Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis

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  • Authors: Kublinsky KS1, Evtushenko ID1, Naslednikova IO1, Agarkova TA2
  • Affiliations:
    1. Medical Research Associate, clinical gynaecologist at Siberian State Medical University
    2. State Scientific Research Institution of Obstetrics, Gynaecology and Perinatology
  • Issue: No S6 (2012)
  • Pages: 102-109
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3678
  • Cite item

Abstract


92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives). The effect of the therapy increases as increases the possibility of pregnancy in the presence of IL2 gene T-330G TT polymorphism variant and IL4 gene C-590T CC polymorphism variant in the genotype of a woman. The decreased effect of infertility treatment with the diagnosed endometriosis is associated with the presence of the hazardous genotype combination: IL2 gene T-330G GG polymorphism and IL4 gene C-590T TT polymorphism.

About the authors

K S Kublinsky

Medical Research Associate, clinical gynaecologist at Siberian State Medical University

Email: kublinskiy@sibmail.com
Federal Institution of Higher Professional Education controlled by Ministry of Health and Social Development of Russian Federation

I D Evtushenko

Medical Research Associate, clinical gynaecologist at Siberian State Medical University

Email: evtushenko_id@mail.ru
Federal Institution of Higher Professional Education controlled by Ministry of Health and Social Development of Russian Federation

I O Naslednikova

Medical Research Associate, clinical gynaecologist at Siberian State Medical University

Email: ira_naslednikova@mail.ru
Federal Institution of Higher Professional Education controlled by Ministry of Health and Social Development of Russian Federation

T A Agarkova

State Scientific Research Institution of Obstetrics, Gynaecology and Perinatology

Email: agarkina@mail.ru
Tomsk Scientific Centre, Siberian Department of Russian Academy of Medical Science

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Copyright (c) 2012 Кублинский К.С., Евтушенко И.Д., Наследникова И.О., Агаркова Т.А.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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