Diagnostics of the hepatic fibrosis and cirrhosis in children by means of serum markers

A N Surkov; Сурков А Н; A S Potapov; Потапов А С; I E Smirnov; Смирнов И Е; A G Kucherenko; Кучеренко А Г; T S Chetkina; Четкина Т С; O F Tatyanina; Татьянина О Ф

Diagnostics of the hepatic fibrosis and cirrhosis in children by means of serum markers

Authors: Surkov AN¹, Potapov AS¹, Smirnov IE¹, Kucherenko AG¹, Chetkina TS¹, Tatyanina OF¹
Affiliations:
1. Scientific Center of Children's Health
Issue: No 4 (2009)
Pages: 158-162
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/2453

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Abstract

Possibilities of application of hyaluronic acid and type IV collagen levels in serum for noninvasive diagnostics of various stages of hepatic fibrosis in children with chronic liver diseases are studied. It is established that serum concentration of these biochemical markers significantly change at the expressed sclerotic processes in hepatic tissue. Hyaluronic acid and type IV collagen are reliable noninvasive markers of severe fibrosis and cirrhosis of liver, can be used in pediatric practice for specification of a stage of process in hepatic parenchyma at impossibility of carrying out liver biopsy, and also for an estimation of dynamics of fibrosis and monitoring of efficiency of therapy at chronic liver diseases.

Keywords

hyaluronic acid, type IV collagen, hepatic cirrhosis, diagnostic, children

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Vol 28, No 4 (2024): ONCOLOGY

Diagnostics of the hepatic fibrosis and cirrhosis in children by means of serum markers

Full Text

Abstract

Keywords

About the authors

A N Surkov

A S Potapov

I E Smirnov

A G Kucherenko

T S Chetkina

O F Tatyanina

References

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