The influence of chemical polyamines analogs, decarboxylated ornithine and s-(adenosyl)-methionine on the polyamine synthsis velocity in test-systems from tissues with high proliferation

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Abstract


The aliphatic (amino)- and (oxy)-derivatives of polyamines effect on the rate of polyamines (Putrescine, Spermidine and Spermine) synthesis in cell-free test-systems from rat's regenerating liver and Hepatoma tissues was examined. The common known inhibitors of polyamines synthesis were also used for the analysis. The research data confirm that cell-free model systems function adequately to applied tests. The effectiveness of anti-proliferate action of chemical compounds was valued by the inhibition degree of Putrescine and polyamines synthesis. In addition, the coefficient of ratio Spermidine (moles)/ Spermine (moles) and the value of total Polyamines pool after 1 h of test-systems incubation with chemical compound were calculated. From the tested compounds 1-aminooxy-3-aminopropan (I), S-(5'-desoxyadenosile)-S-methyl-β-thioethyl-hydroxylamine (IV) and ethylenediamine (V) did satisfied the requirements to a considerable degree.

S P Siatkin

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

Т Т Berezov

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

T V Fedoronchuk

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

N Yа Gridina

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

E A Neborakh

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

N A Shevkhun

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

N A Sokueva

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

E V Ustinova

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

R I Sokuev

Russian Peoples' Friendship University

Email: syata@mail.ru
Russian Peoples' Friendship University

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Copyright (c) 2010 Сяткин С.П., Березов Т.Т., Федорончук Т.В., Гридина Н.Я., Неборак Е.А., Шевкун Н.А., Сокуева Н.А., Устинова Е.В., Сокуев Р.И.

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