PECULIARITIES OF THE PHYSICO/BIOCHEMICAL PROPERTIES OF THE MOUTHLOID LIQUID IN CHILDREN WITH DENT CARICOS ON THE BACKGROUND OF PSYCHONEUVROLOGICAL DISORDERS

In children with psychoneurological disorders, the incidence of tooth decay is significantly higher in comparison with a healthy contingent. Oral fluid has a significant effect on the maintenance of homeostasis of the oral cavity and is a natural functional environment for the organs of the oral cavity. Some physicochemical parameters of the oral fluid are sensitive indicators of comorbid pathology, in par-ticular, neuropsychiatric disorders, and may have prognostic value for assessing the risk of caries develop-ment. The object of the study was children of different ages with psychoneurological disorders: mental retardation, autism, mental retardation, Down's syndrome, infantile cerebral palsy. As a control group, children with dental problems without psychoneurological disorders were examined. The aim of the study was to search for the relationship between the physico-biochemical properties of the oral fluid and the dental caries parameters in children with psychoneurological disorders. To achieve this goal, objective methods of examination with an index assessment of the state of hard tissues of the teeth, as well as deter-mination of the rate of salivation, concentration of chloride anions, and an integral assessment of the state of the antioxidant defense system in the oral cavity using a special coefficient of oxidative modification of biomolecules were used. The results of the study revealed higher rates of caries incidence against the back-ground of a decrease in the rate of oral fluid secretion and the level of chloride anions in comparison with the control group. A reliable inverse correlation between the coefficient of oxidative modification of biomolecules and the rate of secretion of oral fluid of medium severity in children with psychoneurological disorders of both age groups was also revealed, which indicates the effect of disturbance of oral fluid production on the development of local oxidative stress in children with psychoneurological disorders.