Аmino acids in serum and cerebrospinal fluid of children with Kanner syndrome

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  • Authors: Gorina AS1, Kolesnichenko LS2, Mikhnovich VI3
  • Affiliations:
    1. Sick Children Hospital Research Institute
    2. Irkutsk State Medical University
    3. Russian Research Institute for Health Family Problemsand Human Reproduction SB RAMS
  • Issue: No 3 (2012)
  • Pages: 76-82
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3618
  • Cite item

Abstract


Levels of amino acids in serum and cerebrospinal fluid (CSF) were measured in children with Kanner syndrome. Serum aspartate, taurine and glutamine were increased whereas β-alanine, methionine and glycine decreased. In CSF, aspartate, glutamine, GABA, taurine and arginine increased and methionine decreased. Majority of changes in serum were parallel to the changes in CSF, but the changes in serum were more pronounced than in CSF. Together with the deficit in methionine, β-alanine and glycine, obtained data suggest intensification of transportation of glutamine, aspartate and taurine into CSF through blood-brain barrier. Changes in the concentrations of neurotransmitter amino acids (aspartate, taurine) may indicate an imbalance of excitatory and inhibitory mediators in brain.

About the authors

A S Gorina

Sick Children Hospital Research Institute

Email: annagor98@mail.ru
Sick Children Hospital Research Institute

L S Kolesnichenko

Irkutsk State Medical University

Email: kolesnichenkols@mail.ru <mailto:kolesnichenkols@mail.ru>
Кафедра химии и биохимии; Иркутский государственный медицинский университет; Irkutsk State Medical University

V I Mikhnovich

Russian Research Institute for Health Family Problemsand Human Reproduction SB RAMS

Russian Research Institute for Health Family Problemsand Human Reproduction SB RAMS

References

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Copyright (c) 2012 Горина А.С., Колесниченко Л.С., Михнович В.И.

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