Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

N V Dozmorova; Дозморова Н В; V L Gein; Гейн В Л; N N Kasimova; Касимова Н Н; L I Varkentin; Варкентин Л И; B Ya Syropyatov; Сыропятов Б Я; N V Danilova; Данилова Н В

Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

Authors: Dozmorova NV¹, Gein VL¹, Kasimova NN¹, Varkentin LI¹, Syropyatov BY.¹, Danilova NV¹
Affiliations:
1. Perm state pharmaceutical academy
Issue: No 4 (2009)
Pages: 378-380
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/2514

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Abstract

Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,4-diaryl-1,4,5,6-tetrahydro-6-oxo-5-(2-(3-indolil)-ethyl)pyrrolo[3,4-c]pyrazoles (II) by reaction with hydrazine-hydrate. The structure of received compounds is established. The analgetical activity of compounds (I б-е) and (II) is investigated.