Indomethacin & SARS-CoV-2: Prospects for clinical management of the inflammatory state

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Abstract

Severe acute respiratory syndrome - (SARS) is a pandemic (called as SARS-CoV-2 or COVID-19), severely affected by transmission and fatal disease caused by unknown coronavirus family of RNA virus (SARS-COV). Humans are under great threat among other species were non-identified. Phenotype can range from asymptomatic to fulminate cytokine storm which leads multiorgan failure resulting death. Still the world is eagerly waiting for antiviral drug to stop the corona virus infection. Previous studies found that indomethacin had ability to inhibit the RNA and DNA virus replication. Objectives . Interleukins (IL), Interferons (IFN) and metabolites like «cyclopentane cyclooxygenase» (COX 1/COX 2) are active against several RNA viruses. Experts have divided the SARS infection in three phases (Phase-1, 2, 3) based on severity of infection. In phase-3 there was «cytokine storm» due to exuberant inflammation observed which can damage organs and even fatal. We investigated that effect of indomethacin on COX inhibitor on coronavirus replication and cytokine storm in reducing the hyper inflammatory state. In this article we tried to assess the clinical management of inflammation due to SARS-COV-2 by Indomethacin. Results . Indomethacin can cause relief from the pain on taking deep breath in corona virus infected patients. Indomethacin can be considered safe and effective for prevention and treatment of coronavirus infection also antiviral activity. Conclusion : Indomethacin is a potent inhibitor of SARS CoV-2.

About the authors

Satyanath R. Kodidala

K.D. Medical College, Hospital and Research Centre

Author for correspondence.
Email: ksatyanath1989@gmail.com
Mathura, India

J. Sorout

K.D. Medical College, Hospital and Research Centre

Email: ksatyanath1989@gmail.com
Mathura, India

S. Jayachandra

Zydus Medical College

Email: ksatyanath1989@gmail.com
Dahod, Gujarat, India

V. Narapogu

Government Medical College

Email: ksatyanath1989@gmail.com
Budaun, Uttar Pradesh, India

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Copyright (c) 2021 Kodidala S.R., Sorout J., Jayachandra S., Narapogu V.

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