which allows to predict the occurrence of congenital malformation of the fetus depending on the presence of risk factors in women, preparing for pregnancy. The proportion of true predictions using the regression model was 76,5%.
RUDN Journal of Medicine. 2013;(S5):73-79
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The features of mesenchimal stromal cells of normal endometrium and endometrium from patients with different gynecological diseases

Anikina T.A., Radzinsky V.E., Rubina K.A., Sysoeva V.Y.


This is the only experimental study that offers mechanical isolation of stromal cells from normal endometrium and endometrium from patients with adenomyosis, uterine myoma and endometrial hyperplasia. Endometrial stromal cells have been cultured and characterized. And there are comparative data on the expression of surface markers, which are phenotypic features of mesenchimal stem cells, by endometrial stromal cells.
RUDN Journal of Medicine. 2013;(S5):80-87
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Molecular and cellular determinants in the diagnosis endometrial hyperplasia

Shapievsky B.M., Pavlova E.A., Arakelov S.E., Ordiyanc I.M.


We analyzed clinic morphological peculiarities of hyperplastic processes in endometrium of patients during menopausal period and educed molecular and cellular nosotropic determinants of illness; presented evaluation of efficiency of immunihistochemistry of biomolecular markers of proliferation and apoptosis (Ki67, р27, р53 и cyclin E), and also receptor status of endometrium. The author detected relationship between the contents of markers and morphological form of hyperplastic process.
RUDN Journal of Medicine. 2013;(S5):88-92
pages 88-92 views

Descriptiveness complex AMG, Inhibin B, FSH in the diagnosis of menopause age

Totchiev G.F., Kotikova N.P.


The state of the ovaries in women who are in the perimenopausal period, studied the significance of ovarian reserve tests in predicting the onset of menopause and menopausal disorders. Found effective definition of a complex endocrine markers inhibin B, FSH, and AMH to predict the onset of the menopausal transition.
RUDN Journal of Medicine. 2013;(S5):93-96
pages 93-96 views

Optimization of patient management during preimplantacionnoj genetic diagnosis

Bazanov P.A., Mityushina N.G., Yutkin E.V., Voskoboeva E.Y.


The article presents a study on optimization of patients who showed an preimplantacionnoj genetic diagnosis (PGD), identifying opportunities for expanding the range of indications for PGD, and show the validity of the PGD have fertile patients.
RUDN Journal of Medicine. 2013;(S5):97-104
pages 97-104 views

Rehabilitation of reproductive function after surgical treatment of common forms of external genital endometriosis

Oparin I.S., Trocenko I.D., Dukhin A.O.


The study included 155 women of reproductive age with extended forms of genital endometriosis. The developed algorithm of treatment has improved the reproduction health after treatment this disease.
RUDN Journal of Medicine. 2013;(S5):105-108
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The ante gravidity preparation of the patients who have an extrauterine pregnancy

Gott M.Y.


The comparative analysis of reproductive function of patients who have an extrauterine pregnancy and without one is given in this article.
RUDN Journal of Medicine. 2013;(S5):109-113
pages 109-113 views

The role of pregravid preparation in reproductive losses decrease at patients with a hyperprolactinaemia

Fadeeva N.I., Yavorskaya S.D.


Patients with infertility and hyperprolaktinaemia have early reproductive losses in 27,4% of cases after pregnancy in a natural cycle, in 33,7% of cases — after the assisted reproductive technologies (ART) programs. Programs of a pregravid preparation developed considering the individual risk factors, allows to reduce the frequency of reproductive losses to 5,8%, premature births — to 2,9%.
RUDN Journal of Medicine. 2013;(S5):114-119
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Underweight and gynecological disorders young women

Purshaeva E.S., Khamoshina M.B., Lebedeva M.G., Taraskina E.V., Dokuchaeva T.S., Orlova Y.S.


The results of kogornogo prospective study on the prevalence of underweight, frequency and structure of gynecological diseases in women 20—25 years old. Found that the prevalence of underweight in this cohort of 122,61‰, the prevalence of gynecological diseases — 489,83‰. They predominate inflammatory disease (47,9%), menstrual disorders (25,7%) and non-inflammatory disease of the cervix (20,3%). There is evidence that women with underweight incidence of gynecological diseases is 1,5 times higher compared to normovesnymi peers, low body weight in this cohort have a negative impact on the incidence of dysmenorrhea and menstrual disorders, as well as a risk factor for endometriosis. For women with underweight typical late menarche, slowing the formation of menstruation at puberty is reached reproductive age — the menstrual cycle on postponiruyuschemu type and high frequency of irregular and prolonged menstruation.
RUDN Journal of Medicine. 2013;(S5):120-129
pages 120-129 views

New ways to overcome infertility problem in women of advanced reproductive age

Ermolenko K.S., Gagaev C.G., Soloveva A.V., Rapoport S.I.


