Meningococcal vaccine. From capsular polysaccharides of microbes to proteases
- Authors:
Alliluyev AP1, Anokhina IV1, Rumsh LD2, Melnikov EE2, Kotelnikova OV2, Sitnikova EA2, Drozzina EJ2, Zhigis LS2, Yagudayeva EJ2, Razgulyaeva OA2, Zueva VS2, Kozlov LV3, Avakov AE4
-
Affiliations:
- People’s Friendship University
- Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
- ederal budgetary institution of science Moscow Research Institute of Epidemiology and Microbiology n. a. G.N. Gabrichevskiy
- Ltd. “Bio-Diagnostics”
- Issue: No 4 (2012)
- Pages: 16-22
- Section:
Articles
- URL: https://journals.rudn.ru/medicine/article/view/3627
Cite item
Abstract
Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever. Their application in the form of conjugates with protein carriers eliminate the gap in protection against these infections in children under one year. Extremely promising turned out offered us a new generation of vaccines, which have synthetic peptides conjugated to a meningococcal polysaccharide. Thus, new approaches to the solution of the problem of meningococcal disease vaccination serogroup B were open. In recent years, Russian researchers first suggested to use IgA1 protease (one of the major virulence factors of microbes and almost identical for mentioned below infections) for prevention of such diseases as meningococcal of all serogroups, pneumococcus and hemophilia infections. Patented processes for producing of the vaccine define domestic priority of its production and use.
About the authors
People’s Friendship University
Email: rudnvestnik@yandex.ru
Faculty of Medicine
People’s Friendship University
Email: rudnvestnik@yandex.ru
Faculty of Medicine
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
ederal budgetary institution of science Moscow Research Institute of Epidemiology and Microbiology n. a. G.N. Gabrichevskiy
Ltd. “Bio-Diagnostics”
Copyright (c) 2012 Аллилуев А.П., Анохина И.В., Румш Л.Д., Мельников Э.Э., Котельникова О.В., Ситникова Е.А., Дрожжина Е.Ю., Жигис Л.С., Ягудаева Е.Ю., Разгуляева О.А., Зуева В.С., Козлов Л.В., Аваков А.Э.
This work is licensed under a
Creative Commons Attribution 4.0 International License.
Email this article 
