The biological factors influence alcoholic liver disease progression

P P Ogurtsov; Огурцов Павел Петрович; I V Garmash; Гармаш Ирина Владимировна; A E Guschin; Гущин Александр Евгеньевич; E V Tarasenko; Тарасенко Екатерина Владимировна; G I Myandina; Мяндина Галина Ивановна; O S Arisheva; Аришева Ольга Сергеевна; T S Polikarpova; Поликарпова Татьяна Сергеевна

The biological factors influence alcoholic liver disease progression

Authors: Ogurtsov PP¹, Garmash IV¹, Guschin AE², Tarasenko EV¹, Myandina GI¹, Arisheva OS¹, Polikarpova TS¹
Affiliations:
1. Peoples Friendship University of Russia
2. FBUN Epidemiology Research Institute
Issue: No 3 (2013)
Pages: 5-10
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/2699
Retraction date: 21.02.2018
Retraction reasons description:
The reason: duplicate publication (Journal of Scientific Articles Health and Education in the XXI Century. 2012. V. 14. No. 2. P. 140-141).

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Abstract

The aim of study was to detect the genetic factors which cause the predisposition for alcoholic liver damage. The main candidate genes of high risk are isoforms of adh and aldh genes which are responsible for different rate of alcohol metabolism and oxidation of ethanol and acetaldehyde. Our results demonstrated that allelic variant adh 2-2 is in a higher frequency in patients with alcoholic liver damage than in a population (16% vs. 7%; p < 0,05). The polymorphism t 174 m of angiotensinogen gene AGT was studied as risk factor of alcoholic liver damage. The allelic variant т of angiotensinogen gene AGT is more frequent (15,8%) in patients with alcoholic liver cirrhosis and alcohol abuse without cirrhosis (n = 98) than in a population (6,7%, n = 52; p = 0,04). the greater frequency of allele m was in a group with alcoholic liver cirrhosis (17,3%; p = 0,058). Our. data provides the evidence that polymorphism t 174 m of AGT gene does not influence the progression (clinical picture) of alcoholic liver cirrhosis, except the level of GGT, which is increased in patients with homozygous genotype tt.

Keywords

alcoholic liver cirrhosis, alcoholdehydrogenase, polymorphism adh2, polymorphism t174m, angiotensinogen gene AGT, the renin-angiotensin system

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Vol 28, No 4 (2024): ONCOLOGY

The biological factors influence alcoholic liver disease progression

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About the authors

P P Ogurtsov

I V Garmash

A E Guschin

E V Tarasenko

G I Myandina

O S Arisheva

T S Polikarpova

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