Assisted reproductive technologies (ART) efficacy directly depends on patient reproductive age. “Poor” ovary response, diminished quality of oocytes and embryos obtained and as a result decreased ability of blastocyst nidation to decidua are obstacles to good results of ART program. Melatonin, a neuropeptide, is well-known to be deeply involved in the process of organism ageing. This hormone takes part in oxidative stress degree decreasing in ovary follicles and defends oocytes from aggression of free radicals. The aim of this study was to assess the outcome of traditional ART program with additional correction with exogenic melatonin in infertile women of advanced reproductive age. It was characteristic for infertile patients of advanced reproductive age to have sharp decrease in levels of melatonin secretion. This reflects disturbances of hypothalamo-pituitary chain of reproductive system. Additional donation of exogenic melatonin (Melaxen) in some cases of ART program potentially increases the chances of successful outcome.
RUDN Journal of Medicine. 2013;(S5):130-136
pages 130-136 views

The peculiarities of treatment of cervical diseases associated with HPV-infections in teenag and young girls

Linask L.I., Grigorieva E.E., Kostyuchenko L.A.


The differential treatment has been worked up according to the form of ectopy and viral load and based on the study of colposcopic, cytologic and immunologic findings. The effectiveness of isolated immunomodulating therapy in case of uncomplicated cervical ectopy is 75,5%. The using of immunomodulators in complex therapy combined with radio coagulation allows to improve the effectiveness of treatment from 66% to 98,5% in the group of patients with complicated cervical ectopy if compared with the group where immunomodulators have not been taken.
RUDN Journal of Medicine. 2013;(S5):137-145
pages 137-145 views

Vaginal biotope in women of reproductive age with pelvic floor dysfunction

Totchiev G.F., Toktar L.R., Tigieva A.V., Zavadina E.V.


The article indicated the relevance of pelvic floor dysfunction in women of reproductive age. The dependence of the vaginal biotope and cervical disease from having NTD revealed the earliest pathognomonic sign of of pelvic floor dysfunction.
RUDN Journal of Medicine. 2013;(S5):146-150
pages 146-150 views

Quality of life of postmenopausal women with pelvic dysfunctions

Konnon R.D., Semyatov S.M., Khanzadyan M.L., Anagonou N.N., Alameddine A.K., Kodjo A.M.


Nowadays, it is clear that pelvic dysfunction is not associated with a significant risk to life. However, this issue has a significant impact on quality of life (QOL) of patients, leading to its degradation (physical, psychological, sexual, and family well-being). In our study we examined 274 postmenopausal women with pelvic dysfunctions, who were distributed in two groups: in I group included 145 patients (52,9%) who underwent surgical repair of pelvic dysfunction by traditional methods, II group contained 129 patients (47,1%) with the use of synthetic materials. Women were inquired by Quality of Life’s questionnaire «Short Form 36 Health Quality Survey» (SF-36) before and after surgical management. The results of the study showed that the quality of life in women after surgery improved better in group I than in group II.
RUDN Journal of Medicine. 2013;(S5):151-155
pages 151-155 views

Immunihistochemical analyses of collagen I and III and elastin in uteri ligaments in female genital prolapse

Khanzadyan M.L., Konnon R.D., Demura T.A.


The frequency of the female genital prolapse varies from 34,1% to 56,3% in different countries. Pathogenesis and morphological changes in uteri ligaments in female genital prolapse are not clear and have to be investigated. The goal of our study was to investigate uteri ligaments in female genital prolapse by immunohistochemical analyses of collagen I and III and elastin. The study was performed on biopsies of sacro-uterine and round ligaments from 15 women with genital prolapse and 15 women without prolapse. The tissues were fixed in formalin, embedded in paraffin and cut for the slide. Immunohistochemistry was done with primary antibodies collagen I and III (Novus Biologicus, 1:100 и 1:200 and elastin (Thermo Scientific, 1:100). Morphological analyses of ligaments in prolapse showed fibrosis and elastic fibers fragmentation. Immunohistochemical analyses revealed collagens disbalance: with prevalence of collagen III and decrease in elastin compared with control. Impairment in elastic fibers quantity and distribution affects microcirculation and results in connective tissue desorganisation in uterine ligaments, leading to genital prolapse. Further investigations are needed to reveal diagnostic markers and women at risk.
RUDN Journal of Medicine. 2013;(S5):156-163
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Diagnostic significance of additional instrumental methods of examination of patients with pelvic organ prolapse

Salimova L.Y., Shalaev O.N., Parsadanyan S.A., Omarova R.Z.


In this work the diagnostic importance and indications to application of various methods of research (ultrasonography of the pelvic organs and the pelvic floor, a complex urodynamic study, dynamic magnetic resonance imaging (MRI) orgnes of pelvis and pelvic floor) at patients with simple and complicated forms of pelvic organ prolapse is defined.
RUDN Journal of Medicine. 2013;(S5):164-169
pages 164-169 views

Modern concepts of management normal labor

Orazmuradov A.A., Paendi F.A., Golikova T.P., Startseva N.M., Lebedeva M.G.


