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DEFENSINS-a AT AN EARLY AGE IN RATS WITH ACUTE SOMATIC PAIN
- Authors: Bykov I.M.1, Alekseev V.V.1
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Affiliations:
- The Kuban State Medical University
- Issue: Vol 23, No 1 (2019)
- Pages: 19-24
- Section: Physiology
- URL: https://journals.rudn.ru/medicine/article/view/21278
- DOI: https://doi.org/10.22363/2313-0245-2019-23-1-19-24
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Abstract
This article presents the results of studies on the reaction of α-defensins to acute somatic pain in newborn rats and in the early puberty period. Studies were carried out on white mongrel rats for three hours after pain exposure. The level of α-defensins was determined by enzyme immunoassay. During the experiments, a short-term increase in the level of α-defensins in newborns and rats in the early puberty period was revealed. At the same time, in animals of one month of age a two-phase, labile reaction of an increase in the level of α-defensins in peripheral blood occurs.
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About the authors
I. M. Bykov
The Kuban State Medical University
Author for correspondence.
Email: medj@rudn.university
SPIN-code: 9977-6613
Краснодар, Россия
V. V. Alekseev
The Kuban State Medical University
Email: medj@rudn.university
SPIN-code: 9982-7420
Ростов, Россия
References
- Wilson S.S., Wiens M.E., Smith J.G. Antiviral mechanisms of human defensins // J. Mol. Biol. 2013. № 425. P. 4965-4980.
- Hancock R.E., Haney E.F., and Gill E.E. (2016). The immunology of host defense peptides: beyond antimicrobial activity // Nat. Rev. Immunol. 2016. № 16. P. 321-334.
- Lehrer R., Lichtenstein A., Ganz T. Defensis: antimicrobial and cytotoxic peptides of mammalian cells // Annu. Rev. Immunol. 1993. Vol. 11. P. 105-128.
- Zeya H.I., Spitznagel J.K. Antibacterial and enzymatic basic protein from leukocyte lysosomes: separation and identification // Sience. 1963. Vol. 142. P. 1085-1087.
- Kokryakov V.N. Essays on innate immunity. SPb.: Science, 2006. 206 p.
- Lehrer R.I., Ganz T. Defensis of vertebrate animals // Curr. Opin. Immunol. 2006. Vol. 14. P. 96-102.
- Shilov Yu.I., Orlova E.G., Lanin D.V. Adrenergic mechanisms of regulation of the phagocytic activity of peripheral blood neutrophils under stress and the introduction of hydrocortisol // Immunopathology, Allergology, Infectology. 2004. Number 3. P. 8-13.
- Ovsyannikov V.G. Essays on the pathophysiology of pain. Rostov n/D.: Color printing, 2003. 159 p.
- Order of the Ministry of Health and Social Development of the Russian Federation No. 708n “On approval of laboratory practice rules” dated August 23, 2010. Rossiyskaya Gazeta, No. 240, 10/22/2010.
- Mikkel F., Kamp S., Cowland J.B., et al. Prodefensins are matrix proteins of human granules in human neutrophils // J. Leukoc. Biol. 2005. Vol. 8, No. 78. P. 785-793.
- Levi D. Adrenoreceptors, their stimulants and blockers // In the book: Endocrinology. Ed. N. Avalanche. Per. from English. M.: Practice, 1999. P. 54-60.
- Vorontsov I.M., Mazurin A.V. Propedeutics of childhood diseases. St. Petersburg, 2009. 1008 p.
