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Role of sphingosine in inducted mechanisms of apoptosis of experimental acute renal tubular injury
- Authors: Belous YA1, Komarevtseva IA2, Komarevtsev VN3
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Affiliations:
- Peoples Friendship University of Russia
- Department of medical chemistry LGMU
- Department of surgery and urology LGMU
- Issue: No 3 (2008)
- Pages: 65-68
- Section: Articles
- URL: https://journals.rudn.ru/medicine/article/view/3657
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Abstract
Develop of apoptosis is a specific program. The sphingomielyne metabolites as ceramide and sphingosine, play an important role in programmed cell death.
It is known, that sphingosine is initiate as proliferation and apoptosis.
The purpose of this work is studies the roles of sphingosine in apoptosis activation due to acute renal tubular injury.
Our experimental data confirm supposition of existence sphingomielyne metabolitic way in activation of apoptosis. We are receive the date with contrary maintenance dynamics sphingomielyne and sphingosine in the kidney cells.
It is known, that sphingosine is initiate as proliferation and apoptosis.
The purpose of this work is studies the roles of sphingosine in apoptosis activation due to acute renal tubular injury.
Our experimental data confirm supposition of existence sphingomielyne metabolitic way in activation of apoptosis. We are receive the date with contrary maintenance dynamics sphingomielyne and sphingosine in the kidney cells.
About the authors
Y A Belous
Peoples Friendship University of RussiaКафедра психотерапии и наркологии ФПКМР; Российский университет дружбы народов; Peoples Friendship University of Russia
I A Komarevtseva
Department of medical chemistry LGMUDepartment of medical chemistry LGMU
V N Komarevtsev
Department of surgery and urology LGMUDepartment of surgery and urology LGMU
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