Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis

K S Kublinsky; Кублинский К С; I D Evtushenko; Евтушенко И Д; I O Naslednikova; Наследникова И О; T A Agarkova; Агаркова Т А

Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis

Authors: Kublinsky KS¹, Evtushenko ID¹, Naslednikova IO¹, Agarkova TA²
Affiliations:
1. Medical Research Associate, clinical gynaecologist at Siberian State Medical University
2. State Scientific Research Institution of Obstetrics, Gynaecology and Perinatology
Issue: No S6 (2012)
Pages: 102-109
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3678

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Abstract

92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives). The effect of the therapy increases as increases the possibility of pregnancy in the presence of IL2 gene T-330G TT polymorphism variant and IL4 gene C-590T CC polymorphism variant in the genotype of a woman. The decreased effect of infertility treatment with the diagnosed endometriosis is associated with the presence of the hazardous genotype combination: IL2 gene T-330G GG polymorphism and IL4 gene C-590T TT polymorphism.

Keywords

endometriosis, infertility, interleukin-2, interleukin-4, cytokines genes polymorphism

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Vol 29, No 1 (2025)

Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis

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Abstract

Keywords

About the authors

K S Kublinsky

I D Evtushenko

I O Naslednikova

T A Agarkova

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