No 2 (2014)

The article presents data on changes in thermoregulation and heart rate variability due to local cooling of the hand from hot climate zone natives. Shown that a significant number of peripheral vascular spasms in response to local cooling do not occur, due to the peculiarities of thermoregulation.

In this paper according to the daily Holter monitoring data the analysis of possible mechanism of formation of nonparoxysmal atrial tachyarithmia is made for patients at night time.

This article describes the clinical and neurochemical correlations for eating disorders. These peculiarities must be considered in differential diagnosis and treatment of psychogenic vomiting and anorexia nervosa with bulimic episodes. Described disturbances of catecholamine excretion indicate reduction of adaptation mechanisms in conditions of prolonged food deprivation, which is a powerful psycho-emotional stress

The aim of the study was to evaluate relationship between patient characteristics and arterial stiffness assessed by carotid-femoral pulse wave velocity with plasma renin activity. 83 patients with untreated hypertension were examined. Patients with volume-mediated hypertension compared with patients with renin-mediated hypertension were older, had higher level of blood pressure and higher arterial stiffness.

Continuous ECG recordings were obtained using 24-hour Holter monitors (Shiller MT-200) in 60 healthy men (50 patients with nasal septum deviation (NSD) and in 10 men of control group) aged 25 to 39 years old. Patients with NSD had a septoplasty. They were divided into five groups. Group 1 consisted of patients without analgesia. Group 2, 3, 4 and 5 patients received metamizole sodium, diclofenac, ketorolac and ketamine respectively. Control group was marked as Group 0. The monitoring began 30 minutes before surgery and ended 24 hours after record beginning. Circadian index (CI) was calculated from both heart rate (HR) and ST segment (STS) data. Simple linear regression was performed between HR-derived and STS-derived CIs for each groups. Inter-groups Student's t-test was calculated. Obtained coefficients of determination varied from 0.60 to 0.87. STS- and HR-derived CIs were only statistically inequivalent in Group 1 (p < 0.05). Inter-groups analysis showed that 0 and 3 Groups were statistically equivalent and there was CI decrease in groups 4 and 5 (p<0.05). Tendency to decrease CI observed in Group 2. CI can be calculated not only heart rate, but also by the deviation of CST, which indicates the importance of CST not only as ischemia marker but also as an indicator of autonomic nervous system arousal.

Benign prostatic hyperplasia (BPH) is the most frequent disease among men of middle-aged, older, associated with increasing of lifetime of men and diagnosed in 42% to 87%. The purpose of our study is to improve the diagnosis of BPH without complications and with urine retention. Transrectal sonography was performed in 77 patients with BPH with assessment of blood flow by Doppler. The speed of blood flow measured in subcapsular and paraurethral arteries with estimation of diameter and speed of vein drain into the paraprostatic veins. Transrectal sonography showed the changes of the prostatic blood-flow especially in case of BPH with urine retention. Transrectal ultrsonography plays an important role in evaluation of the prostatic blood-flow.

The article deals with the problem of abortion in the Republic of Bashkortostan. Established reduction of abortion rate of 46.4% from 2003 to 2012, more significant in 2005-2007. Dynamics analysis showed decreasing of abortions in all age groups, except of 35-39 years old group. However, at the age of 15-17 years a positive trend was not so evident. Of all abortions in the Republic of Bashkortostan was 7.2% in primiparous, 92.9% were terminated before 12 weeks of pregnancy, increasing with the age. The rate of abortions of 12-21 weeks was the highest in the grope of 15-19 aged women, consequently 8.4%. During 2010-2012 years 30.0% of abortions were performed in the early terms of pregnancy and 16.6% of them - pharmacological. The proportion of women terminated pregnancy in the early terms was highest in group of 25-29 years (31.7%) and 30-34 years (32.6%) old women. The average age of women who terminated pregnancy was 28,76 ± 0,96 years.

A noninvasive method for diagnosis of chronic inflammatory periodontal diseases predicts a level of serious disorders of the oral local immunity, diagnose early changes in periodontal tissues, and timely perform preventive measures in young individuals living in the region with hazardous environment.

This article describes a technique of spiral CT, the results of which and through international response evaluation criteria conducted targeted therapy in treatment of patients with metastatic kidney cancer therapeutic tactics standardized reference this category of patients. As a result of diagnostic and therapeutic measures increases the efficiency of therapy and increases overall survival of patients with metastatic kidney cancer.

Treatment of hepatitis C is one of the most acute international healthcare problems. High standard in management of patients with HCV virus is combined therapy with pegylated interferon-a plus ribavirin. A necessity to develop new medications and to improve current treatment regiments is determined by high social and economic significance of this disease. Safety and tolerance assessment in healthy volunteers, definition of maximum tolerated dose are conducted in first phase clinical trial of original, Russian medication - pegylated interferon-a, named Algeron (INN - Cepeginterferon alfa-2b). Step by step dose escalation of Algeron in groups of several healthy volunteers was applied in this trial. Results of this trial demonstrated, that safety profile of Algeron has no significant differences with safety profiles of analogical pegylated interferon-a medications. Thus Algeron can be recommended for the second phase clinical trials.