The blockade of the reinforcing effects of angiotensin-II on hemodynamic parameters in rats with experimental diabetes mellitus

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  • Authors: Serova ON1, Kalashnikova EY.2, Elfimov AI2, Lagutina LV1, Torshin VI2
  • Affiliations:
    1. Research institute of normal physiology n.a. P.K. Anokhin
    2. Peoples’ Friendship University of Russia
  • Issue: No 3 (2015)
  • Pages: 9-13
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3148
  • Cite item

Abstract


Diabetes mellitus (DM) causes not only carbohydrate metabolism, but and disorders of the cardiovascular system, resulting in developing hypertension. It is known that in the regulation of hemodynamics the renin-angiotensin system plays an important role, the effector peptide of which is angiotensin II (A-II) causes hypertension and increases the heart rate (HR). In this work we studied the change in systolic blood pressure (SBP) and HR under the action of A-II in rats with experimental autoimmune type 1 DM. Autoimmune diabetes in Wistar rats was induced by injections of streptozotocin. Two weeks after the third injection, SBP and HR were measured in animals. The day before the start of the experiment the blood glucose level was detected. The results showed the absence of hypertensive properties of A-II and its reinforcing effect on HR in rats with autoimmune diabetes, indicating diabetic hyperglycemia as the main factor in the ineffectiveness of the action of A-II on hemodynamic parameters. It can be assumed that the significant increase of blood glucose level in condition of autoimmune diabetes type 1 DM occurs specific desensitization of receptors to A-II in the central and peripheral structures governing the SPB and HR, i.e., the blockade of the physiological action of this peptide.

About the authors

O N Serova

Research institute of normal physiology n.a. P.K. Anokhin

Email: lab_motiv@mail.ru
Laboratory of physiology of motivations

E Yu Kalashnikova

Peoples’ Friendship University of Russia

Email: ekalashnikovarm1986@mail.ru
Department of normal physiology Medical Institute

A I Elfimov

Peoples’ Friendship University of Russia

Email: ae39@mail.ru
Department of normal physiology Medical Institute

L V Lagutina

Research institute of normal physiology n.a. P.K. Anokhin

Email: l.lagutina@nphys.ru
Laboratory of physiology of motivations

V I Torshin

Peoples’ Friendship University of Russia

Email: vtorshin@mail.ru
Department of normal physiology Medical Institute

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Copyright (c) 2015 Серова О.Н., Калашникова Е.Ю., Елфимов А.И., Лагутина Л.В., Торшин В.И.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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