This review presents data on some of the peculiarities of normal labor in modern conditions.
RUDN Journal of Medicine. 2013;(S5):170-176
pages 170-176 views

Premature birth. Diagnostics. Prevention

Hapova T.V., Olenev A.S., Shuravin V.M., Kuznetsova O.A., Smirnova T.V.


In the presented analysis of literature modern data of domestic and foreign researches, in the field of diagnostics and preventive action at premature birth are considered.
RUDN Journal of Medicine. 2013;(S5):177-183
pages 177-183 views

Peculiarities of application of hyperbaric oxygen of therapy in obstetrics

Orazmyradov A.A., Paendi O.L., Esipova L.N., Galina T.V., Ermolova N.P.


The survey provides data on the clinical effects of hyperbaric oxygen in obstetrics at various pregnancy complications and no illnesses related to pregnancy.
RUDN Journal of Medicine. 2013;(S5):184-190
pages 184-190 views

Compliance and its importance in pelvic organ prolapsed

Totchiev G.P., Toktar L.R., Muratchaeva D.M., Semiatov S.M.


The analysis of recent data on the prevalence and effectiveness of various treatments for pelvic organ prolapse in women justifies the need to study compliance surgical and “conservative” approach in the treatment of this disease .
RUDN Journal of Medicine. 2013;(S5):191-200
pages 191-200 views

Chronic pelvic inflammatory disease: controversial issues

Dukhin A.O., Luybeshkina V.A., Taraskina E.V.


Pelvic inflammatory disease (PID) is one of the most common serious infection of nonpregnant women of reproductive age. Goals of the therapy must include the resolution of clinical signs, the eradication of pathogens from genital tract and the prevention of sequelae primarily including the development of chronic inflammation. The paper deals with the currennt problems and contraversial issues of chronic pelvic inflammatory disease. This review presents the results of domestic and foreign studies, and the own view of the issue, the prospects and possible solutions.
RUDN Journal of Medicine. 2013;(S5):201-209
pages 201-209 views

Prospects for the use of an alternative approach to the treatment of etiopatogeneticheskogo of chronic nonspecific endometritis

Motovilova T.M., Kachalina T.S.


The article presents results of combined treatment of patients with chronic èndometritis, including intra-uterine polyvalent Bacteriophage introduction and procedure of the infrared laser. The analysis of direct and immediate results demonstrated viability and efficiency of the offered method of treatment as an alternative to traditional methods.
RUDN Journal of Medicine. 2013;(S5):210-218
pages 210-218 views

The endometrium in women receiving adjuvant tamoxifen therapy after surgical treatment of breast cance

Dmitrieva E.V., Pustotina O.A., Kostin I.N.


This article reviews the literature on the problem of optimizing the diagnosis of endometrial disease in women receiving adjuvant treatment with tamoxifen after surgery for breast cancer.
RUDN Journal of Medicine. 2013;(S5):219-224
pages 219-224 views

Molecular and genetic predictors of benign breast disease

Pavlova E.A., Ordiyants I.M., Plaksina N.D., Sokhova Z.M., Pogasov A.G.


This article presents the current data of world literature, highlighting the role of estrogen metabolites and regulation of this process in the pathogenesis of breast diseases.
RUDN Journal of Medicine. 2013;(S5):225-229
pages 225-229 views

Discussable questions regarding diagnosis of endometrium hyperplasia

Slusareva O.A.


Issues regarding diagnosis of endometrium hyperplasia (EH) are still under discussion. Despite of the variety of contradictory scientific investigations performed and an intensive search for EH and endometrium cancer molecular-genetic markers, it is still impossible to choose informative prognostic factors of the formation and development of the disease.
RUDN Journal of Medicine. 2013;(S5):230-234
pages 230-234 views

Management of pregnant women with chronic hepatitis B

Belopolskaya M.A.


Based on the literature and our research about effect of pregnancy on HBV, effect of HBV on the course of pregnancy and vertical transmission of HBV recommendations for treatment of pregnant women with HBV are given.
RUDN Journal of Medicine. 2013;(S5):235-240
pages 235-240 views

Study on characteristics of dentition among residents of Turkmenistan

Muradova M.S.


Study basic physiological functions of dentoalveolar system represents a significant theoretical and practical interest. At present, in the presence of extensive studies of the functions of dentoalveolar system conducted by physiologists, integrated approach to the study of age and Clinical Physiology this field is missing. The results of these studies are needed, as dentists and paediatricians, general practitioners and other clinicians.
RUDN Journal of Medicine. 2013;(S5):241-245
pages 241-245 views

Materials of dissertation research

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RUDN Journal of Medicine. 2013;(S5):246-253
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Our authors

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RUDN Journal of Medicine. 2013;(S5):254-262
pages 254-262 views

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